6DFY
| Remodeled crystal structure of DNA-bound DUX4-HD2 | Descriptor: | DNA (5'-D(*AP*AP*GP*AP*TP*TP*AP*GP*AP*TP*TP*AP*GP*T)-3'), DNA (5'-D(*TP*TP*CP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*A)-3'), Double homeobox protein 4 | Authors: | Aihara, H, Shi, K. | Deposit date: | 2018-05-15 | Release date: | 2018-09-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.623 Å) | Cite: | Comment on structural basis of DUX4/IGH-driven transactivation. Leukemia, 32, 2018
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6N57
| Cryo-EM structure of Escherichia coli RNAP polymerase bound with TraR in conformation I | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | Deposit date: | 2018-11-21 | Release date: | 2020-02-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
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8EBK
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8I54
| Lb2Cas12a RNA DNA complex | Descriptor: | DNA (25-MER), DNA (5'-D(*AP*GP*TP*GP*CP*TP*TP*TP*A)-3'), Lb2Cas12a, ... | Authors: | Li, J, Sivaraman, J, Satoru, M. | Deposit date: | 2023-01-24 | Release date: | 2023-02-22 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage. Plos Biol., 21, 2023
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7LS3
| Co-complex CYP46A1 with 8114 (3f) | Descriptor: | (5-methyl-2-pyridin-4-yl-phenyl)-[4-oxidanyl-4-(phenylmethyl)piperidin-1-yl]methanone, Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Lane, W, Yano, J. | Deposit date: | 2021-02-17 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H). J.Med.Chem., 64, 2021
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6VNW
| Cryo-EM structure of apo-BBSome | Descriptor: | BBS1 domain-containing protein, Bardet-Biedl syndrome 18 protein, Bardet-Biedl syndrome 2 protein homolog, ... | Authors: | Yang, S, Walz, T, Nachury, M, Chou, H. | Deposit date: | 2020-01-29 | Release date: | 2020-07-01 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes. Elife, 9, 2020
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6MH8
| High-viscosity injector-based Pink Beam Serial Crystallography of Micro-crystals at a Synchrotron Radiation Source | Descriptor: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a, Soluble cytochrome b562 chimeric construct | Authors: | Martin-Garcia, J.M, Zhu, L, Mendez, D, Lee, M, Chun, E, Li, C, Hu, H, Subramanian, G, Kissick, D, Ogata, C, Henning, R, Ishchenko, A, Dobson, Z, Zhan, S, Weierstall, U, Spence, J.C.H, Fromme, P, Zatsepin, N.A, Fischetti, R.F, Cherezov, V, Liu, W. | Deposit date: | 2018-09-17 | Release date: | 2019-04-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source. Iucrj, 6, 2019
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8DVV
| Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions | Descriptor: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | Authors: | Iyer, K.A, Hu, Y, Murayama, T, Samso, M. | Deposit date: | 2022-07-29 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions To Be Published
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8IAI
| Structure of mammalian spectrin-actin junctional complex of membrane skeleton, State II, Global map | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Li, N, Chen, S, Gao, N. | Deposit date: | 2023-02-08 | Release date: | 2023-05-03 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of membrane skeleton organization in red blood cells. Cell, 186, 2023
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7LRL
| Co-complex CYP46A1 with 7742 (Soticlestat/TAK-935)) | Descriptor: | Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, [4-oxidanyl-4-(phenylmethyl)piperidin-1-yl]-(2-pyridin-4-ylpyridin-3-yl)methanone | Authors: | Lane, W, Yano, J. | Deposit date: | 2021-02-16 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.995 Å) | Cite: | Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H). J.Med.Chem., 64, 2021
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8DTY
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7LS4
| Co-complex CYP46A1 with 9129 (1b) | Descriptor: | Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, [5,5-dimethyl-3-(2-methylphenyl)-4~{H}-pyrazol-1-yl]-pyridin-4-yl-methanone | Authors: | Lane, W, Yano, J. | Deposit date: | 2021-02-17 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H). J.Med.Chem., 64, 2021
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8DTZ
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8IGR
| Cryo-EM structure of CII-dependent transcription activation complex | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. | Deposit date: | 2023-02-21 | Release date: | 2023-05-17 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
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8IGS
| Cryo-EM structure of RNAP-promoter open complex at lambda promoter PRE | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. | Deposit date: | 2023-02-21 | Release date: | 2023-05-17 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
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7D8O
| Crystal structure of E. coli ToxIN type III toxin-antitoxin complex | Descriptor: | Antitoxin RNA, Type III toxin-antitoxin system ToxN/AbiQ family toxin | Authors: | Manikandan, P, Rothweiler, U, Singh, M. | Deposit date: | 2020-10-08 | Release date: | 2022-01-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.097 Å) | Cite: | Identification, functional characterization, assembly and structure of ToxIN type III toxin-antitoxin complex from E. coli. Nucleic Acids Res., 50, 2022
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8I02
| Cryo-EM structure of the SIN3S complex from S. pombe | Descriptor: | Chromatin modification-related protein eaf3, Cph1, Histone deacetylase clr6, ... | Authors: | Wang, C, Guo, Z, Zhan, X. | Deposit date: | 2023-01-10 | Release date: | 2023-05-03 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Two assembly modes for SIN3 histone deacetylase complexes. Cell Discov, 9, 2023
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8HSR
| Thermus thermophilus Rho-engaged RNAP elongation complex (composite structure) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (31-MER), ... | Authors: | Murayama, Y, Ehara, H, Sekine, S. | Deposit date: | 2022-12-20 | Release date: | 2023-05-03 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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8I03
| Cryo-EM structure of the SIN3L complex from S. pombe | Descriptor: | Chromatin modification-related protein png2, Histone deacetylase clr6, POTASSIUM ION, ... | Authors: | Wang, C, Guo, Z, Zhan, X. | Deposit date: | 2023-01-10 | Release date: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Two assembly modes for SIN3 histone deacetylase complexes. Cell Discov, 9, 2023
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7DBH
| The mouse nucleosome structure containing H3mm18 | Descriptor: | DNA (126-MER), Histone H2A type 1-B, Histone H2B type 3-A, ... | Authors: | Hirai, S, Takizawa, Y, Kujirai, T, Kurumizaka, H. | Deposit date: | 2020-10-20 | Release date: | 2022-01-19 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant. Nucleic Acids Res., 50, 2022
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2HQK
| Crystal structure of a monomeric cyan fluorescent protein derived from Clavularia | Descriptor: | ACETATE ION, CHLORIDE ION, Cyan fluorescent chromoprotein, ... | Authors: | Henderson, J.N, Campbell, R.E, Ai, H, Remington, S.J. | Deposit date: | 2006-07-18 | Release date: | 2007-01-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Directed evolution of a monomeric, bright and photostable version of Clavularia cyan fluorescent protein: structural characterization and applications in fluorescence imaging. Biochem.J., 400, 2006
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8C2S
| Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J. | Deposit date: | 2022-12-22 | Release date: | 2023-12-20 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. Embo J., 43, 2024
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6VOJ
| Chloroplast ATP synthase (R3, CF1FO) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase delta chain, ... | Authors: | Yang, J.-H, Williams, D, Kandiah, E, Fromme, P, Chiu, P.-L. | Deposit date: | 2020-01-30 | Release date: | 2020-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.34 Å) | Cite: | Structural basis of redox modulation on chloroplast ATP synthase. Commun Biol, 3, 2020
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2HWL
| Crystal structure of thrombin in complex with fibrinogen gamma' peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen gamma' peptide, Prothrombin, ... | Authors: | Pineda, A.O, Chen, Z.W, Marino, F, Mathews, F.S, Mosesson, M.W, Di Cera, E. | Deposit date: | 2006-08-01 | Release date: | 2006-09-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of thrombin in complex with fibrinogen gamma' peptide. Biophys.Chem., 125, 2007
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6N06
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