2PRL
 
 | | The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site | | Descriptor: | 5-METHOXY-2-[(4-PHENOXYPHENYL)AMINO]BENZOIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... | | Authors: | Walse, B, Dufe, V.T, Al-Karadaghi, S. | | Deposit date: | 2007-05-04 | | Release date: | 2008-05-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites
Biochemistry, 47, 2008
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8HYJ
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1X1Z
 | | Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump) | | Descriptor: | 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase | | Authors: | Fujihashi, M, Bello, A.M, Poduch, E, Wei, L, Annedi, S.C, Pai, E.F, Kotra, L.P. | | Deposit date: | 2005-04-15 | | Release date: | 2005-12-06 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | An unprecedented twist to ODCase catalytic activity
J.Am.Chem.Soc., 127, 2005
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1XGE
 | | Dihydroorotase from Escherichia coli: Loop Movement and Cooperativity between subunits | | Descriptor: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Dihydroorotase, N-CARBAMOYL-L-ASPARTATE, ... | | Authors: | Lee, M, Chan, C.W, Guss, J.M, Christopherson, R.I, Maher, M.J. | | Deposit date: | 2004-09-17 | | Release date: | 2005-04-26 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Dihydroorotase from Escherichia coli: Loop Movement and Cooperativity between Subunits
J.Mol.Biol., 348, 2005
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1VQT
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1XJW
 | | The Structure of E. coli Aspartate Transcarbamoylase Q137A Mutant in The R-State | | Descriptor: | Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ... | | Authors: | Stieglitz, K.A, Alam, N, Xia, J, Gourinath, S, Tsuruta, H, Kantrowitz, E.R. | | Deposit date: | 2004-09-25 | | Release date: | 2005-05-24 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | A Single Amino Acid Substitution in the Active Site of Escherichia coli Aspartate Transcarbamoylase Prevents the Allosteric Transition.
J.Mol.Biol., 349, 2005
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1YIS
 | | Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase | | Descriptor: | SULFATE ION, adenylosuccinate lyase | | Authors: | Symersky, J, Schormann, N, Lu, S, Zhang, Y, Karpova, E, Qiu, S, Huang, W, Cao, Z, Zhou, J, Luo, M, Arabshahi, A, McKinstry, A, Luan, C.-H, Luo, D, Johnson, D, An, J, Tsao, J, Delucas, L, Shang, Q, Gray, R, Li, S, Bray, T, Chen, Y.-J, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2005-01-12 | | Release date: | 2005-01-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase
To be Published
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1LOR
 | | crystal structure of orotidine 5'-monophosphate complexed with BMP | | Descriptor: | 6-HYDROXYURIDINE-5'-PHOSPHATE, orotidine monophosphate decarboxylase | | Authors: | Wu, N, Pai, E.F. | | Deposit date: | 2002-05-06 | | Release date: | 2002-08-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylase.
J.Biol.Chem., 277, 2002
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1ML4
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6YB8
 | | Human octameric PAICS in complex with CAIR and SAICAR | | Descriptor: | (2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car bonylamino]butanedioic acid, 1,2-ETHANEDIOL, 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, ... | | Authors: | Skerlova, J, Unterlass, J, Gottmann, M, Homan, E, Helleday, T, Jemth, A.S, Stenmark, P. | | Deposit date: | 2020-03-16 | | Release date: | 2020-07-08 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
J.Biol.Chem., 295, 2020
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1LOS
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1LOQ
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1NBE
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1ORO
 | | A FLEXIBLE LOOP AT THE DIMER INTERFACE IS A PART OF THE ACTIVE SITE OF THE ADJACENT MONOMER OF ESCHERICHIA COLI OROTATE PHOSPHORIBOSYLTRANSFERASE | | Descriptor: | OROTATE PHOSPHORIBOSYLTRANSFERASE, SULFATE ION | | Authors: | Henriksen, A, Aghajari, N, Jensen, K.F, Gajhede, M. | | Deposit date: | 1995-09-11 | | Release date: | 1996-04-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase.
Biochemistry, 35, 1996
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1OVD
 | | THE K136E MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A IN COMPLEX WITH OROTATE | | Descriptor: | DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | | Authors: | Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. | | Deposit date: | 2003-03-26 | | Release date: | 2003-08-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function.
J.Biol.Chem., 278, 2003
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7ZEA
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1ZA2
 | | Structure of wild-type E. coli Aspartate Transcarbamoylase in the presence of CTP, carbamoyl phosphate at 2.50 A resolution | | Descriptor: | Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Wang, J, Stieglitz, K.A, Cardia, J.P, Kantrowitz, E.R. | | Deposit date: | 2005-04-05 | | Release date: | 2005-06-07 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for ordered substrate binding and cooperativity in aspartate transcarbamoylase
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2AQW
 | | Structure of putative orotidine-monophosphate-decarboxylase from Plasmodium yoelii (PY01515) | | Descriptor: | IODIDE ION, SULFATE ION, putative orotidine-monophosphate-decarboxylase | | Authors: | Dong, A, Vedadi, M, Wasney, G, Zhao, Y, Lew, J, Alam, Z, Melone, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | | Deposit date: | 2005-08-18 | | Release date: | 2005-08-30 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
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1A9X
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2BSL
 | | Crystal structure of L. lactis dihydroorotate dehydrogense A in complex with 3,4-dihydroxybenzoate | | Descriptor: | 3,4-DIHYDROXYBENZOIC ACID, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE A, ... | | Authors: | Wolfe, A.E, Hansen, M, Gattis, S.G, Hu, Y.-C, Johansson, E, Arent, S, Larsen, S, Palfey, B.A. | | Deposit date: | 2005-05-23 | | Release date: | 2006-08-29 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis.
Biochemistry, 46, 2007
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2BTU
 | | Crystal structure of Phosphoribosylformylglycinamidine cyclo-ligase from Bacillus Anthracis at 2.3A resolution. | | Descriptor: | PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE | | Authors: | Moroz, O.V, Blagova, E.V, Levdikov, V.M, Fogg, M.J, Lebedev, A.A, Brannigan, J.A, Wilkinson, A.J, Wilson, K.S. | | Deposit date: | 2005-06-07 | | Release date: | 2006-08-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Crystal Structure of Phosphoribosylformylglycinamidine Cyclo-Ligase from Bacillus Anthracis at 2.3A Resolution.
To be Published
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2BX7
 | | Crystal structure of L. lactis dihydroorotate dehydrogense A in complex with 3,5-dihydroxybenzoate | | Descriptor: | 3,5-DIHYDROXYBENZOATE, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ... | | Authors: | Wolfe, A.E, Hansen, M, Gattis, S.G, Hu, Y.-C, Johansson, E, Arent, S, Larsen, S, Palfey, B.A. | | Deposit date: | 2005-07-25 | | Release date: | 2006-08-29 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis.
Biochemistry, 46, 2007
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2AT1
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2CZE
 | | Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with UMP | | Descriptor: | CITRIC ACID, GLYCEROL, Orotidine 5'-phosphate decarboxylase, ... | | Authors: | Arai, R, Ito, K, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-07-13 | | Release date: | 2006-01-13 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with UMP
To be Published
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2CZD
 | | Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 at 1.6 A resolution | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, Orotidine 5'-phosphate decarboxylase | | Authors: | Arai, R, Ito, K, Kamo-Uchikubo, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-07-13 | | Release date: | 2006-01-13 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 at 1.6 A resolution
To be Published
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