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4P7S	Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine Descriptor: 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine, Macrophage migration inhibitory factor-like protein Authors: Pantouris, G, Lolis, E. Deposit date: 2014-03-27 Release date: 2014-10-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.87 Å) Cite: Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors. J.Med.Chem., 57, 2014
4PKZ	Crystal structure of P1M mutant of Macrophage Migration Inhibitory Factor Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2014-05-15 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4PLU	Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-05-19 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4PKK	Crystal structure of Macrophage Migration inhibitory factor in complex with furan-2-ylmethyl)imino methanethiol Descriptor: (Z)-[(furan-2-ylmethyl)imino]methanethiol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-05-14 Release date: 2016-05-04 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Crystal structure of Macrophage Migration inhibitory factor with a covalent inhibitor To Be Published
4Q3F	Human D-DT complexed with tartrate Descriptor: D-dopachrome decarboxylase, L(+)-TARTARIC ACID Authors: Rajasekaran, D, Lolis, E. Deposit date: 2014-04-11 Release date: 2014-06-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. Faseb J., 28, 2014
3HOF	Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution Descriptor: CAFFEIC ACID, Macrophage migration inhibitory factor Authors: Crawley, L, Barker, J, Cheng, R.K.Y, Wood, M, Felicetti, B. Deposit date: 2009-06-02 Release date: 2009-06-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution To be Published
3IJJ	Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer) Descriptor: (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid, (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ... Authors: Crichlow, G.V, Cho, Y, Lolis, E.J. Deposit date: 2009-08-04 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107, 2010
3IJG	Macrophage Migration Inhibitory Factor (MIF) Bound to the (R)-Stereoisomer of AV1013 Descriptor: (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, CHLORIDE ION, Macrophage migration inhibitory factor Authors: Crichlow, G.V, Cho, Y, Lolis, E.J. Deposit date: 2009-08-04 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107, 2010
3KAN	D-dopachrome tautomerase (D-DT)/macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP Descriptor: 4-phenylpyrimidine, CHLORIDE ION, D-dopachrome tautomerase Authors: Zierow, S, Lolis, E. Deposit date: 2009-10-19 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. Faseb J., 28, 2014
3JSF	Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution Descriptor: 7-(2-fluorobenzyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION Authors: Mclean, L, Zhang, Y. Deposit date: 2009-09-10 Release date: 2009-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009
3JSG	Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution Descriptor: 7-(pyridin-3-ylmethyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION Authors: Mclean, L, Zhang, Y. Deposit date: 2009-09-10 Release date: 2009-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009
3JTU	Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 708 at 1.86a resolution Descriptor: 7-(pyridin-2-ylmethyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION Authors: Mclean, L, Zhang, Y. Deposit date: 2009-09-14 Release date: 2009-11-10 Last modified: 2017-11-01 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009
3KER	D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP Descriptor: 4-phenylpyrimidine, CHLORIDE ION, D-dopachrome decarboxylase, ... Authors: Zierow, S, Lolis, E. Deposit date: 2009-10-26 Release date: 2010-10-13 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.78 Å) Cite: Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. Faseb J., 28, 2014
3L5T	Crystal structure of macrophage migration inhibitory factor (MIF) with thiophenepiperazinylquinolinone inhibitor at 1.86A resolution Descriptor: 1-methyl-2-oxo-4-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,2-dihydroquinoline-3-carbonitrile, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3L5R	Crystal structure of macrophage migration inhibitory factor (MIF) with phenylchromenone inhibitor at 1.94A resolution Descriptor: 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3L5U	Crystal structure of macrophage migration inhibitory factor (MIF) with benzothiazole inhibitor at 1.90A resolution Descriptor: 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3L5S	Crystal structure of macrophage migration inhibitory factor (MIF) with imidazopyrimidinylphenyl inhibitor at 1.86A resolution Descriptor: 5-ethyl-2-(phenylcarbonyl)imidazo[1,2-a]pyrimidin-7(1H)-one, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3L5V	Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3L5P	Crystal structure of macrophage migration inhibitory factor (MIF) with imidazopyridazinol inhibitor at 1.80A resolution Descriptor: 2-(1-methylethyl)imidazo[1,2-b]pyridazin-6-ol, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
9B0M	Crystal structure of Macrophage migration inhibitory factor from Plasmodium vivax Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, L-dopachrome isomerase Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2024-03-12 Release date: 2024-03-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of Macrophage migration inhibitory factor from Plasmodium vivax To be published
8UR4	Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (I4122 form) Descriptor: CHLORIDE ION, MACROPHAGE MIGRATION INHIBITORY FACTOR Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-10-25 Release date: 2024-03-20 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (I4122 form) To be published
8VFK	Crystal Structure of Delta 109-117 D-Dopachrome Tautomerase (D-DT) Descriptor: CITRATE ANION, D-dopachrome decarboxylase, SODIUM ION Authors: Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. Deposit date: 2023-12-21 Release date: 2024-05-01 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.59 Å) Cite: The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
8VDY	Crystal Structure of Delta 114-117 D-Dopachrome Tautomerase (D-DT) Descriptor: D-dopachrome decarboxylase Authors: Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. Deposit date: 2023-12-18 Release date: 2024-05-01 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.44 Å) Cite: The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
8VG7	Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT) Descriptor: D-dopachrome decarboxylase Authors: Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. Deposit date: 2023-12-23 Release date: 2024-05-01 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.24 Å) Cite: The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
8VG8	Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT) Bound to 4CPPC Descriptor: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, D-dopachrome decarboxylase Authors: Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. Deposit date: 2023-12-23 Release date: 2024-05-01 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.33 Å) Cite: The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024

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