6DRH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6drh by Molmil](/molmil-images/mine/6drh) | ADP-ribosyltransferase toxin/immunity pair | Descriptor: | ADP-ribosyl-(Dinitrogen reductase) hydrolase, MAGNESIUM ION, PAAR repeat-containing protein, ... | Authors: | Bosch, D.E, Ting, S, Allaire, M, Mougous, J.D. | Deposit date: | 2018-06-11 | Release date: | 2018-10-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins. Cell, 175, 2018
|
|
6DCO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dco by Molmil](/molmil-images/mine/6dco) | Bcl-xL complex with Beclin 1 BH3 domain T108D | Descriptor: | Bcl-2-like protein 1,Bcl-2-like protein 1, Beclin-1, CHLORIDE ION | Authors: | Lee, E.F, Smith, B.J, Smith, N.A, Yao, S, Fairlie, W.D. | Deposit date: | 2018-05-07 | Release date: | 2018-05-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.198 Å) | Cite: | Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1. Autophagy, 15, 2019
|
|
6DCX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dcx by Molmil](/molmil-images/mine/6dcx) | iASPP-PP-1c structure and targeting of p53 | Descriptor: | RelA-associated inhibitor, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | Authors: | Glover, J.N.M, Zhou, Y, Edwards, R.A. | Deposit date: | 2018-05-08 | Release date: | 2019-05-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.408 Å) | Cite: | Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis. Structure, 27, 2019
|
|
2MJ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mj9 by Molmil](/molmil-images/mine/2mj9) | Designed Exendin-4 analogues | Descriptor: | Exendin-4 | Authors: | Rovo, P, Farkas, V, Straner, P, Szabo, M, Jermendy, A, Hegyi, O, Toth, G.K, Perczel, A. | Deposit date: | 2013-12-30 | Release date: | 2014-06-04 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Rational design of alpha-helix-stabilized exendin-4 analogues. Biochemistry, 53, 2014
|
|
2MLU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mlu by Molmil](/molmil-images/mine/2mlu) | |
2M0C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2m0c by Molmil](/molmil-images/mine/2m0c) | Solution NMR Structure of Homeobox Domain of Human ALX4, Northeast Structural Genomics Consortium (NESG) Target HR4490C | Descriptor: | Homeobox protein aristaless-like 4 | Authors: | Xu, X, Eletsky, A, Pulavarti, S, Lee, D, Janjua, H, Xiao, R, Acton, T.B, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-10-24 | Release date: | 2012-11-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of Homeobox Domain of Human ALX4, Northeast Structural Genomics Consortium (NESG) Target HR4490C To be Published
|
|
6DFT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dft by Molmil](/molmil-images/mine/6dft) | Trypanosoma brucei deoxyhypusine synthase | Descriptor: | Deoxyhypusine synthase, Deoxyhypusine synthase regulatory subunit, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Tomchick, D.R, Phillips, M.A, Afanador, G.A. | Deposit date: | 2018-05-15 | Release date: | 2018-08-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs. Structure, 26, 2018
|
|
6DKM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dkm by Molmil](/molmil-images/mine/6dkm) | DHD131 | Descriptor: | DHD131_A, DHD131_B | Authors: | Bick, M.J, Chen, Z, Baker, D. | Deposit date: | 2018-05-29 | Release date: | 2018-12-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
|
|
2MLV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mlv by Molmil](/molmil-images/mine/2mlv) | |
6DND
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dnd by Molmil](/molmil-images/mine/6dnd) | Crystal structure of wild-type (WT) human Glutamate oxaloacetate transaminase 1 (GOT1) | Descriptor: | Aspartate aminotransferase, cytoplasmic, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Assar, Z, Holt, M.C, Stein, A.J, Lairson, L, Lyssiotis, C.A. | Deposit date: | 2018-06-06 | Release date: | 2018-11-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry, 57, 2018
|
|
7C7L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7c7l by Molmil](/molmil-images/mine/7c7l) | Cryo-EM structure of the Cas12f1-sgRNA-target DNA complex | Descriptor: | CRISPR-associated protein Cas14a.1, DNA (40-mer), ZINC ION, ... | Authors: | Takeda, N.S, Nakagawa, R, Okazaki, S, Hirano, H, Kobayashi, K, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | Deposit date: | 2020-05-26 | Release date: | 2020-12-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the miniature type V-F CRISPR-Cas effector enzyme. Mol.Cell, 81, 2021
|
|
2MN6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mn6 by Molmil](/molmil-images/mine/2mn6) | |
6DPD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dpd by Molmil](/molmil-images/mine/6dpd) | |
1IYH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1iyh by Molmil](/molmil-images/mine/1iyh) | Crystal structure of hematopoietic prostaglandin D synthase | Descriptor: | GLUTATHIONE, HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, MAGNESIUM ION | Authors: | Inoue, T. | Deposit date: | 2002-08-26 | Release date: | 2003-04-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanism of metal activation of human hematopoietic prostaglandin D synthase NAT.STRUCT.BIOL., 10, 2003
|
|
2MB9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mb9 by Molmil](/molmil-images/mine/2mb9) | Human Bcl10 CARD | Descriptor: | B-cell lymphoma/leukemia 10 | Authors: | Zheng, C, Bracken, C, Wu, H. | Deposit date: | 2013-07-26 | Release date: | 2013-10-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly. Mol.Cell, 51, 2013
|
|
6DEK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dek by Molmil](/molmil-images/mine/6dek) | |
2M0H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2m0h by Molmil](/molmil-images/mine/2m0h) | SP-B C-terminal (residues 59-80) peptide in methanol | Descriptor: | Pulmonary surfactant-associated protein B | Authors: | Kuznetsova, A, Long, J.R. | Deposit date: | 2012-10-25 | Release date: | 2014-04-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR structures of the C-terminal segment of surfactant protein B (residues 59-80) in DPC detergent micelles and methanol. To be Published
|
|
6DER
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6der by Molmil](/molmil-images/mine/6der) | Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam | Descriptor: | (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, ... | Authors: | Garcia, M.D, Guddat, L.W. | Deposit date: | 2018-05-12 | Release date: | 2018-09-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.126 Å) | Cite: | Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
7CD8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cd8 by Molmil](/molmil-images/mine/7cd8) | GFP-40/GFPuv complex, Form II | Descriptor: | GFP-40, Green fluorescent protein | Authors: | Yasui, N, Yamashita, A. | Deposit date: | 2020-06-18 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A sweet protein monellin as a non-antibody scaffold for synthetic binding proteins. J.Biochem., 169, 2021
|
|
8T6L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t6l by Molmil](/molmil-images/mine/8t6l) | Cryo-EM structure of rat cardiac sodium channel NaV1.5 with batrachotoxin analog BTX-B | Descriptor: | (1R)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-9,12-dihydroxy-2,11a-dimethyl-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-7H-9,11b-epoxy-13a,5a-prop[1]enophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl benzoate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, ... | Authors: | Tonggu, L, Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | Deposit date: | 2023-06-16 | Release date: | 2024-03-06 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin. Nat Commun, 15, 2024
|
|
7CM1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cm1 by Molmil](/molmil-images/mine/7cm1) | Neuraminidase from the Wuhan Asiatic toad influenza virus | Descriptor: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, Neuraminidase | Authors: | Wang, J. | Deposit date: | 2020-07-23 | Release date: | 2020-11-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Lattice-translocation defects in specific crystals of the catalytic head domain of influenza neuraminidase. Acta Crystallogr D Struct Biol, 76, 2020
|
|
6DG7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dg7 by Molmil](/molmil-images/mine/6dg7) | Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, SEROTONIN, ... | Authors: | Basak, S, Chakrapani, S. | Deposit date: | 2018-05-17 | Release date: | 2018-11-07 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3Areceptor. Nature, 563, 2018
|
|
8C68
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8c68 by Molmil](/molmil-images/mine/8c68) | |
8SVP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8svp by Molmil](/molmil-images/mine/8svp) | Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-278 | Descriptor: | (1P)-N-(5-tert-butyl-2-{[(3R)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide | Authors: | Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. | Deposit date: | 2023-05-17 | Release date: | 2024-05-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
|
|
8SVU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8svu by Molmil](/molmil-images/mine/8svu) | Crystal structure of the L428V mutant of pregnane X receptor ligand binding domain in apo form | Descriptor: | GLYCEROL, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1 fusion protein,Nuclear receptor coactivator 1 | Authors: | Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. | Deposit date: | 2023-05-17 | Release date: | 2024-05-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
|
|