6DEK

Crystal structure of Candida albicans acetohydroxyacid synthase catalytic subunit

Summary for 6DEK

Entry DOI	10.2210/pdb6dek/pdb
Descriptor	Acetolactate synthase, FLAVIN-ADENINE DINUCLEOTIDE, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	ahas, acetohydroxyacid synthase, acetolactate synthase, herbicide, thiamin diphosphate, fad, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Total number of polymer chains	1
Total formula weight	75589.63
Authors	Garcia, M.D.,Guddat, L.W. (deposition date: 2018-05-12, release date: 2018-09-26, Last modification date: 2023-10-11)
Primary citation	Garcia, M.D.,Chua, S.M.H.,Low, Y.S.,Lee, Y.T.,Agnew-Francis, K.,Wang, J.G.,Nouwens, A.,Lonhienne, T.,Williams, C.M.,Fraser, J.A.,Guddat, L.W. Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proc. Natl. Acad. Sci. U.S.A., 115:E9649-E9658, 2018 Cited by PubMed: 30249642 DOI: 10.1073/pnas.1809422115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.971 Å)

Structure validation