8SVU
Crystal structure of the L428V mutant of pregnane X receptor ligand binding domain in apo form
Summary for 8SVU
| Entry DOI | 10.2210/pdb8svu/pdb |
| Descriptor | Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1 fusion protein,Nuclear receptor coactivator 1, GLYCEROL (3 entities in total) |
| Functional Keywords | pregnane x receptor (pxr), promiscuous ligand-activated protein, nuclear receptor subfamily 1, transcriptional regulator, drug metabolism, transcription |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 79855.30 |
| Authors | Garcia-Maldonado, E.,Huber, A.D.,Nithianantham, S.,Miller, D.J.,Chen, T. (deposition date: 2023-05-17, release date: 2024-05-15, Last modification date: 2024-06-05) |
| Primary citation | Garcia-Maldonado, E.,Huber, A.D.,Chai, S.C.,Nithianantham, S.,Li, Y.,Wu, J.,Poudel, S.,Miller, D.J.,Seetharaman, J.,Chen, T. Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15:4054-4054, 2024 Cited by PubMed: 38744881DOI: 10.1038/s41467-024-48472-1 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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