7Q4N
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5BPU
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![BU of 5bpu by Molmil](/molmil-images/mine/5bpu) | Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I | Descriptor: | (GGL)EEE, (GGL)EEEEEE, Norrin | Authors: | Chang, T.-H, Hsieh, F.-L, Harlos, K, Jones, E.Y. | Deposit date: | 2015-05-28 | Release date: | 2015-07-01 | Last modified: | 2019-07-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan. Elife, 4, 2015
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7PTV
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![BU of 7ptv by Molmil](/molmil-images/mine/7ptv) | Structure of the Mimivirus genomic fibre asymmetric unit | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Putative glucose-methanol-choline oxidoreductase protein | Authors: | Villalta, A, Schmitt, A, Estrozi, L.F, Quemin, E.R.J, Alempic, J.M, Lartigue, A, Prazak, V, Belmudes, L, Vasishtan, D, Colmant, A.M.G, Honore, F.A, Coute, Y, Grunewald, K, Abergel, C. | Deposit date: | 2021-09-27 | Release date: | 2022-08-10 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The giant mimivirus 1.2 Mb genome is elegantly organized into a 30 nm diameter helical protein shield. Elife, 11, 2022
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7PWT
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![BU of 7pwt by Molmil](/molmil-images/mine/7pwt) | Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptor alpha phosphopeptide, stabilised by pyrrolidone derivative 228 | Descriptor: | (2~{R})-1-(2-hydroxyphenyl)-2-(4-nitrophenyl)-4-oxidanyl-3-(phenylcarbonyl)-2~{H}-pyrrol-5-one, 14-3-3 protein sigma, C-terminus of Estrogen receptor alpha, ... | Authors: | Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. | Deposit date: | 2021-10-07 | Release date: | 2022-12-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.312 Å) | Cite: | Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
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6S9T
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![BU of 6s9t by Molmil](/molmil-images/mine/6s9t) | Dimerization domain of Xenopus laevis LDB1 in complex with darpin 3 | Descriptor: | Darpin 3, LIM domain-binding protein 1, TETRAETHYLENE GLYCOL | Authors: | Renko, M, Schaefer, J.V, Pluckthun, A, Bienz, M. | Deposit date: | 2019-07-15 | Release date: | 2019-10-09 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proc.Natl.Acad.Sci.USA, 116, 2019
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7PWZ
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![BU of 7pwz by Molmil](/molmil-images/mine/7pwz) | Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptoralpha phosphopeptide, stabilised by Pyrrolidone1 derivative 228 | Descriptor: | 14-3-3 protein sigma, 2-oxidanyl-5-[(2~{R})-4-oxidanyl-5-oxidanylidene-2-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]benzoic acid, C-terminus of Estrogen receptor alpha, ... | Authors: | Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. | Deposit date: | 2021-10-07 | Release date: | 2022-12-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
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6V0O
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![BU of 6v0o by Molmil](/molmil-images/mine/6v0o) | PRMT5 bound to the PBM peptide from pICln | Descriptor: | ACETYL GROUP, Methylosome protein 50, PBM peptide, ... | Authors: | McMillan, B.J, Raymond, D.D. | Deposit date: | 2019-11-19 | Release date: | 2020-08-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol.Cell, 81, 2021
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5BQB
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![BU of 5bqb by Molmil](/molmil-images/mine/5bqb) | Crystal structure of Norrin, a Wnt signalling activator, Crystal Form III | Descriptor: | CHLORIDE ION, CITRIC ACID, Norrin | Authors: | Chang, T.-H, Hsieh, F.-L, Harlos, K, Jones, E.Y. | Deposit date: | 2015-05-28 | Release date: | 2015-07-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan. Elife, 4, 2015
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7Q8T
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![BU of 7q8t by Molmil](/molmil-images/mine/7q8t) | Crystal structure of NAMPT bound to ligand TSY535(compound 9a) | Descriptor: | Nicotinamide phosphoribosyltransferase, SULFATE ION, [(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Kraemer, A, Tang, S, Butterworth, S, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2021-11-11 | Release date: | 2021-11-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators. Acta Pharm Sin B, 13, 2023
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5CL1
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![BU of 5cl1 by Molmil](/molmil-images/mine/5cl1) | Complex structure of Norrin with human Frizzled 4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, Maltose-binding periplasmic protein,Norrin | Authors: | Wang, Z, Ke, J, Shen, G, Cheng, Z, Xu, H.E, Xu, W. | Deposit date: | 2015-07-16 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural basis of the Norrin-Frizzled 4 interaction. Cell Res., 25, 2015
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7YNQ
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7YNT
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7QIK
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![BU of 7qik by Molmil](/molmil-images/mine/7qik) | SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma | Descriptor: | 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ... | Authors: | Sluchanko, N.N, Tugaeva, K.V, Smith, J.L.R, Antson, A.A. | Deposit date: | 2021-12-15 | Release date: | 2021-12-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma To Be Published
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7YNM
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![BU of 7ynm by Molmil](/molmil-images/mine/7ynm) | ThT-bound alpha-synuclein fibrils conformation 1 | Descriptor: | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, Alpha-synuclein | Authors: | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | Deposit date: | 2022-07-31 | Release date: | 2023-08-02 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | ThT-bound alpha-synuclein fibrils conformation 1 To Be Published
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7QIP
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7YNR
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7YNL
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![BU of 7ynl by Molmil](/molmil-images/mine/7ynl) | EB-bound alpha-synuclein fibrils | Descriptor: | 4-azanyl-6-[[4-[4-[(~{E})-(8-azanyl-1-oxidanyl-5,7-disulfo-naphthalen-2-yl)diazenyl]-3-methyl-phenyl]-2-methyl-phenyl]diazenyl]-5-oxidanyl-naphthalene-1,3-disulfonic acid, Alpha-synuclein | Authors: | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | Deposit date: | 2022-07-31 | Release date: | 2023-08-02 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | EB-bound alpha-synuclein fibrils To Be Published
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7YNP
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![BU of 7ynp by Molmil](/molmil-images/mine/7ynp) | BF227-bound alpha-synuclein fibrils | Descriptor: | 5-[(~{E})-2-(6-methoxy-1,3-benzoxazol-2-yl)ethenyl]-~{N},~{N}-dimethyl-1,3-thiazol-2-amine, Alpha-synuclein | Authors: | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | Deposit date: | 2022-07-31 | Release date: | 2023-08-02 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | BF227-bound alpha-synuclein fibrils To Be Published
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7YNN
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![BU of 7ynn by Molmil](/molmil-images/mine/7ynn) | ThT-bound alpha-synuclein fibrils conformation 2 | Descriptor: | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, Alpha-synuclein | Authors: | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | Deposit date: | 2022-07-31 | Release date: | 2023-08-02 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | ThT-bound alpha-synuclein fibrils conformation 2 To Be Published
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7YNO
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7YNS
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7YNG
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6UXX
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![BU of 6uxx by Molmil](/molmil-images/mine/6uxx) | PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 1a | Descriptor: | (5R)-2-amino-5-(4-methoxyphenyl)-3-methyl-5-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-yl]-3,5-dihydro-4H-imidazol-4-one, Methylosome protein 50, Protein arginine N-methyltransferase 5 | Authors: | Palte, R.L, Schneider, S.E. | Deposit date: | 2019-11-08 | Release date: | 2020-08-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11, 2020
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6P5O
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1X86
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