6I5Y
 
 | | Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-adenosine | | Descriptor: | 1,2-ETHANEDIOL, 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, Tyrosine--tRNA ligase | | Authors: | De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. | | Deposit date: | 2018-11-15 | | Release date: | 2019-04-17 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
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6HB6
 | | Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-uridine | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Tyrosine--tRNA ligase, ... | | Authors: | De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. | | Deposit date: | 2018-08-09 | | Release date: | 2019-04-17 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
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7ELE
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7ELD
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7YDG
 | | Crystal structure of human SARS2 catalytic domain with a disease related mutation | | Descriptor: | Serine--tRNA ligase, mitochondrial | | Authors: | Wu, S, Li, P, Zhou, X.L, Fang, P. | | Deposit date: | 2022-07-04 | | Release date: | 2022-11-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Selective degradation of tRNASer(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease.
Nucleic Acids Res., 50, 2022
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7YDF
 | | Crystal structure of human SARS2 catalytic domain | | Descriptor: | Serine--tRNA ligase, mitochondrial | | Authors: | Wu, S, Li, P, Zhou, X.L, Fang, P. | | Deposit date: | 2022-07-04 | | Release date: | 2022-11-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Selective degradation of tRNASer(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease.
Nucleic Acids Res., 50, 2022
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3W1K
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5OBN
 | | NMR solution structure of U11/U12 65K protein's C-terminal RRM domain (381-516) | | Descriptor: | RNA-binding protein 40 | | Authors: | Norppa, A.J, Kauppala, T.M, Heikkinen, H.A, Verma, B, Iwai, H, Frilander, M.J. | | Deposit date: | 2017-06-28 | | Release date: | 2018-01-24 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA.
RNA, 24, 2018
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1IQ4
 | | 5S-RRNA BINDING RIBOSOMAL PROTEIN L5 FROM BACILLUS STEAROTHERMOPHILUS | | Descriptor: | 50S RIBOSOMAL PROTEIN L5 | | Authors: | Nakashima, T, Yao, M, Kawamura, S, Iwasaki, K, Kimura, M, Tanaka, I. | | Deposit date: | 2001-06-13 | | Release date: | 2001-06-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Ribosomal protein L5 has a highly twisted concave surface and flexible arms responsible for rRNA binding.
RNA, 7, 2001
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2BU1
 | | MS2-RNA HAIRPIN (5BRU -5) COMPLEX | | Descriptor: | 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *5BU*AP*CP*CP*CP*AP*UP*GP*U)-3', MS2 COAT PROTEIN | | Authors: | Grahn, E, Moss, T, Helgstrand, C, Fridborg, K, Sundaram, M, Tars, K, Lago, H, Stonehouse, N.J, Davis, D.R, Stockley, P.G, Liljas, L. | | Deposit date: | 2005-06-08 | | Release date: | 2005-08-18 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis of pyrimidine specificity in the MS2 RNA hairpin-coat-protein complex.
Rna, 7, 2001
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2C4Q
 | | MS2-RNA HAIRPIN (2ONE -5) COMPLEX | | Descriptor: | 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *PYO*AP*CP*CP*CP*AP*UP*GP*U)-3', COAT PROTEIN | | Authors: | Grahn, E, Moss, T, Helgstrand, C, Fridborg, K, Sundaram, M, Tars, K, Lago, H, Stonehouse, N.J, Davis, D.R, Stockley, P.G, Liljas, L. | | Deposit date: | 2005-10-21 | | Release date: | 2005-11-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Structural basis of pyrimidine specificity in the MS2 RNA hairpin-coat-protein complex.
Rna, 7, 2001
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8PTW
 | | Chaetomium thermophilum Rix1-complex | | Descriptor: | Pre-rRNA-processing protein IPI3, Pre-rRNA-processing protein RIX1 | | Authors: | Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. | | Deposit date: | 2023-07-15 | | Release date: | 2023-11-15 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.
Embo Rep., 24, 2023
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2C4Y
 | | MS2-RNA HAIRPIN (2THIOURACIL-5) COMPLEX | | Descriptor: | 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *SUR*AP*CP*CP*CP*AP*UP*GP*U)-3', Capsid protein | | Authors: | Grahn, E, Moss, T, Helgstrand, C, Fridborg, K, Sundaram, M, Tars, K, Lago, H, Stonehouse, N.J, Davis, D.R, Stockley, P.G, Liljas, L. | | Deposit date: | 2005-10-25 | | Release date: | 2006-01-05 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Structural basis of pyrimidine specificity in the MS2 RNA hairpin-coat-protein complex.
Rna, 7, 2001
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4JYA
 | | Crystal structures of pseudouridinilated stop codons with ASLs | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | Deposit date: | 2013-03-29 | | Release date: | 2013-06-26 | | Last modified: | 2013-08-21 | | Method: | X-RAY DIFFRACTION (3.098 Å) | | Cite: | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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4JV5
 | | Crystal structures of pseudouridinilated stop codons with ASLs | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein 20, 30S ribosomal protein S10, ... | | Authors: | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | Deposit date: | 2013-03-25 | | Release date: | 2013-06-26 | | Last modified: | 2013-08-21 | | Method: | X-RAY DIFFRACTION (3.162 Å) | | Cite: | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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2C50
 | | MS2-RNA HAIRPIN (A -5) COMPLEX | | Descriptor: | 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *AP*AP*CP*CP*CP*AP*UP*GP*U)-3', COAT PROTEIN | | Authors: | Grahn, E, Moss, T, Helgstrand, C, Fridborg, K, Sundaram, M, Tars, K, Lago, H, Stonehouse, N.J, Davis, D.R, Stockley, P.G, Liljas, L. | | Deposit date: | 2005-10-25 | | Release date: | 2006-01-05 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural basis of pyrimidine specificity in the MS2 RNA hairpin-coat-protein complex.
Rna, 7, 2001
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2C51
 | | MS2-RNA HAIRPIN (G -5) COMPLEX | | Descriptor: | 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *GP*AP*CP*CP*CP*AP*UP*GP*U)-3', COAT PROTEIN | | Authors: | Grahn, E, Moss, T, Helgstrand, C, Fridborg, K, Sundaram, M, Tars, K, Lago, H, Stonehouse, N.J, Davis, D.R, Stockley, P.G, Liljas, L. | | Deposit date: | 2005-10-25 | | Release date: | 2006-01-05 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of pyrimidine specificity in the MS2 RNA hairpin-coat-protein complex.
Rna, 7, 2001
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4C3I
 | | Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135, ... | | Authors: | Fernandez-Tornero, C, Moreno-Morcillo, M, Rashid, U.J, Taylor, N.M.I, Ruiz, F.M, Gruene, T, Legrand, P, Steuerwald, U, Muller, C.W. | | Deposit date: | 2013-08-24 | | Release date: | 2013-10-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structure of the 14-Subunit RNA Polymerase I
Nature, 502, 2013
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2C4Z
 | | MS2-RNA HAIRPIN (2SU -5-6) COMPLEX | | Descriptor: | 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*SUR *SUR*AP*CP*CP*CP*AP*UP*GP*U)-3', COAT PROTEIN | | Authors: | Grahn, E, Moss, T, Helgstrand, C, Fridborg, K, Sundaram, M, Tars, K, Lago, H, Stonehouse, N.J, Davis, D.R, Stockley, P.G, Liljas, L. | | Deposit date: | 2005-10-25 | | Release date: | 2006-01-05 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of pyrimidine specificity in the MS2 RNA hairpin-coat-protein complex.
Rna, 7, 2001
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4C3J
 | | Structure of 14-subunit RNA polymerase I at 3.35 A resolution, crystal form C2-90 | | Descriptor: | DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14, ... | | Authors: | Fernandez-Tornero, C, Moreno-Morcillo, M, Rashid, U.J, Taylor, N.M.I, Ruiz, F.M, Gruene, T, Legrand, P, Steuerwald, U, Muller, C.W. | | Deposit date: | 2013-08-24 | | Release date: | 2013-10-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Crystal Structure of the 14-Subunit RNA Polymerase I
Nature, 502, 2013
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4C3H
 | | Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93 | | Descriptor: | DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14, ... | | Authors: | Fernandez-Tornero, C, Moreno-Morcillo, M, Rashid, U.J, Taylor, N.M.I, Ruiz, F.M, Gruene, T, Legrand, P, Steuerwald, U, Muller, C.W. | | Deposit date: | 2013-08-24 | | Release date: | 2013-10-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.27 Å) | | Cite: | Crystal Structure of the 14-Subunit RNA Polymerase I
Nature, 502, 2013
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1TYC
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1TTT
 | | Phe-tRNA, elongation factoR EF-TU:GDPNP ternary complex | | Descriptor: | MAGNESIUM ION, OF ELONGATION FACTOR TU (EF-TU), PHENYLALANINE, ... | | Authors: | Nissen, P, Kjeldgaard, M, Thirup, S, Polekhina, G, Reshetnikova, L, Clark, B.F.C, Nyborg, J. | | Deposit date: | 1995-11-16 | | Release date: | 1996-12-23 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog.
Science, 270, 1995
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6N0W
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8P1Y
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