8OPP

Structure of human terminal uridylyltransferase 7 (hTUT7/ZCCHC6) bound with pre-let7g miRNA and UTPalphaS

Summary for 8OPP

• Entry DOI: 10.2210/pdb8opp/pdb
• EMDB information: 17084
• Descriptor: Terminal uridylyltransferase 7, RNA (25-MER), [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl] phosphono hydrogen phosphate (3 entities in total)
• Functional Keywords: polymerase, uridylation, rna maturation and turnover control, rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 180001.74

Authors

Yi, G.,Ye, M.,Gilbert, R.J. (deposition date: 2023-04-07, release date: 2024-07-24, Last modification date: 2024-08-07)

• Primary citation: Yi, G.,Ye, M.,Carrique, L.,El-Sagheer, A.,Brown, T.,Norbury, C.J.,Zhang, P.,Gilbert, R.J.C.; Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs.; Nat.Struct.Mol.Biol., 2024; PubMed: 39054354; DOI: 10.1038/s41594-024-01357-9

Experimental method

ELECTRON MICROSCOPY (3.76 Å)