4J75
Crystal Structure of a parasite tRNA synthetase, product-bound
Summary for 4J75
Entry DOI | 10.2210/pdb4j75/pdb |
Related | 4J75 |
Descriptor | Tryptophanyl-tRNA synthetase, TRYPTOPHANYL-5'AMP, GLYCEROL, ... (4 entities in total) |
Functional Keywords | aminoacyl-trna synthetase, aars, trprs, parasite, protein-substrate complex, rossmann fold, translation, nucleotide binding, ligase |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 2 |
Total formula weight | 95684.52 |
Authors | Koh, C.Y.,Kim, J.E.,Verlinde, C.L.M.J.,Hol, W.G.J. (deposition date: 2013-02-12, release date: 2013-05-22, Last modification date: 2023-09-20) |
Primary citation | Koh, C.Y.,Kim, J.E.,Napoli, A.J.,Verlinde, C.L.,Fan, E.,Buckner, F.S.,Van Voorhis, W.C.,Hol, W.G. Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol.Biochem.Parasitol., 189:26-32, 2013 Cited by PubMed: 23665145DOI: 10.1016/j.molbiopara.2013.04.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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