6JLY
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![BU of 6jly by Molmil](/molmil-images/mine/6jly) | eIF2a - eIF2B complex | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, PHOSPHATE ION, Probable translation initiation factor eIF-2B subunit beta, ... | Authors: | Kashiwagi, K, Ito, T. | Deposit date: | 2019-03-07 | Release date: | 2019-05-01 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural basis for eIF2B inhibition in integrated stress response. Science, 364, 2019
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7F67
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![BU of 7f67 by Molmil](/molmil-images/mine/7f67) | eIF2B-SFSV NSs-2-eIF2 | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, Non-structural protein NS-S, ... | Authors: | Kashiwagi, K, Ito, T. | Deposit date: | 2021-06-24 | Release date: | 2021-12-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | eIF2B-capturing viral protein NSs suppresses the integrated stress response. Nat Commun, 12, 2021
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7F66
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![BU of 7f66 by Molmil](/molmil-images/mine/7f66) | eIF2B-SFSV NSs-1-eIF2 | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, Non-structural protein NS-S, ... | Authors: | Kashiwagi, K, Ito, T. | Deposit date: | 2021-06-24 | Release date: | 2021-12-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | eIF2B-capturing viral protein NSs suppresses the integrated stress response. Nat Commun, 12, 2021
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7F64
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![BU of 7f64 by Molmil](/molmil-images/mine/7f64) | eIF2B-SFSV NSs | Descriptor: | Non-structural protein NS-S, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | Authors: | Kashiwagi, K, Ito, T. | Deposit date: | 2021-06-24 | Release date: | 2021-12-08 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.42 Å) | Cite: | eIF2B-capturing viral protein NSs suppresses the integrated stress response. Nat Commun, 12, 2021
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7FB7
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![BU of 7fb7 by Molmil](/molmil-images/mine/7fb7) | Crystal structure of human UHRF1 TTD in complex with 5-amino-2,4-dimethylpyridine | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-amino-2,4-dimethylpyridine, DIMETHYL SULFOXIDE, ... | Authors: | Kori, S, Arita, K, Yoshimi, S. | Deposit date: | 2021-07-08 | Release date: | 2022-01-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1. Bioorg.Med.Chem., 52, 2021
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6I0N
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![BU of 6i0n by Molmil](/molmil-images/mine/6i0n) | |
7FBR
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![BU of 7fbr by Molmil](/molmil-images/mine/7fbr) | |
1C8N
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![BU of 1c8n by Molmil](/molmil-images/mine/1c8n) | TOBACCO NECROSIS VIRUS | Descriptor: | CALCIUM ION, COAT PROTEIN | Authors: | Oda, Y, Fukuyama, K. | Deposit date: | 2000-05-20 | Release date: | 2000-08-30 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal structure of tobacco necrosis virus at 2.25 A resolution. J.Mol.Biol., 300, 2000
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7F5K
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![BU of 7f5k by Molmil](/molmil-images/mine/7f5k) | Crystal structure of TCR4-1 ectodomain | Descriptor: | T cell receptor alpha chain, T cell receptor beta chain | Authors: | Nagae, M, Yamasaki, S. | Deposit date: | 2021-06-22 | Release date: | 2022-06-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.0000298 Å) | Cite: | Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b. Nat Commun, 13, 2022
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6IP5
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![BU of 6ip5 by Molmil](/molmil-images/mine/6ip5) | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | Deposit date: | 2018-11-02 | Release date: | 2019-05-29 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
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6I09
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![BU of 6i09 by Molmil](/molmil-images/mine/6i09) | |
6I0A
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![BU of 6i0a by Molmil](/molmil-images/mine/6i0a) | |
6IP6
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![BU of 6ip6 by Molmil](/molmil-images/mine/6ip6) | Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | Deposit date: | 2018-11-02 | Release date: | 2019-05-29 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
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6IP8
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![BU of 6ip8 by Molmil](/molmil-images/mine/6ip8) | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | Deposit date: | 2018-11-02 | Release date: | 2019-05-29 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
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7JLQ
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![BU of 7jlq by Molmil](/molmil-images/mine/7jlq) | cryo-EM structure of human ATG9A in LMNG micelles | Descriptor: | Autophagy-related protein 9A | Authors: | Maeda, S, Otomo, T. | Deposit date: | 2020-07-30 | Release date: | 2020-10-28 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure, lipid scrambling activity and role in autophagosome formation of ATG9A. Nat.Struct.Mol.Biol., 27, 2020
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7JLP
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![BU of 7jlp by Molmil](/molmil-images/mine/7jlp) | cryo-EM structure of human ATG9A in nanodiscs | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Autophagy-related protein 9A | Authors: | Maeda, S, Otomo, T. | Deposit date: | 2020-07-30 | Release date: | 2020-10-28 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure, lipid scrambling activity and role in autophagosome formation of ATG9A. Nat.Struct.Mol.Biol., 27, 2020
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7JLO
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![BU of 7jlo by Molmil](/molmil-images/mine/7jlo) | Cryo-EM structure of human ATG9A in amphipols | Descriptor: | Autophagy-related protein 9A | Authors: | Maeda, S, Otomo, T. | Deposit date: | 2020-07-30 | Release date: | 2020-10-28 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure, lipid scrambling activity and role in autophagosome formation of ATG9A. Nat.Struct.Mol.Biol., 27, 2020
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6K0R
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![BU of 6k0r by Molmil](/molmil-images/mine/6k0r) | Ruvbl1-Ruvbl2 with truncated domain II in complex with phosphorylated Cordycepin | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Zhang, W, Chen, L, Li, W, Ju, D, Huang, N, Zhang, E. | Deposit date: | 2019-05-07 | Release date: | 2020-05-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals. Sci Transl Med, 12, 2020
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6K71
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![BU of 6k71 by Molmil](/molmil-images/mine/6k71) | eIF2 - eIF2B complex | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | Authors: | Kashiwagi, K, Yokoyama, T, Ito, T. | Deposit date: | 2019-06-05 | Release date: | 2019-07-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis for eIF2B inhibition in integrated stress response. Science, 364, 2019
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1GZA
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![BU of 1gza by Molmil](/molmil-images/mine/1gza) | PEROXIDASE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, IODIDE ION, ... | Authors: | Fukuyama, K, Itakura, H. | Deposit date: | 1996-11-13 | Release date: | 1997-03-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Binding of iodide to Arthromyces ramosus peroxidase investigated with X-ray crystallographic analysis, 1H and 127I NMR spectroscopy, and steady-state kinetics. J.Biol.Chem., 272, 1997
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6K72
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![BU of 6k72 by Molmil](/molmil-images/mine/6k72) | eIF2(aP) - eIF2B complex | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | Authors: | Kashiwagi, K, Yokoyama, T, Ito, T. | Deposit date: | 2019-06-05 | Release date: | 2019-07-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural basis for eIF2B inhibition in integrated stress response. Science, 364, 2019
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7FBV
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![BU of 7fbv by Molmil](/molmil-images/mine/7fbv) | |
6I05
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![BU of 6i05 by Molmil](/molmil-images/mine/6i05) | |
7JWW
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![BU of 7jww by Molmil](/molmil-images/mine/7jww) | Crystal structure of human ALDH1A1 bound to compound (R)-28 | Descriptor: | 5-{4-[(Z)-2-hydroxyethenyl]phenyl}-1-methyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, CHLORIDE ION, Retinal dehydrogenase 1, ... | Authors: | Hurley, T.D, Buchman, C. | Deposit date: | 2020-08-26 | Release date: | 2020-12-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy. Eur.J.Med.Chem., 211, 2020
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7JY3
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![BU of 7jy3 by Molmil](/molmil-images/mine/7jy3) | Structure of HbA with compound 23 (PF-07059013) | Descriptor: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 6-{(1S)-1-[(2-amino-6-fluoroquinolin-3-yl)oxy]ethyl}-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one, Hemoglobin subunit alpha, ... | Authors: | Jasti, J. | Deposit date: | 2020-08-28 | Release date: | 2021-01-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease. J.Med.Chem., 64, 2021
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