7JY3

Structure of HbA with compound 23 (PF-07059013)

Summary for 7JY3

Entry DOI	10.2210/pdb7jy3/pdb
Descriptor	Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
Functional Keywords	hemoglobin, oxygen transport
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	66727.34
Authors	Jasti, J. (deposition date: 2020-08-28, release date: 2021-01-13, Last modification date: 2023-10-18)
Primary citation	Gopalsamy, A.,Aulabaugh, A.E.,Barakat, A.,Beaumont, K.C.,Cabral, S.,Canterbury, D.P.,Casimiro-Garcia, A.,Chang, J.S.,Chen, M.Z.,Choi, C.,Dow, R.L.,Fadeyi, O.O.,Feng, X.,France, S.P.,Howard, R.M.,Janz, J.M.,Jasti, J.,Jasuja, R.,Jones, L.H.,King-Ahmad, A.,Knee, K.M.,Kohrt, J.T.,Limberakis, C.,Liras, S.,Martinez, C.A.,McClure, K.F.,Narayanan, A.,Narula, J.,Novak, J.J.,O'Connell, T.N.,Parikh, M.D.,Piotrowski, D.W.,Plotnikova, O.,Robinson, R.P.,Sahasrabudhe, P.V.,Sharma, R.,Thuma, B.A.,Vasa, D.,Wei, L.,Wenzel, A.Z.,Withka, J.M.,Xiao, J.,Yayla, H.G. PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease. J.Med.Chem., 64:326-342, 2021 Cited by PubMed: 33356244 DOI: 10.1021/acs.jmedchem.0c01518 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation