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4WI7	Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H435A Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region Authors: Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. Deposit date: 2014-09-25 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
8J6F	Cryo-EM structure of the Tocilizumab Fab/IL-6R complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Tocilizumab Fab, IL6R-D2 peptide, ... Authors: She, J, Chen, L. Deposit date: 2023-04-25 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cryo-EM structures of tocilizumab and sarilumab Fabs in complex with IL-6R To Be Published
4WI5	Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H310A Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region Authors: Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. Deposit date: 2014-09-25 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
4WY7	Crystal structure of recombinant 4E10 expressed in Escherichia coli with epitope bound Descriptor: Envelope glycoprotein gp160, Fab 4E10 Heavy chain, Fab 4E10Light chain, ... Authors: Rujas, E, Morante, K, Tsumoto, K, Nieva, J.L, Caaveiro, J.M.M. Deposit date: 2014-11-16 Release date: 2015-03-25 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region. J.Biol.Chem., 290, 2015
8IUZ	H7N9 HA-2D7 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2D7 Fab heavy chain, 2D7 Fab light chain, ... Authors: Zhao, B.B, Sun, Z.Z. Deposit date: 2023-03-25 Release date: 2024-04-24 Method: ELECTRON MICROSCOPY (3 Å) Cite: H7N9 HA-2D7 Fab To Be Published
8IUY	H7N9 HA-1H9 Fab Descriptor: 1H9 Fab heavy chain, 1H9 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Zhao, B.B, Sun, Z.Z. Deposit date: 2023-03-25 Release date: 2024-04-24 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: H7N9 HA-1H9 Fab To Be Published
8IV0	H7N9 HA-C4H4 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C4H4 Fab heavy chain, C4H4 Fab light chain, ... Authors: Zhao, B.B, Sun, Z.Z. Deposit date: 2023-03-25 Release date: 2024-04-24 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: H7N9 HA-C4H4 Fab To Be Published
1IJN	Crystal structure of the transthyretin mutant TTR C10A/Y114C Descriptor: BETA-MERCAPTOETHANOL, TRANSTHYRETIN Authors: Eneqvist, T, Karlsson, A, Olofsson, A, Sauer-Eriksson, A.E. Deposit date: 2001-04-27 Release date: 2003-06-03 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cys114-linked dimers of transthyretin are compatible with amyloid formation Biochemistry, 44, 2005
1III	CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR Y114C-DATA COLLECTED AT ROOM TEMPERATURE Descriptor: BETA-MERCAPTOETHANOL, TRANSTHYRETIN Authors: Eneqvist, T, Olofsson, A, Ando, Y, Lundgren, E, Sauer-Eriksson, A.E. Deposit date: 2001-04-23 Release date: 2002-11-15 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Disulfide-Bond Formation in the Transthyretin Mutant Y114C Prevents Amyloid Fibril Formation in Vivo and in Vitro Biochemistry, 41, 2002
8OL9	Anti-FIXa Fab in complex with human des-(Gla-EGF1) FIXa Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Coagulation factor IX heavy chain, ... Authors: Johansson, E, Svensson, L.A. Deposit date: 2023-03-30 Release date: 2023-07-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Computational design of N-linked glycans for high throughput epitope profiling. Protein Sci., 32, 2023
5ETU	Cetuximab Fab in complex with L5E meditope variant Descriptor: Cetuximab Fab heavy chain, Cetuximab Fab light chain, L5E meditope variant, ... Authors: Bzymek, K.P, Williams, J.C. Deposit date: 2015-11-18 Release date: 2016-10-26 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
6JP2	Crystal structure of pyrrolysyl-tRNA synthetase from Methanomethylophilus alvus Descriptor: Pyrrolysyl-tRNA synthetase Authors: Yanagisawa, T, Kuratani, M, Yokoyama, S. Deposit date: 2019-03-25 Release date: 2019-05-22 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.272 Å) Cite: Fully Productive Cell-Free Genetic Code Expansion by Structure-Based Engineering ofMethanomethylophilus alvusPyrrolysyl-tRNA Synthetase. Acs Synth Biol, 9, 2020
1IJS	CPV (STRAIN D) mutant A300D, complex (VIRAL COAT/DNA), VP2, PH=7.5, T=4 DEGREES C Descriptor: DNA (5'-D(*AP*C)-3'), DNA (5'-D(*CP*CP*AP*CP*CP*CP*CP*AP*A)-3'), PROTEIN (PARVOVIRUS COAT PROTEIN) Authors: Llamas-Saiz, A.L, Agbandje-McKenna, M, Parker, J.S.L, Wahid, A.T.M, Parrish, C.R, Rossmann, M.G. Deposit date: 1996-09-12 Release date: 1996-12-23 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structural analysis of a mutation in canine parvovirus which controls antigenicity and host range. Virology, 225, 1996
1QLY	NMR Study of the SH3 Domain From Bruton's Tyrosine Kinase, 20 Structures Descriptor: TYROSINE-PROTEIN KINASE BTK Authors: Tzeng, S.R, Lou, Y.C, Pai, M.T, Chen, C, Chen, S.H, Cheng, J.Y. Deposit date: 1999-09-20 Release date: 1999-12-14 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution Structure of the Human Btk SH3 Domain Complexed with a Proline-Rich Peptide from P120Cbl J.Biomol.NMR, 16, 2000
4XAV	Crystal structure of olfactomedin domain from gliomedin Descriptor: GLYCEROL, Gliomedin, PHOSPHATE ION, ... Authors: Hill, S.E, Nguyen, E, Lieberman, R.L. Deposit date: 2014-12-15 Release date: 2015-07-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.052 Å) Cite: Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies. Plos One, 10, 2015
4XAT	Crystal structure of the olfactomedin domain from noelin/pancortin/olfactomedin-1 Descriptor: CALCIUM ION, GLYCEROL, Noelin, ... Authors: Hill, S.E, Nguyen, E, Lieberman, R.L. Deposit date: 2014-12-15 Release date: 2015-07-15 Last modified: 2022-03-30 Method: X-RAY DIFFRACTION (2.113 Å) Cite: Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies. Plos One, 10, 2015
1IIK	CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR Y114C-DATA COLLECTED AT CRYO TEMPERATURE Descriptor: BETA-MERCAPTOETHANOL, TRANSTHYRETIN Authors: Eneqvist, T, Olofsson, A, Ando, Y, Lundgren, E, Sauer-Eriksson, A.E. Deposit date: 2001-04-23 Release date: 2002-11-15 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Disulfide-Bond Formation in the Transthyretin Mutant Y114C Prevents Amyloid Fibril Formation in Vivo and in Vitro Biochemistry, 41, 2002
5FUZ	Extending the half-life of a Fab fragment through generation of a humanised anti-Human Serum Albumin (HSA) Fv domain: an investigation into the correlation between affinity and serum half-life Descriptor: 645 FAB, HEAVY CHAIN, LIGHT CHAIN Authors: Adams, R, Ceska, T. Deposit date: 2016-02-01 Release date: 2016-06-29 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life. Mabs, 8, 2016
5G5R	CBS domain tandem of site-2 protease from Archaeoglobus fulgidus in complex with llama Nanobody - apo form Descriptor: NANOBODY, SITE-2 PROTEASE, SULFATE ION Authors: Schacherl, M, Baumann, U. Deposit date: 2016-06-02 Release date: 2017-05-24 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease. Biochim. Biophys. Acta, 1859, 2017
5GHK	Crystal Structure Analysis of Canine serum albumin Descriptor: Serum albumin Authors: Kihira, K, Yamada, K, Kureishi, M, Yokomaku, K, Shinohara, R, Akiyama, M, Komatsu, T. Deposit date: 2016-06-20 Release date: 2016-11-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Artificial Blood for Dogs Sci Rep, 6, 2016
6JLI	Crystal structure of CTLD7 domain of human PLA2R Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Secretory phospholipase A2 receptor Authors: Yu, B, Hu, Z, Kong, D, Cheng, C, He, Y. Deposit date: 2019-03-06 Release date: 2019-07-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.778 Å) Cite: Crystal structure of the CTLD7 domain of human M-type phospholipase A2 receptor. J.Struct.Biol., 207, 2019
5YQ0	Crystal structure of secreted protein CofJ from ETEC. Descriptor: CALCIUM ION, CofJ Authors: Oki, H, Kawahara, K, Maruno, T, Imai, T, Muroga, Y, Fukakusa, S, Iwashita, T, Kobayashi, Y, Matsuda, S, Kodama, T, Iida, T, Yoshida, T, Ohkubo, T, Nakamura, S. Deposit date: 2017-11-04 Release date: 2018-06-27 Last modified: 2018-07-25 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Interplay of a secreted protein with type IVb pilus for efficient enterotoxigenicEscherichia colicolonization Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1DXZ	M2 TRANSMEMBRANE SEGMENT OF ALPHA-SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA, NMR, 20 STRUCTURES Descriptor: ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA CHAIN Authors: Pashkov, V.S, Maslennikov, I.V, Tchikin, L.D, Efremov, R.G, Ivanov, V.T, Arseniev, A.S. Deposit date: 2000-01-20 Release date: 2000-02-02 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: Spatial Structure of the M2 Transmembrane Segment of the Nicotinic Acetylcholine Receptor Alpha-Subunit FEBS Lett., 457, 1999
1I9E	TCR DOMAIN Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYTOTOXIC TCELL VALPHA DOMAIN Authors: Rudolph, M.G, Huang, M, Teyton, L, Wilson, I.A. Deposit date: 2001-03-19 Release date: 2001-12-05 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor. J.Mol.Biol., 314, 2001
8KG5	Prefusion RSV F Bound to Lonafarnib and D25 Fab Descriptor: 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, D25 heavy chain, D25 light chain, ... Authors: Yang, Q, Xue, B, Liu, F, Peng, W, Chen, X. Deposit date: 2023-08-17 Release date: 2024-06-19 Method: ELECTRON MICROSCOPY (3.17 Å) Cite: Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein. Signal Transduct Target Ther, 9, 2024

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