Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5FUZ

Extending the half-life of a Fab fragment through generation of a humanised anti-Human Serum Albumin (HSA) Fv domain: an investigation into the correlation between affinity and serum half-life

Summary for 5FUZ
Entry DOI10.2210/pdb5fuz/pdb
Related5FUO
Descriptor645 FAB, HEAVY CHAIN, 645 FAB, LIGHT CHAIN (3 entities in total)
Functional Keywordsimmune system, anti-albumin, fab fragment, serum half-life, fcrn, human serum albumin
Biological sourceHOMO SAPIENS (HUMAN)
More
Total number of polymer chains2
Total formula weight48320.82
Authors
Adams, R.,Ceska, T. (deposition date: 2016-02-01, release date: 2016-06-29, Last modification date: 2016-11-09)
Primary citationAdams, R.,Griffin, L.,Compson, J.E.,Jairaj, M.,Baker, T.,Ceska, T.,West, S.,Zaccheo, O.,Dave, E.,Lawson, A.D.G.,Humphreys, D.P.,Heywood, S.
Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life.
Mabs, 8:1336-, 2016
Cited by
PubMed: 27315033
DOI: 10.1080/19420862.2016.1185581
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.68 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon