5FUO
Extending the half-life of a Fab fragment through generation of a humanised anti-Human Serum Albumin (HSA) Fv domain: an investigation into the correlation between affinity and serum half-life
Summary for 5FUO
Entry DOI | 10.2210/pdb5fuo/pdb |
Related | 5FUC 5FUZ |
Descriptor | SERUM ALBUMIN, FAB HEAVY CHAIN, FAB LIGHT CHAIN (3 entities in total) |
Functional Keywords | immune system, anti-albumin, fab fragment, serum half-life, fcrn, human serum albumin |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted: P02768 |
Total number of polymer chains | 3 |
Total formula weight | 114892.04 |
Authors | |
Primary citation | Adams, R.,Griffin, L.,Compson, J.E.,Jairaj, M.,Baker, T.,Ceska, T.,West, S.,Zaccheo, O.,Dave, E.,Lawson, A.D.G.,Humphreys, D.P.,Heywood, S. Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life. Mabs, 8:1336-, 2016 Cited by PubMed: 27315033DOI: 10.1080/19420862.2016.1185581 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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