5FUC

Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies

Summary for 5FUC

• Entry DOI: 10.2210/pdb5fuc/pdb
• Related: 5FUO 5FUZ
• Descriptor: INTERLEUKIN-6, INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-6 RECEPTOR, VHH6, ... (5 entities in total)
• Functional Keywords: vhh, il-6, il-6 receptor alpha, il-6 receptor beta, gp80, antibody, junctional epitope, immune system
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 6
• Total formula weight: 120150.71

Authors

Adams, R.,Griffin, R.,Doyle, C.,Ettorre, A. (deposition date: 2016-01-25, release date: 2017-01-25, Last modification date: 2024-01-10)

• Primary citation: Adams, R.,Burnley, R.J.,Valenzano, C.R.,Qureshi, O.,Doyle, C.,Lumb, S.,Del Carmen Lopez, M.,Griffin, R.,McMillan, D.,Taylor, R.D.,Meier, C.,Mori, P.,Griffin, L.M.,Wernery, U.,Kinne, J.,Rapecki, S.,Baker, T.S.,Lawson, A.D.,Wright, M.,Ettorre, A.; Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.; Sci Rep, 7:37716-37716, 2017; PubMed: 28134246; DOI: 10.1038/srep37716

Experimental method

X-RAY DIFFRACTION (2.7 Å)