5FUC
Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies
Summary for 5FUC
Entry DOI | 10.2210/pdb5fuc/pdb |
Related | 5FUO 5FUZ |
Descriptor | INTERLEUKIN-6, INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-6 RECEPTOR, VHH6, ... (5 entities in total) |
Functional Keywords | vhh, il-6, il-6 receptor alpha, il-6 receptor beta, gp80, antibody, junctional epitope, immune system |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 6 |
Total formula weight | 120150.71 |
Authors | Adams, R.,Griffin, R.,Doyle, C.,Ettorre, A. (deposition date: 2016-01-25, release date: 2017-01-25, Last modification date: 2024-01-10) |
Primary citation | Adams, R.,Burnley, R.J.,Valenzano, C.R.,Qureshi, O.,Doyle, C.,Lumb, S.,Del Carmen Lopez, M.,Griffin, R.,McMillan, D.,Taylor, R.D.,Meier, C.,Mori, P.,Griffin, L.M.,Wernery, U.,Kinne, J.,Rapecki, S.,Baker, T.S.,Lawson, A.D.,Wright, M.,Ettorre, A. Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling. Sci Rep, 7:37716-37716, 2017 Cited by PubMed: 28134246DOI: 10.1038/srep37716 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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