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5FUC

Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies

Functional Information from GO Data
ChainGOidnamespacecontents
A0001781biological_processneutrophil apoptotic process
A0002314biological_processgerminal center B cell differentiation
A0002384biological_processhepatic immune response
A0002446biological_processneutrophil mediated immunity
A0002548biological_processmonocyte chemotaxis
A0002639biological_processpositive regulation of immunoglobulin production
A0002675biological_processpositive regulation of acute inflammatory response
A0002690biological_processpositive regulation of leukocyte chemotaxis
A0005102molecular_functionsignaling receptor binding
A0005125molecular_functioncytokine activity
A0005138molecular_functioninterleukin-6 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005788cellular_componentendoplasmic reticulum lumen
A0005896cellular_componentinterleukin-6 receptor complex
A0006953biological_processacute-phase response
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0006959biological_processhumoral immune response
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0010573biological_processvascular endothelial growth factor production
A0010574biological_processregulation of vascular endothelial growth factor production
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0010628biological_processpositive regulation of gene expression
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010888biological_processnegative regulation of lipid storage
A0014823biological_processresponse to activity
A0019221biological_processcytokine-mediated signaling pathway
A0030154biological_processcell differentiation
A0030168biological_processplatelet activation
A0031018biological_processendocrine pancreas development
A0031175biological_processneuron projection development
A0032494biological_processresponse to peptidoglycan
A0032682biological_processnegative regulation of chemokine production
A0032722biological_processpositive regulation of chemokine production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032733biological_processpositive regulation of interleukin-10 production
A0032740biological_processpositive regulation of interleukin-17 production
A0032745biological_processpositive regulation of interleukin-21 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032757biological_processpositive regulation of interleukin-8 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032966biological_processnegative regulation of collagen biosynthetic process
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0035633biological_processmaintenance of blood-brain barrier
A0042102biological_processpositive regulation of T cell proliferation
A0042593biological_processglucose homeostasis
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043410biological_processpositive regulation of MAPK cascade
A0045599biological_processnegative regulation of fat cell differentiation
A0045669biological_processpositive regulation of osteoblast differentiation
A0045727biological_processpositive regulation of translation
A0045765biological_processregulation of angiogenesis
A0045779biological_processnegative regulation of bone resorption
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050768biological_processnegative regulation of neurogenesis
A0050796biological_processregulation of insulin secretion
A0050829biological_processdefense response to Gram-negative bacterium
A0050830biological_processdefense response to Gram-positive bacterium
A0050871biological_processpositive regulation of B cell activation
A0051091biological_processpositive regulation of DNA-binding transcription factor activity
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051240biological_processpositive regulation of multicellular organismal process
A0051384biological_processresponse to glucocorticoid
A0051607biological_processdefense response to virus
A0060252biological_processpositive regulation of glial cell proliferation
A0061470biological_processT follicular helper cell differentiation
A0061888biological_processregulation of astrocyte activation
A0070050biological_processneuron cellular homeostasis
A0070091biological_processglucagon secretion
A0070092biological_processregulation of glucagon secretion
A0070102biological_processinterleukin-6-mediated signaling pathway
A0070301biological_processcellular response to hydrogen peroxide
A0071222biological_processcellular response to lipopolysaccharide
A0072540biological_processT-helper 17 cell lineage commitment
A0072574biological_processhepatocyte proliferation
A0090091biological_processpositive regulation of extracellular matrix disassembly
A0090594biological_processinflammatory response to wounding
A0097421biological_processliver regeneration
A0097696biological_processcell surface receptor signaling pathway via STAT
A0098586biological_processcellular response to virus
A0150077biological_processregulation of neuroinflammatory response
A0150078biological_processpositive regulation of neuroinflammatory response
A1900017biological_processpositive regulation of cytokine production involved in inflammatory response
A1901731biological_processpositive regulation of platelet aggregation
A1902512biological_processpositive regulation of apoptotic DNA fragmentation
A1902895biological_processpositive regulation of miRNA transcription
A1903978biological_processregulation of microglial cell activation
A1904894biological_processpositive regulation of receptor signaling pathway via STAT
A1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
A2000553biological_processpositive regulation of T-helper 2 cell cytokine production
A2000635biological_processnegative regulation of primary miRNA processing
A2000660biological_processnegative regulation of interleukin-1-mediated signaling pathway
A2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
B0001781biological_processneutrophil apoptotic process
B0002314biological_processgerminal center B cell differentiation
B0002384biological_processhepatic immune response
B0002446biological_processneutrophil mediated immunity
B0002548biological_processmonocyte chemotaxis
B0002639biological_processpositive regulation of immunoglobulin production
B0002675biological_processpositive regulation of acute inflammatory response
B0002690biological_processpositive regulation of leukocyte chemotaxis
B0005102molecular_functionsignaling receptor binding
B0005125molecular_functioncytokine activity
B0005138molecular_functioninterleukin-6 receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005788cellular_componentendoplasmic reticulum lumen
B0005896cellular_componentinterleukin-6 receptor complex
B0006953biological_processacute-phase response
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0006959biological_processhumoral immune response
B0007259biological_processcell surface receptor signaling pathway via JAK-STAT
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0010573biological_processvascular endothelial growth factor production
B0010574biological_processregulation of vascular endothelial growth factor production
B0010575biological_processpositive regulation of vascular endothelial growth factor production
B0010628biological_processpositive regulation of gene expression
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010888biological_processnegative regulation of lipid storage
B0014823biological_processresponse to activity
B0019221biological_processcytokine-mediated signaling pathway
B0030154biological_processcell differentiation
B0030168biological_processplatelet activation
B0031018biological_processendocrine pancreas development
B0031175biological_processneuron projection development
B0032494biological_processresponse to peptidoglycan
B0032682biological_processnegative regulation of chemokine production
B0032722biological_processpositive regulation of chemokine production
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032733biological_processpositive regulation of interleukin-10 production
B0032740biological_processpositive regulation of interleukin-17 production
B0032745biological_processpositive regulation of interleukin-21 production
B0032755biological_processpositive regulation of interleukin-6 production
B0032757biological_processpositive regulation of interleukin-8 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032966biological_processnegative regulation of collagen biosynthetic process
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0035633biological_processmaintenance of blood-brain barrier
B0042102biological_processpositive regulation of T cell proliferation
B0042593biological_processglucose homeostasis
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043410biological_processpositive regulation of MAPK cascade
B0045599biological_processnegative regulation of fat cell differentiation
B0045669biological_processpositive regulation of osteoblast differentiation
B0045727biological_processpositive regulation of translation
B0045765biological_processregulation of angiogenesis
B0045779biological_processnegative regulation of bone resorption
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050768biological_processnegative regulation of neurogenesis
B0050796biological_processregulation of insulin secretion
B0050829biological_processdefense response to Gram-negative bacterium
B0050830biological_processdefense response to Gram-positive bacterium
B0050871biological_processpositive regulation of B cell activation
B0051091biological_processpositive regulation of DNA-binding transcription factor activity
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0051240biological_processpositive regulation of multicellular organismal process
B0051384biological_processresponse to glucocorticoid
B0051607biological_processdefense response to virus
B0060252biological_processpositive regulation of glial cell proliferation
B0061470biological_processT follicular helper cell differentiation
B0061888biological_processregulation of astrocyte activation
B0070050biological_processneuron cellular homeostasis
B0070091biological_processglucagon secretion
B0070092biological_processregulation of glucagon secretion
B0070102biological_processinterleukin-6-mediated signaling pathway
B0070301biological_processcellular response to hydrogen peroxide
B0071222biological_processcellular response to lipopolysaccharide
B0072540biological_processT-helper 17 cell lineage commitment
B0072574biological_processhepatocyte proliferation
B0090091biological_processpositive regulation of extracellular matrix disassembly
B0090594biological_processinflammatory response to wounding
B0097421biological_processliver regeneration
B0097696biological_processcell surface receptor signaling pathway via STAT
B0098586biological_processcellular response to virus
B0150077biological_processregulation of neuroinflammatory response
B0150078biological_processpositive regulation of neuroinflammatory response
B1900017biological_processpositive regulation of cytokine production involved in inflammatory response
B1901731biological_processpositive regulation of platelet aggregation
B1902512biological_processpositive regulation of apoptotic DNA fragmentation
B1902895biological_processpositive regulation of miRNA transcription
B1903978biological_processregulation of microglial cell activation
B1904894biological_processpositive regulation of receptor signaling pathway via STAT
B1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
B2000553biological_processpositive regulation of T-helper 2 cell cytokine production
B2000635biological_processnegative regulation of primary miRNA processing
B2000660biological_processnegative regulation of interleukin-1-mediated signaling pathway
B2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
C0004896molecular_functioncytokine receptor activity
C0016020cellular_componentmembrane
D0004896molecular_functioncytokine receptor activity
D0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00254
Number of Residues26
DetailsINTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CfqsgfneetClvkiitGLleFevyL
ChainResidueDetails
ACYS73-LEU98

site_idPS01354
Number of Residues42
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LqPDPPanItvtavarnprwLsvtWqdPhSWnssf..YrLrFeL
ChainResidueDetails
CLEU195-LEU236

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Not glycosylated => ECO:0000269|PubMed:10066782
ChainResidueDetails
CASN226
DASN226

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10066782, ECO:0000269|PubMed:28060820
ChainResidueDetails
CASN202
DASN202

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28060820
ChainResidueDetails
CASN226
DASN226

226707

PDB entries from 2024-10-30

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