3CUI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3cui by Molmil](/molmil-images/mine/3cui) | |
4PXX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pxx by Molmil](/molmil-images/mine/4pxx) | |
3D7M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3d7m by Molmil](/molmil-images/mine/3d7m) | Crystal Structure of the G Protein Fast-Exchange Double Mutant I56C/Q333C | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | Authors: | Funk, M.A, Preininger, A.M, Oldham, W.M, Meier, S.M, Hamm, H.E, Iverson, T.M. | Deposit date: | 2008-05-21 | Release date: | 2009-03-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. Biochemistry, 48, 2009
|
|
4Q7U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q7u by Molmil](/molmil-images/mine/4q7u) | |
3VF3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3vf3 by Molmil](/molmil-images/mine/3vf3) | Crystal Structure of Human Beta Secretase in Complex with NVP-BQQ711 | Descriptor: | (3S,4S,5R)-3-(4-amino-3-bromo-5-fluorobenzyl)-5-{[3-(1,1-difluoroethyl)benzyl]amino}tetrahydro-2H-thiopyran-4-ol 1,1-dioxide, Beta-secretase 1 | Authors: | Rondeau, J.M, Bourgier, E. | Deposit date: | 2012-01-09 | Release date: | 2012-11-21 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides J.Med.Chem., 55, 2012
|
|
4PYZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pyz by Molmil](/molmil-images/mine/4pyz) | Crystal structure of the first two Ubl domains of Deubiquitylase USP7 | Descriptor: | UNKNOWN ATOM OR ION, Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Walker, J.R, Dong, A, Ong, M.S, Dhe-Paganon, S, Kania, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | Deposit date: | 2014-03-28 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Crystal structure of the first two Ubl domains of Deubiquitylase USP7 to be published
|
|
3VG1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3vg1 by Molmil](/molmil-images/mine/3vg1) | Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a soaking experiment | Descriptor: | (3R,4S,5S)-3-[(3-tert-butylbenzyl)amino]-5-{[3-(2,2-difluoroethyl)-1H-indol-5-yl]methyl}tetrahydro-2H-thiopyran-4-ol 1,1-dioxide, Beta-secretase 1 | Authors: | Rondeau, J.M, Bourgier, E. | Deposit date: | 2012-01-10 | Release date: | 2012-11-21 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides J.Med.Chem., 55, 2012
|
|
4PZG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pzg by Molmil](/molmil-images/mine/4pzg) | Crystal structure of human sorting nexin 10 (SNX10) | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, NITRATE ION, Sorting nexin-10 | Authors: | Xu, T, Xu, J, Wang, Q, Liu, J. | Deposit date: | 2014-03-30 | Release date: | 2014-09-24 | Last modified: | 2014-12-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins, 82, 2014
|
|
3D0S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3d0s by Molmil](/molmil-images/mine/3d0s) | |
3VGL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3vgl by Molmil](/molmil-images/mine/3vgl) | Crystal structure of a ROK family glucokinase from Streptomyces griseus in complex with glucose and AMPPNP | Descriptor: | Glucokinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ... | Authors: | Miyazono, K, Tabei, N, Morita, S, Ohnishi, Y, Horinouchi, S, Tanokura, M. | Deposit date: | 2011-08-15 | Release date: | 2011-12-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Substrate recognition mechanism and substrate-dependent conformational changes of an ROK family glucokinase from Streptomyces griseus J.Bacteriol., 194, 2012
|
|
3VVS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3vvs by Molmil](/molmil-images/mine/3vvs) | Crystal structure of MATE in complex with MaD3S | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Putative uncharacterized protein, macrocyclic peptide | Authors: | Tanaka, Y, Ishitani, R, Nureki, O. | Deposit date: | 2012-07-27 | Release date: | 2013-04-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
|
|
3CIP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3cip by Molmil](/molmil-images/mine/3cip) | Complex of Dictyostelium Discoideum Actin with Gelsolin | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, GLYCEROL, ... | Authors: | Baek, K, Dominguez, R. | Deposit date: | 2008-03-11 | Release date: | 2008-08-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding. Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
3D1F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3d1f by Molmil](/molmil-images/mine/3d1f) | Crystal structure of E. coli sliding clamp (beta) bound to a polymerase III peptide | Descriptor: | 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, DI(HYDROXYETHYL)ETHER, DNA polymerase III subunit beta, ... | Authors: | Georgescu, R.E, Yurieva, O, Seung-Sup, K, Kuriyan, J, Kong, X.-P, O'Donnell, M. | Deposit date: | 2008-05-05 | Release date: | 2008-07-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp. Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
3VW7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3vw7 by Molmil](/molmil-images/mine/3vw7) | Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, Proteinase-activated receptor 1, ... | Authors: | Zhang, C, Srinivasan, Y, Arlow, D.H, Fung, J.J, Palmer, D, Zheng, Y, Green, H.F, Pandey, A, Dror, R.O, Shaw, D.E, Weis, W.I, Coughlin, S.R, Kobilka, B.K. | Deposit date: | 2012-08-07 | Release date: | 2012-12-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | High-resolution crystal structure of human protease-activated receptor 1 Nature, 492, 2012
|
|
3D2F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3d2f by Molmil](/molmil-images/mine/3d2f) | Crystal structure of a complex of Sse1p and Hsp70 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Heat shock 70 kDa protein 1, ... | Authors: | Polier, S, Bracher, A. | Deposit date: | 2008-05-08 | Release date: | 2008-06-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding. Cell(Cambridge,Mass.), 133, 2008
|
|
3CKH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ckh by Molmil](/molmil-images/mine/3ckh) | Crystal structure of Eph A4 receptor | Descriptor: | Ephrin type-A receptor 4 | Authors: | Shi, J.H, Song, J.X. | Deposit date: | 2008-03-15 | Release date: | 2008-09-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor. J.Biol.Chem., 283, 2008
|
|
3D4D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3d4d by Molmil](/molmil-images/mine/3d4d) | |
4QIY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qiy by Molmil](/molmil-images/mine/4qiy) | Crystal structure of human carbonic anhydrase isozyme II with inhibitor | Descriptor: | 2,3,6-trifluoro-5-{[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino}-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... | Authors: | Manakova, E, Smirnov, A, Grazulis, S. | Deposit date: | 2014-06-03 | Release date: | 2015-04-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Functionalization of Fluorinated Benzenesulfonamides and Their Inhibitory Properties toward Carbonic Anhydrases Chemmedchem, 10, 2015
|
|
4QJI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qji by Molmil](/molmil-images/mine/4qji) | |
4QJR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qjr by Molmil](/molmil-images/mine/4qjr) | Crystal structure of human nuclear receptor sf-1 (nr5a1) bound to its hormone pip3 at 2.4 a resolution | Descriptor: | (2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dihexadecanoate, ACETATE ION, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ... | Authors: | Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL) | Deposit date: | 2014-06-04 | Release date: | 2014-07-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4QKS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qks by Molmil](/molmil-images/mine/4qks) | Crystal Structure of 6xTrp/PV2: de novo designed beta-trefoil architecture with symmetric primary structure (L22W/L44W/L64W/L85W/L108W/L132W his Primitive Version 2) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DE NOVO PROTEIN 6XTRP/PV2, SULFATE ION | Authors: | Longo, L.M, Tenorio, C.A, Blaber, M. | Deposit date: | 2014-06-09 | Release date: | 2015-01-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A single aromatic core mutation converts a designed "primitive" protein from halophile to mesophile folding. Protein Sci., 24, 2015
|
|
3VMK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3vmk by Molmil](/molmil-images/mine/3vmk) | 3-isopropylmalate dehydrogenase from Shewanella benthica DB21 MT-2 | Descriptor: | 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, CHLORIDE ION, ... | Authors: | Nagae, T, Watanabe, N. | Deposit date: | 2011-12-13 | Release date: | 2012-02-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Structural analysis of 3-isopropylmalate dehydrogenase from the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1 Acta Crystallogr.,Sect.F, 68, 2012
|
|
4QOM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qom by Molmil](/molmil-images/mine/4qom) | Bacillus pumilus catalase with pyrogallol bound | Descriptor: | BENZENE-1,2,3-TRIOL, CHLORIDE ION, Catalase, ... | Authors: | Loewen, P.C. | Deposit date: | 2014-06-20 | Release date: | 2015-02-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Unprecedented access of phenolic substrates to the heme active site of a catalase: Substrate binding and peroxidase-like reactivity of Bacillus pumilus catalase monitored by X-ray crystallography and EPR spectroscopy. Proteins, 83, 2015
|
|
4QGG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qgg by Molmil](/molmil-images/mine/4qgg) | |
3CGI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3cgi by Molmil](/molmil-images/mine/3cgi) | |