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4P0L
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Crystal Structure of Double Loop-Swapped Interleukin-36Ra With Additional Point Mutations
Descriptor: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein
Authors:Guenther, S, Sundberg, E.J.
Deposit date:2014-02-21
Release date:2014-06-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor.
J Immunol., 193, 2014
4P0K
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BU of 4p0k by Molmil
Crystal Structure of Double Loop-Swapped Interleukin-36Ra
Descriptor: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein
Authors:Guenther, S, Sundberg, E.J.
Deposit date:2014-02-21
Release date:2014-06-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor.
J Immunol., 193, 2014
4P0J
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BU of 4p0j by Molmil
Crystal Structure of Loop-Swapped Interleukin-36Ra
Descriptor: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein
Authors:Guenther, S, Sundberg, E.J.
Deposit date:2014-02-21
Release date:2014-06-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor.
J Immunol., 193, 2014
4R6U
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BU of 4r6u by Molmil
IL-18 receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-18, Interleukin-18 receptor 1
Authors:Wei, H, Wang, X.
Deposit date:2014-08-26
Release date:2014-10-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the specific recognition of IL-18 by its alpha receptor.
Febs Lett., 588, 2014
3WO2
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Crystal structure of human interleukin-18
Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Interleukin-18, SULFATE ION
Authors:Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H.
Deposit date:2013-12-19
Release date:2014-12-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
3WO4
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Crystal structure of the IL-18 signaling ternary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H.
Deposit date:2013-12-19
Release date:2014-12-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
3WO3
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BU of 3wo3 by Molmil
Crystal structure of IL-18 in complex with IL-18 receptor alpha
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H.
Deposit date:2013-12-19
Release date:2014-12-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
4XFT
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BU of 4xft by Molmil
Structure of IL-18 SER Mutant III
Descriptor: DIMETHYL SULFOXIDE, Interleukin-18
Authors:Krumm, B.E, Meng, X, Xiang, Y, Deng, J.
Deposit date:2014-12-29
Release date:2015-06-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallization of interleukin-18 for structure-based inhibitor design.
Acta Crystallogr.,Sect.F, 71, 2015
4XFS
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BU of 4xfs by Molmil
Structure of IL-18 SER Mutant I
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Interleukin-18
Authors:Krumm, B.E, Meng, X, Xiang, Y, Deng, J.
Deposit date:2014-12-28
Release date:2015-06-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystallization of interleukin-18 for structure-based inhibitor design.
Acta Crystallogr.,Sect.F, 71, 2015
4XFU
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BU of 4xfu by Molmil
Structure of IL-18 SER Mutant V
Descriptor: Interleukin-18
Authors:Krumm, B.E, Meng, X, Xiang, Y, Deng, J.
Deposit date:2014-12-29
Release date:2015-06-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystallization of interleukin-18 for structure-based inhibitor design.
Acta Crystallogr.,Sect.F, 71, 2015
5BVP
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BU of 5bvp by Molmil
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta
Descriptor: CHLORIDE ION, Canakinumab Fab light-chain, Interleukin-1 beta, ...
Authors:Rondeau, J.M.
Deposit date:2015-06-05
Release date:2015-09-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1 beta.
Mabs, 7, 2015
4X3A
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BU of 4x3a by Molmil
gallus interleukin-1 beta mutant - R140A
Descriptor: IL-1 beta
Authors:Yin, H.S, Cheng, W.T.
Deposit date:2014-11-28
Release date:2015-12-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:gallus interleukin-1 beta mutant - R140A
To Be Published
4X37
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BU of 4x37 by Molmil
Gallus interleukin-1 mutant - E118K
Descriptor: IL-1 beta
Authors:Yin, H.S, Cheng, W.T, Cheng, T.
Deposit date:2014-11-28
Release date:2015-12-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Gallus interleukin-1 mutant - E118K
To Be Published
4X39
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BU of 4x39 by Molmil
Gallus interleukin-1 beta mutant - T117A
Descriptor: IL-1 beta
Authors:Yin, H.S, Cheng, W.T.
Deposit date:2014-11-28
Release date:2015-12-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Gallus interleukin-1 beta mutant - T117A
To Be Published
4X38
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BU of 4x38 by Molmil
Gallus interleukin-1 beta mutant - E118A
Descriptor: IL-1 beta
Authors:Yin, H.S, Cheng, W.T.
Deposit date:2014-11-28
Release date:2015-12-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Gallus interleukin-1 beta mutant - E118A
To Be Published
5BOW
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BU of 5bow by Molmil
CRYSTAL STRUCTURE OF IL-38
Descriptor: 1,2-ETHANEDIOL, Interleukin-1 family member 10
Authors:Guenther, S, Sundberg, E.J.
Deposit date:2015-05-27
Release date:2016-06-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Crystal Structure of Interleukin-38
To Be Published
5MVZ
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BU of 5mvz by Molmil
Fab 4AB007 bound to Interleukin-1-beta
Descriptor: Fab 4AB007 H-chain, Fab 4AB007 L-chain, GLYCEROL, ...
Authors:Stark, W, Seibert, V.
Deposit date:2017-01-17
Release date:2017-02-15
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of a novel, fully Human Fab binding to Interleukin 1-beta.
To Be Published
5HN1
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BU of 5hn1 by Molmil
Crystal structure of Interleukin-37
Descriptor: Interleukin-37, SULFATE ION
Authors:Ellisdon, A.M, Nold-Petry, C.A, Nold, M.F, Whisstock, J.C.
Deposit date:2016-01-17
Release date:2017-02-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Homodimerization attenuates the anti-inflammatory activity of interleukin-37.
Sci Immunol, 2, 2017
5UC6
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BU of 5uc6 by Molmil
Structural insights into IL-1 alpha recognition by a naphthyl-modified aptamer that mimics IL-1RI Domain III
Descriptor: DNA (5'-D(*CP*G)-R(P*(85Y))-D(P*GP*AP*G)-R(P*(85Y)P*(85Y))-D(P*A)-R(P*(85Y))-D(P*GP*GP*G)-R(P*(85Y)P*(85Y))-D(P*AP*GP*AP*G)-R(P*(85Y))-D(P*CP*GP*(ATD))-3'), Interleukin-1 alpha, MAGNESIUM ION, ...
Authors:Ren, X, Pyle, A.
Deposit date:2016-12-21
Release date:2017-10-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for IL-1 alpha recognition by a modified DNA aptamer that specifically inhibits IL-1 alpha signaling.
Nat Commun, 8, 2017
6NCU
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BU of 6ncu by Molmil
Interleukin-37 residues 53-206- dimer
Descriptor: Interleukin-37
Authors:Eisenmesser, E.Z.
Deposit date:2018-12-12
Release date:2019-03-13
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Interleukin-37 monomer is the active form for reducing innate immunity.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6P9E
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BU of 6p9e by Molmil
Crystal structure of IL-36gamma complexed to A-552
Descriptor: (2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic acid, Interleukin-36 gamma
Authors:Argiriadi, M.A, Todorovic, T, Su, Z, Putman, B, Kakavas, S.J, Salte, K.M, McDonald, H.A, Wetter, J.B, Paulsboe, S.E, Sun, Q, Gerstein, C.E, Medina, L, Sielaff, B, Sadhukhan, R, Stockmann, H, Richardson, P.L, Qiu, W, Henry, R.F, Herold, J.M, Shotwell, J.B, McGaraughty, S.P, Honore, P, Gopalakrishnan, S.M, Sun, C.C, Scott, V.E.
Deposit date:2019-06-10
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis.
Sci Rep, 9, 2019
6HPI
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BU of 6hpi by Molmil
NMR structure of the pro-inflammatory cytokine interleukin-36alpha
Descriptor: Interleukin-36 alpha
Authors:Ohlenschlaeger, O, Imhof, D.
Deposit date:2018-09-21
Release date:2019-10-02
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:(1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36alpha.
Biomol NMR Assign, 10, 2016
6Y8M
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BU of 6y8m by Molmil
Fragment bikinin bound to Interleukin 1 beta
Descriptor: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid, Interleukin-1 beta, SULFATE ION
Authors:De Nicola, G.F, Nichols, C.E.
Deposit date:2020-03-05
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Fragment bikinin bound to Interleukin 1 beta
To Be Published
5R88
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BU of 5r88 by Molmil
PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z1545313172 in complex with INTERLEUKIN-1 BETA
Descriptor: (2~{S})-~{N}-(4-aminocarbonylphenyl)oxolane-2-carboxamide, Interleukin-1 beta, SULFATE ION
Authors:De Nicola, G.F, Nichols, C.E.
Deposit date:2020-03-03
Release date:2020-04-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
J.Med.Chem., 63, 2020
5R8P
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BU of 5r8p by Molmil
PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z818727262 in complex with INTERLEUKIN-1 BETA
Descriptor: Interleukin-1 beta, SULFATE ION, ~{N}-[[(3~{S})-oxolan-3-yl]methyl]cyclopropanamine
Authors:De Nicola, G.F, Nichols, C.E.
Deposit date:2020-03-03
Release date:2020-04-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
J.Med.Chem., 63, 2020

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