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4P0L	Crystal Structure of Double Loop-Swapped Interleukin-36Ra With Additional Point Mutations Descriptor: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein Authors: Guenther, S, Sundberg, E.J. Deposit date: 2014-02-21 Release date: 2014-06-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J Immunol., 193, 2014
4P0K	Crystal Structure of Double Loop-Swapped Interleukin-36Ra Descriptor: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein Authors: Guenther, S, Sundberg, E.J. Deposit date: 2014-02-21 Release date: 2014-06-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J Immunol., 193, 2014
4P0J	Crystal Structure of Loop-Swapped Interleukin-36Ra Descriptor: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein Authors: Guenther, S, Sundberg, E.J. Deposit date: 2014-02-21 Release date: 2014-06-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.298 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J Immunol., 193, 2014
4R6U	IL-18 receptor complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-18, Interleukin-18 receptor 1 Authors: Wei, H, Wang, X. Deposit date: 2014-08-26 Release date: 2014-10-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for the specific recognition of IL-18 by its alpha receptor. Febs Lett., 588, 2014
3WO2	Crystal structure of human interleukin-18 Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Interleukin-18, SULFATE ION Authors: Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. Deposit date: 2013-12-19 Release date: 2014-12-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.33 Å) Cite: The structural basis for receptor recognition of human interleukin-18 Nat Commun, 5, 2014
3WO4	Crystal structure of the IL-18 signaling ternary complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. Deposit date: 2013-12-19 Release date: 2014-12-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.1 Å) Cite: The structural basis for receptor recognition of human interleukin-18 Nat Commun, 5, 2014
3WO3	Crystal structure of IL-18 in complex with IL-18 receptor alpha Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. Deposit date: 2013-12-19 Release date: 2014-12-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.1 Å) Cite: The structural basis for receptor recognition of human interleukin-18 Nat Commun, 5, 2014
4XFT	Structure of IL-18 SER Mutant III Descriptor: DIMETHYL SULFOXIDE, Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-29 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4XFS	Structure of IL-18 SER Mutant I Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-28 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4XFU	Structure of IL-18 SER Mutant V Descriptor: Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-29 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
5BVP	The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta Descriptor: CHLORIDE ION, Canakinumab Fab light-chain, Interleukin-1 beta, ... Authors: Rondeau, J.M. Deposit date: 2015-06-05 Release date: 2015-09-02 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1 beta. Mabs, 7, 2015
4X3A	gallus interleukin-1 beta mutant - R140A Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.75 Å) Cite: gallus interleukin-1 beta mutant - R140A To Be Published
4X37	Gallus interleukin-1 mutant - E118K Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T, Cheng, T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Gallus interleukin-1 mutant - E118K To Be Published
4X39	Gallus interleukin-1 beta mutant - T117A Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Gallus interleukin-1 beta mutant - T117A To Be Published
4X38	Gallus interleukin-1 beta mutant - E118A Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Gallus interleukin-1 beta mutant - E118A To Be Published
5BOW	CRYSTAL STRUCTURE OF IL-38 Descriptor: 1,2-ETHANEDIOL, Interleukin-1 family member 10 Authors: Guenther, S, Sundberg, E.J. Deposit date: 2015-05-27 Release date: 2016-06-01 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Crystal Structure of Interleukin-38 To Be Published
5MVZ	Fab 4AB007 bound to Interleukin-1-beta Descriptor: Fab 4AB007 H-chain, Fab 4AB007 L-chain, GLYCEROL, ... Authors: Stark, W, Seibert, V. Deposit date: 2017-01-17 Release date: 2017-02-15 Last modified: 2019-02-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure of a novel, fully Human Fab binding to Interleukin 1-beta. To Be Published
5HN1	Crystal structure of Interleukin-37 Descriptor: Interleukin-37, SULFATE ION Authors: Ellisdon, A.M, Nold-Petry, C.A, Nold, M.F, Whisstock, J.C. Deposit date: 2016-01-17 Release date: 2017-02-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Homodimerization attenuates the anti-inflammatory activity of interleukin-37. Sci Immunol, 2, 2017
5UC6	Structural insights into IL-1 alpha recognition by a naphthyl-modified aptamer that mimics IL-1RI Domain III Descriptor: DNA (5'-D(*CP*G)-R(P*(85Y))-D(P*GP*AP*G)-R(P*(85Y)P*(85Y))-D(P*A)-R(P*(85Y))-D(P*GP*GP*G)-R(P*(85Y)P*(85Y))-D(P*AP*GP*AP*G)-R(P*(85Y))-D(P*CP*GP*(ATD))-3'), Interleukin-1 alpha, MAGNESIUM ION, ... Authors: Ren, X, Pyle, A. Deposit date: 2016-12-21 Release date: 2017-10-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for IL-1 alpha recognition by a modified DNA aptamer that specifically inhibits IL-1 alpha signaling. Nat Commun, 8, 2017
6NCU	Interleukin-37 residues 53-206- dimer Descriptor: Interleukin-37 Authors: Eisenmesser, E.Z. Deposit date: 2018-12-12 Release date: 2019-03-13 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Interleukin-37 monomer is the active form for reducing innate immunity. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6P9E	Crystal structure of IL-36gamma complexed to A-552 Descriptor: (2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic acid, Interleukin-36 gamma Authors: Argiriadi, M.A, Todorovic, T, Su, Z, Putman, B, Kakavas, S.J, Salte, K.M, McDonald, H.A, Wetter, J.B, Paulsboe, S.E, Sun, Q, Gerstein, C.E, Medina, L, Sielaff, B, Sadhukhan, R, Stockmann, H, Richardson, P.L, Qiu, W, Henry, R.F, Herold, J.M, Shotwell, J.B, McGaraughty, S.P, Honore, P, Gopalakrishnan, S.M, Sun, C.C, Scott, V.E. Deposit date: 2019-06-10 Release date: 2019-06-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis. Sci Rep, 9, 2019
6HPI	NMR structure of the pro-inflammatory cytokine interleukin-36alpha Descriptor: Interleukin-36 alpha Authors: Ohlenschlaeger, O, Imhof, D. Deposit date: 2018-09-21 Release date: 2019-10-02 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: (1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36alpha. Biomol NMR Assign, 10, 2016
6Y8M	Fragment bikinin bound to Interleukin 1 beta Descriptor: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-05 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment bikinin bound to Interleukin 1 beta To Be Published
5R88	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z1545313172 in complex with INTERLEUKIN-1 BETA Descriptor: (2~{S})-~{N}-(4-aminocarbonylphenyl)oxolane-2-carboxamide, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R8P	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z818727262 in complex with INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, SULFATE ION, ~{N}-[[(3~{S})-oxolan-3-yl]methyl]cyclopropanamine Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020

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