2FKY
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![BU of 2fky by Molmil](/molmil-images/mine/2fky) | crystal structure of KSP in complex with inhibitor 13 | Descriptor: | (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Yan, Y. | Deposit date: | 2006-01-05 | Release date: | 2006-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. Bioorg.Med.Chem.Lett., 16, 2006
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1II6
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![BU of 1ii6 by Molmil](/molmil-images/mine/1ii6) | Crystal Structure of the Mitotic Kinesin Eg5 in Complex with Mg-ADP. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-RELATED MOTOR PROTEIN Eg5, MAGNESIUM ION, ... | Authors: | Turner, J, Anderson, R, Guo, J, Beraud, C, Sakowicz, R, Fletterick, R. | Deposit date: | 2001-04-20 | Release date: | 2001-07-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker. J.Biol.Chem., 276, 2001
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3DCB
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![BU of 3dcb by Molmil](/molmil-images/mine/3dcb) | Crystal structure of the Drosophila kinesin family member NOD in complex with AMPPNP | Descriptor: | Kinesin-like protein Nod, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Cochran, J.C, Mulko, N.K, Kull, F.J. | Deposit date: | 2008-06-03 | Release date: | 2009-02-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement. Cell(Cambridge,Mass.), 136, 2009
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1MKJ
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![BU of 1mkj by Molmil](/molmil-images/mine/1mkj) | Human Kinesin Motor Domain With Docked Neck Linker | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN HEAVY CHAIN, MAGNESIUM ION, ... | Authors: | Sindelar, C.V, Budny, M.J, Rice, S, Naber, N, Fletterick, R, Cooke, R. | Deposit date: | 2002-08-29 | Release date: | 2002-10-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy. Nat.Struct.Biol., 9, 2002
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2FL2
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![BU of 2fl2 by Molmil](/molmil-images/mine/2fl2) | crystal structure of KSP in complex with inhibitor 19 | Descriptor: | (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Yan, Y. | Deposit date: | 2006-01-05 | Release date: | 2006-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. Bioorg.Med.Chem.Lett., 16, 2006
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2FL6
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![BU of 2fl6 by Molmil](/molmil-images/mine/2fl6) | crystal structure of KSP in complex with inhibitor 6 | Descriptor: | (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Yan, Y. | Deposit date: | 2006-01-05 | Release date: | 2006-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. Bioorg.Med.Chem.Lett., 16, 2006
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2G1Q
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![BU of 2g1q by Molmil](/molmil-images/mine/2g1q) | crystal structure of KSP in complex with inhibitor 9h | Descriptor: | (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Yan, Y. | Deposit date: | 2006-02-14 | Release date: | 2006-10-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP. Bioorg.Med.Chem.Lett., 16, 2006
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6TRL
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![BU of 6trl by Molmil](/molmil-images/mine/6trl) | Human Eg5 motor domain mutant Y82F | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, Kinesin-like protein KIF11, ... | Authors: | Garcia-Saez, I, Skoufias, D.A. | Deposit date: | 2019-12-19 | Release date: | 2021-06-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Human Eg5 motor domain mutant Y82F To Be Published
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6TLE
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![BU of 6tle by Molmil](/molmil-images/mine/6tle) | Human Eg5 motor domain mutant E344K | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ... | Authors: | Garcia-Saez, I, Skoufias, D.A. | Deposit date: | 2019-12-02 | Release date: | 2021-06-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Human Eg5 motor domain mutant E344K To Be Published
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2OWM
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![BU of 2owm by Molmil](/molmil-images/mine/2owm) | Motor domain of Neurospora crassa kinesin-3 (NcKin3) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Related to KINESIN-LIKE PROTEIN KIF1C | Authors: | Marx, A, Muller, J, Mandelkow, E.-M, Woehlke, G, Mandelkow, E. | Deposit date: | 2007-02-16 | Release date: | 2008-01-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | X-ray Structure and Microtubule Interaction of the Motor Domain of Neurospora crassa NcKin3, a Kinesin with Unusual Processivity Biochemistry, 47, 2008
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2PG2
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![BU of 2pg2 by Molmil](/molmil-images/mine/2pg2) | |
2Q2Z
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![BU of 2q2z by Molmil](/molmil-images/mine/2q2z) | Crystal Structure of KSP in Complex with Inhibitor 22 | Descriptor: | 1-[(4R)-4-[3-(4-ACETYLPIPERAZIN-1-YL)PROPYL]-1-(2-FLUORO-5-METHYLPHENYL)-4-PHENYL-4,5-DIHYDRO-1H-PYRAZOL-3-YL]ETHANONE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Yan, Y. | Deposit date: | 2007-05-29 | Release date: | 2007-09-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Bioorg.Med.Chem.Lett., 17, 2007
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2Q2Y
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![BU of 2q2y by Molmil](/molmil-images/mine/2q2y) | Crystal Structure of KSP in complex with Inhibitor 1 | Descriptor: | 1-{(3R,3AR)-3-[3-(4-ACETYLPIPERAZIN-1-YL)PROPYL]-8-FLUORO-3-PHENYL-3A,4-DIHYDRO-3H-PYRAZOLO[5,1-C][1,4]BENZOXAZIN-2-YL}ETHANONE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Yan, Y. | Deposit date: | 2007-05-29 | Release date: | 2007-09-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Bioorg.Med.Chem.Lett., 17, 2007
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2NCD
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![BU of 2ncd by Molmil](/molmil-images/mine/2ncd) | NCD (NON-CLARET DISJUNCTIONAL) DIMER FROM D. MELANOGASTER | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PROTEIN (Kinesin motor NCD), SULFATE ION | Authors: | Sablin, E.P, Case, R.B, Dai, S.C, Hart, C.L, Ruby, A, Vale, R.D, Fletterick, R.J. | Deposit date: | 1999-06-04 | Release date: | 1999-06-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Direction determination in the minus-end-directed kinesin motor ncd. Nature, 395, 1998
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2IEH
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![BU of 2ieh by Molmil](/molmil-images/mine/2ieh) | |
2KIN
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![BU of 2kin by Molmil](/molmil-images/mine/2kin) | KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN, SULFATE ION | Authors: | Sack, S, Muller, J, Kozielski, F, Marx, A, Thormahlen, M, Biou, V, Mandelkow, E.-M, Brady, S.T, Mandelkow, E. | Deposit date: | 1997-04-28 | Release date: | 1998-04-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry, 36, 1997
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2HEH
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![BU of 2heh by Molmil](/molmil-images/mine/2heh) | Crystal Structure of the KIF2C motor domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KIF2C protein, MAGNESIUM ION, ... | Authors: | Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2006-06-21 | Release date: | 2006-07-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of the kif2c motor domain to be published
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2GM1
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![BU of 2gm1 by Molmil](/molmil-images/mine/2gm1) | Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-RELATED MOTOR PROTEIN EG5, MAGNESIUM ION, ... | Authors: | Sheriff, S. | Deposit date: | 2006-04-05 | Release date: | 2006-06-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
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2GRY
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![BU of 2gry by Molmil](/molmil-images/mine/2gry) | Crystal structure of the human KIF2 motor domain in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF2, MAGNESIUM ION, ... | Authors: | Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2006-04-25 | Release date: | 2006-05-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of the human KIF2 motor domain in complex with ADP to be published
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1SDM
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![BU of 1sdm by Molmil](/molmil-images/mine/1sdm) | Crystal structure of kinesin-like calmodulin binding protein | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, kinesin heavy chain-like protein | Authors: | Vinogradova, M.V, Reddy, V.S, Reddy, A.S, Sablin, E.P, Fletterick, R.J. | Deposit date: | 2004-02-13 | Release date: | 2004-06-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of kinesin regulated by Ca(2+)-calmodulin. J.Biol.Chem., 279, 2004
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1RY6
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![BU of 1ry6 by Molmil](/molmil-images/mine/1ry6) | Crystal Structure of Internal Kinesin Motor Domain | Descriptor: | INTERNAL KINESIN, SULFATE ION | Authors: | Shipley, K, Hekmat-Nejad, M, Turner, J, Moores, C, Anderson, R, Milligan, R, Sakowicz, R, Fletterick, R. | Deposit date: | 2003-12-19 | Release date: | 2004-04-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of a kinesin microtubule depolymerization machine. Embo J., 23, 2004
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1V8J
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![BU of 1v8j by Molmil](/molmil-images/mine/1v8j) | The Crystal Structure of the Minimal Functional Domain of the Microtubule Destabilizer KIF2C Complexed with Mg-ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF2C, MAGNESIUM ION | Authors: | Ogawa, T, Nitta, R, Okada, Y, Hirokawa, N. | Deposit date: | 2004-01-09 | Release date: | 2004-03-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops. Cell(Cambridge,Mass.), 116, 2004
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1V8K
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![BU of 1v8k by Molmil](/molmil-images/mine/1v8k) | The Crystal Structure of the Minimal Functional Domain of the Microtubule Destabilizer KIF2C Complexed with Mg-AMPPNP | Descriptor: | Kinesin-like protein KIF2C, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Ogawa, T, Nitta, R, Okada, Y, Hirokawa, N. | Deposit date: | 2004-01-09 | Release date: | 2004-03-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops. Cell(Cambridge,Mass.), 116, 2004
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1T5C
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![BU of 1t5c by Molmil](/molmil-images/mine/1t5c) | Crystal structure of the motor domain of human kinetochore protein CENP-E | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Centromeric protein E, MAGNESIUM ION, ... | Authors: | Garcia-Saez, I, Yen, T, Wade, R.H, Kozielski, F, Structural Proteomics in Europe (SPINE) | Deposit date: | 2004-05-04 | Release date: | 2005-05-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the motor domain of the human kinetochore protein CENP-E. J.Mol.Biol., 340, 2004
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1VFV
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![BU of 1vfv by Molmil](/molmil-images/mine/1vfv) | Crystal Structure of the Kif1A Motor Domain Complexed With Mg-AMPPNP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PROTEIN (Fusion protein consisting of Kinesin-like protein KIF1A, ... | Authors: | Nitta, R, Kikkawa, M, Okada, Y, Hirokawa, N. | Deposit date: | 2004-04-19 | Release date: | 2004-08-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | KIF1A Alternately Uses Two Loops to Bind Microtubules Science, 305, 2004
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