PDB: 255 resultsInfo pagesStatus searchChemie searchBIRD

---

6SPH	A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 WITH EBSELEN BOND IN C2 SPACE GROUP Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, N-phenyl-2-selanylbenzamide, ... Authors: Shahid, M, Chantadul, V, Amporndanai, K, Wright, G, Antonyuk, S, Hasnain, S. Deposit date: 2019-09-01 Release date: 2020-03-18 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy. Commun Biol, 3, 2020
6SPI	A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION, ... Authors: Chantadul, V, Amporndanai, K, Wright, G, Antonyuk, S, Hasnain, S. Deposit date: 2019-09-01 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy. Commun Biol, 3, 2020
6A9O	Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Descriptor: 2'-[(6-oxo-5,6-dihydrophenanthridin-3-yl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid, DIMETHYL SULFOXIDE, Dihydrogen tetrasulfide, ... Authors: Manjula, R, Padmanabhan, B. Deposit date: 2018-07-14 Release date: 2019-07-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis. J.Biomol.Struct.Dyn., 37, 2019
6DTK	Heterodimers of FALS mutant SOD enzyme Descriptor: COPPER (II) ION, MALONATE ION, Superoxide dismutase C111S/D83S-C111S HETERODIMER, ... Authors: Streltsov, V.A, Nuttall, S.D, Ganio, K.E, Roberts, B. Deposit date: 2018-06-17 Release date: 2019-06-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural characterization of heterodimers of FALS mutant SOD enzyme To Be Published
6D52	Superoxide dismutase SodCI of Salmonella enterica serovar Typhimurium at 1.6 Angstrom resolution Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn] 1, ZINC ION Authors: Newhouse IX, P.W, Forest, K.T, Satyshur, K.A. Deposit date: 2018-04-19 Release date: 2019-05-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Superoxide dismutase SodCI of Salmonella enterica serovar Typhimurium at 1.6 Angstrom resolution to be published
6FOI	Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION Authors: Wright, G.S.A, Sala, F.A, Antonyuk, S.V, Garratt, R.C, Hasnain, S.S. Deposit date: 2018-02-07 Release date: 2019-01-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. Plos Biol., 17, 2019
6FON	Elongated conformer of the human copper chaperone for SOD1 complexed with human SOD1 Descriptor: Copper chaperone for superoxide dismutase, Superoxide dismutase [Cu-Zn], ZINC ION Authors: Wright, G.S.A, Sala, F.A, Antonyuk, S.V, Garratt, R.C, Hasnain, S.S. Deposit date: 2018-02-07 Release date: 2019-01-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. Plos Biol., 17, 2019
6FN8	Domain II of the HUMAN COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE at 1.55 A resolution Descriptor: Copper chaperone for superoxide dismutase, ZINC ION Authors: Sala, F.A, Wright, G.S.A, Antonyuk, S.V, Garratt, R.C, Hasnain, S.S. Deposit date: 2018-02-02 Release date: 2019-01-30 Last modified: 2019-06-19 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. Plos Biol., 17, 2019
6FP6	Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Descriptor: Copper chaperone for superoxide dismutase, GLYCEROL, PROPANOIC ACID, ... Authors: Sala, F.A, Wright, G.S.A, Antonyuk, S.V, Garratt, R.C, Hasnain, S.S. Deposit date: 2018-02-09 Release date: 2019-01-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3 Å) Cite: Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. Plos Biol., 17, 2019
6FOL	Domain II of the human copper chaperone in complex with human Cu,Zn superoxide dismutase Descriptor: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Copper chaperone for superoxide dismutase, GLYCEROL, ... Authors: Sala, F.A, Wright, G.S.A, Antonyuk, S.V, Garratt, R.C, Hasnain, S.S. Deposit date: 2018-02-07 Release date: 2019-01-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. Plos Biol., 17, 2019
6FFK	Human apo-SOD1 bound to PtCl2(1R,2R-1,4-DACH Descriptor: PtCl2(1(R),2(R)-DACH), Superoxide dismutase [Cu-Zn] Authors: Calderone, V, Nativi, C, Cantini, F, Di Cesare Mannelli, L. Deposit date: 2018-01-08 Release date: 2018-11-28 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Interaction of Half Oxa-/Halfcis-Platin Complex with Human Superoxide Dismutase and Induced Reduction of Neurotoxicity. ACS Med Chem Lett, 9, 2018
5YTU	Structure of human SOD1 complexed with isoproteranol in C2221 space group Descriptor: Dihydrogen tetrasulfide, GLYCEROL, ISOPRENALINE, ... Authors: Manjula, R, Padmanabhan, B. Deposit date: 2017-11-20 Release date: 2018-11-21 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation FEBS Lett., 592, 2018
5YTO	Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Descriptor: 4-[(1~{R})-2-(naphthalen-2-ylmethylamino)-1-oxidanyl-ethyl]benzene-1,2-diol, GLYCEROL, PENTASULFIDE-SULFUR, ... Authors: Padmanabhan, B, Manjula, R. Deposit date: 2017-11-19 Release date: 2018-11-21 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation FEBS Lett., 592, 2018
5YUL	Native Structure of hSOD1 in P6322 space group Descriptor: Dihydrogen tetrasulfide, GLYCEROL, Superoxide dismutase [Cu-Zn], ... Authors: Manjula, R, Padmanabhan, B. Deposit date: 2017-11-22 Release date: 2018-11-21 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation FEBS Lett., 592, 2018
6ADQ	Respiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatis Descriptor: (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... Authors: Gong, H.R, Xu, A, Gao, R.G, Ji, W.X, Wang, S.H, Wang, Q, Li, J, Rao, Z.H. Deposit date: 2018-08-01 Release date: 2018-11-14 Last modified: 2019-11-06 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science, 362, 2018
6FLH	Monomeric Human Cu,Zn Superoxide dismutase, SOD1 7+7, apo form Descriptor: GLYCEROL, SULFATE ION, Superoxide dismutase [Cu-Zn] Authors: Wang, H, Yang, F, Logan, D, Oliveberg, M. Deposit date: 2018-01-25 Release date: 2018-11-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.79 Å) Cite: The Cost of Long Catalytic Loops in Folding and Stability of the ALS-Associated Protein SOD1. J.Am.Chem.Soc., 140, 2018
5O40	SOD1 bound to Ebselen Descriptor: N-phenyl-2-selanylbenzamide, SULFATE ION, Superoxide dismutase [Cu-Zn], ... Authors: Capper, M.J, Wright, G.S.A, Antonyuk, S.V, Hasnain, S.S. Deposit date: 2017-05-25 Release date: 2018-06-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. Nat Commun, 9, 2018
5O3Y	SOD1 bound to Ebsulfur Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION, ... Authors: Capper, M.J, Wright, G.S.A, Antonyuk, S.V, Hasnain, S.S. Deposit date: 2017-05-25 Release date: 2018-06-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. Nat Commun, 9, 2018
5U9M	Copper-Zinc Superoxide Dismutase is Activated through a Sulfenic Acid Intermediate at a Copper-ion Entry Site Descriptor: Superoxide dismutase 1 copper chaperone, Superoxide dismutase [Cu-Zn], ZINC ION Authors: Taylor, A.B, Hart, P.J, Winkler, D.D. Deposit date: 2016-12-16 Release date: 2017-05-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper ion entry site. J. Biol. Chem., 292, 2017
5IN2	Crystal structure of extra cellular Cu/Zn Superoxide Dismutase from Onchocerca volvulus at 1.5 Angstrom; Insight into novel binding site and new inhibitors Descriptor: AZIDE ION, CHLORIDE ION, COPPER (II) ION, ... Authors: Moustafa, A, Betzel, C, Perbandt, M. Deposit date: 2016-03-07 Release date: 2017-03-29 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal structure of extracellular Cu/Zn Superoxide Dismutase from Onchocerca volvulus at 1.5 Angstrom; Insight into novel binding site and new inhibitors To Be Published
5J0G	Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P7/8 Descriptor: OXIDOREDUCTASE,Superoxide dismutase [Cu-Zn] Authors: Wang, H, Lang, L, Logan, D, Danielsson, J, Oliveberg, M. Deposit date: 2016-03-28 Release date: 2017-02-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Tricking a Protein To Swap Strands. J. Am. Chem. Soc., 138, 2016
5J07	Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P1/2 Descriptor: Superoxide dismutase [Cu-Zn],Superoxide dismutase [Cu-Zn],Superoxide dismutase [Cu-Zn],Superoxide dismutase [Cu-Zn] Authors: Wang, H, Lang, L, Logan, D, Danielsson, J, Oliveberg, M. Deposit date: 2016-03-27 Release date: 2017-02-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Tricking a Protein To Swap Strands. J. Am. Chem. Soc., 138, 2016
5J0C	Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P2/3 Descriptor: Superoxide dismutase [Cu-Zn],Superoxide dismutase [Cu-Zn],OXIDOREDUCTASE,Superoxide dismutase [Cu-Zn] Authors: Wang, H, Lang, L, Logan, D, Danielsson, J, Oliveberg, M. Deposit date: 2016-03-28 Release date: 2017-02-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Tricking a Protein To Swap Strands. J. Am. Chem. Soc., 138, 2016
2NAM	Full-length WT SOD1 in DPC MICELLE Descriptor: Superoxide dismutase [Cu-Zn] Authors: Lim, L, Song, J. Deposit date: 2016-01-06 Release date: 2016-12-14 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: SALS-linked WT-SOD1 adopts a highly similar helical conformation as FALS-causing L126Z-SOD1 in a membrane environment Biochim.Biophys.Acta, 1858, 2016
5K02	Structure of human SOD1 with T2D mutation Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION Authors: Fay, J.M, Zhu, C, Cui, W, Ke, H, Dokholyan, N.V. Deposit date: 2016-05-17 Release date: 2016-11-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.99 Å) Cite: A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation. Structure, 24, 2016

<1234567891011>