PDB: 221051 resultsInfo pagesStatus searchChemie searchBIRD

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8TZW	Crystal structure of 10E8-GT4 scaffold in complex with a human 10E8 inferred germline (10E8-iGL1) Descriptor: 10E8-GT4 epitope scaffold, 10E8-IGL1 Fab Light Chain, 10E8-IGL1 Fab heavy chain Authors: Irimia, A, Wilson, I.A. Deposit date: 2023-08-28 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Vaccination induces broadly neutralizing antibody precursors to HIV gp41. Nat.Immunol., 2024
8JN6	Cryo-EM structure of the small tail club shape particle of dengue virus serotype 3 strain CH53489 in complex with human antibody DENV-290 Fab at 37 deg C Descriptor: Human antibody DENV-290 heavy chain, Human antibody DENV-290 light chain, Polyprotein (Fragment) Authors: Fibriansah, G, Ng, T.S, Tan, A.W.K, Shi, J, Lok, S.M. Deposit date: 2023-06-06 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (9.8 Å) Cite: Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants To Be Published
8JN7	Cryo-EM structure of the big tail club shape particle of dengue virus serotype 3 strain CH53489 in complex with human antibody DENV-290 Fab at 37 deg C Descriptor: Human antibody DENV-290 heavy chain, Human antibody DENV-290 light chain, Polyprotein (Fragment) Authors: Fibriansah, G, Ng, T.S, Tan, A.W.K, Shi, J, Lok, S.M. Deposit date: 2023-06-06 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (11 Å) Cite: Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants To Be Published
8U03	Crystal structure of non-glycosylated 10E8-GT10.1 scaffold in complex with a human 10E8 NGS precursor (10E8-NGS-03) Descriptor: 10E8-GT10.1 epitope scaffold, 10E8-NGS-03 Fab Light Chain, 10E8-NGS-03 Fab heavy chain, ... Authors: Irimia, A, Wilson, I.A. Deposit date: 2023-08-28 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Vaccination induces broadly neutralizing antibody precursors to HIV gp41. Nat.Immunol., 2024
8U08	Crystal structure of 10E8-GT11 scaffold in complex with a human 10E8 inferred germline (10E8-iGL1) Descriptor: 10E8-GT11 epitope scaffold, 10E8-IGL1 heavy chain, 10E8-IGL1 light chain, ... Authors: Irimia, A, Wilson, I.A. Deposit date: 2023-08-28 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Vaccination induces broadly neutralizing antibody precursors to HIV gp41. Nat.Immunol., 2024
8JN8	Crystal structure of c-Src in complex with covalent inhibitor DC-Srci-6668 Descriptor: (2R)-N-cyclopentyl-2-[cyclopropyl(ethanoyl)amino]-2-(4-fluorophenyl)ethanamide, Proto-oncogene tyrosine-protein kinase Src Authors: Zhang, H.M, Luo, C. Deposit date: 2023-06-06 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (1.902 Å) Cite: The crystal structure of c-Src in complex with covalent inhibitor DC-Srci-6668 To Be Published
8JN9	Crystal structure of c-Src in complex with covalent inhibitor LW-Srci-8 Descriptor: N-[(1R)-1-[3,5-bis(fluoranyl)phenyl]-2-(cyclopentylamino)-2-oxidanylidene-ethyl]-N-cyclopropyl-prop-2-enamide, Proto-oncogene tyrosine-protein kinase Src Authors: Zhang, H.M, Luo, C. Deposit date: 2023-06-06 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.724 Å) Cite: The crystal structure of c-Src in complex with covalent inhibitor LW-Srci-8 To Be Published
8U5H	Cryo-EM structure of human DNMT3A UDR bound to H2AK119ub1-modified nucleosome Descriptor: DNA (cytosine-5)-methyltransferase 3A, Histone H2A, Histone H2B 1.1, ... Authors: Chen, X, Song, J. Deposit date: 2023-09-12 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Cryo-EM structure of human DNMT3A N-terminal domain bound to H2AK119Ub nucleosome To Be Published
8JNT	RxLR effector RxLR19 from Phytophthora capsici Descriptor: RxLR19781 Authors: Sheng, H, Zhang, X.G. Deposit date: 2023-06-06 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.201 Å) Cite: Phytophthora capsici effector RxLR19 manipulates AsA biosynthesis pathway to promote infection by binding host GME protein To Be Published
8U72	Cryo-EM structure of the SPARTA oligomer with guide RNA and target DNA Descriptor: DNA (5'-D(P*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*C)-3'), MAGNESIUM ION, Piwi domain-containing protein, ... Authors: Malik, R, Kottur, J, Aggarwal, A.K. Deposit date: 2023-09-14 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3.15 Å) Cite: Nucleic acid mediated activation of prokaryotic Argonaute immune system Nat Commun, 2024
8U7B	Crystal structure of Apo form of Short Prokaryotic Argonaute TIR-APAZ (SPARTA) heterodimer Descriptor: MANGANESE (II) ION, PROLINE, Piwi domain-containing protein, ... Authors: Kottur, J, Aggarwal, A.K. Deposit date: 2023-09-15 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Nucleic acid mediated activation of a short prokaryotic Argonaute immune system Nat Commun, 2024
8JNY	Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor Descriptor: 6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide, Poly [ADP-ribose] polymerase 2 Authors: Wang, X.Y, Wang, C.Y, Zhou, J, Xu, B.L. Deposit date: 2023-06-06 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor To Be Published
8JNZ	Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor Descriptor: 6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... Authors: Wang, X.Y, Wang, C.Y, Zhou, J, Xu, B.L. Deposit date: 2023-06-06 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor To Be Published
8U8X	crystal structure of the receptor tyrosine kinase Human HER2 (ERBB2) YVMA mutant kinase domain in complex with inhibitor compound 27 Descriptor: 1-{(1R,3r,5S)-3-[(3M)-4-methyl-3-{3-methyl-4-[(1-methyl-1H-benzimidazol-5-yl)oxy]phenyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-8-azabicyclo[3.2.1]octan-8-yl}propan-1-one, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Wang, J, Mou, T.C. Deposit date: 2023-09-18 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Discovery of Potent and Selective Covalent Inhibitors of HER2 WT and HER2 YVMA. J.Med.Chem., 2024
8UEK	Solution structure of ACKR3-targeting nanobody VUN701 Descriptor: ACKR3-targeting nanobody VUN701 Authors: Schlimgen, R.R, Peterson, F.C, Volkman, B.F. Deposit date: 2023-10-01 Release date: 2024-06-12 Method: SOLUTION NMR Cite: Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies. Nat Commun, 15, 2024
8JOF	solution-structure of Ras Binding Domain (RBD) in C-RAF Descriptor: RAF proto-oncogene serine/threonine-protein kinase Authors: Makino, Y, Matsumoto, S, Yoshikawa, Y, Kawamura, T, Kumasaka, T, Shima, F. Deposit date: 2023-06-07 Release date: 2024-06-12 Method: SOLUTION NMR Cite: Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers To Be Published
8UIR	SARS-CoV-2 Omicron-XBB.1.16 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-XBB.1.16) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Zhang, Q.E, Acharya, P. Deposit date: 2023-10-10 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: SARS-CoV-2 Omicron-XBB.1.16 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-XBB.1.16) To Be Published
8JOG	solution structure of Ras Binding Domein (RBD) in C-RAF with negative allosteric modulator. Descriptor: RAF proto-oncogene serine/threonine-protein kinase Authors: Makino, Y, Matsumoto, S, Yoshikawa, Y, Kawamura, T, Kumasaka, T, Shima, F. Deposit date: 2023-06-07 Release date: 2024-06-12 Method: SOLUTION NMR Cite: Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers To Be Published
8JOH	structure of Echinococcus multilocularis Cystatin B Descriptor: Cystatin B Stefin B Authors: Huang, S.Q, Hong, W.B. Deposit date: 2023-06-07 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Crystal Structure of Echinococcus multilocularis Cystatin B To Be Published
8UK1	SARS-CoV-2 Omicron-XBB.1.16 3-RBD-down Spike Protein Trimer consensus (S-RRAR-Omicron-XBB.1.16) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Zhang, Q.E, Acharya, P. Deposit date: 2023-10-11 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3 Å) Cite: SARS-CoV-2 Omicron-XBB.1.16 3-RBD-down Spike Protein Trimer consensus (S-RRAR-Omicron-XBB.1.16) To Be Published
8UKW	Crystal structure the extracellular region of the epidermal growth factor receptor variant III (EGFRvIII) at pH 5.0 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... Authors: Stayrook, S.E, Ferguson, K.M. Deposit date: 2023-10-15 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Structural insights into the role and targeting of EGFRvIII Structure, 2024
8JON	Structure of a synthetic circadian clock protein KaiC mutant of cyanobacteria Synechococcus elongatus PCC 7942 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Circadian clock oscillator protein KaiC, ... Authors: Jia, X, Zhang, Q, Li, S, Guo, J. Deposit date: 2023-06-07 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.51 Å) Cite: Adaptation of ancient cyanobacterial clock to the day length ~ 0.95 Ga ago To Be Published
8JOW	Crystal structure of rabbit antibody with phosphorylated peptide bound Descriptor: ARG-PRO-HIS-PHE-PRO-GLN-PHE-SEP-TYR-SER-ALA-SER, Antibody (scFv), CHLORIDE ION Authors: Caaveiro, J.M.M, Kawade, R, Tsumoto, K. Deposit date: 2023-06-08 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Origin of high binding affinity and selectivity of phosphorylated epitope-specific rabbit antibodies To Be Published
8UKX	Crystal structure the extracellular region of the epidermal growth factor receptor variant III (EGFRvIII) at pH 7.0 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Stayrook, S.E, Ferguson, K.M. Deposit date: 2023-10-15 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (3.301 Å) Cite: Structural insights into the role and targeting of EGFRvIII Structure, 2024
8UQ6	Human Plasminogen bound to streptococcal surface enolase Descriptor: Plasminogen Authors: Tjia-Fleck, S, Readnour, B.M, Castellino, F.J. Deposit date: 2023-10-23 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Streptococcus surface alpha enolase exposed dimers were found to be the active form on lipid surface that binds to human plasminogen To Be Published

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