8JOF

solution-structure of Ras Binding Domain (RBD) in C-RAF

Summary for 8JOF

• Entry DOI: 10.2210/pdb8jof/pdb
• Descriptor: RAF proto-oncogene serine/threonine-protein kinase (1 entity in total)
• Functional Keywords: mapk, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 9615.22

Authors

Makino, Y.,Matsumoto, S.,Yoshikawa, Y.,Kawamura, T.,Kumasaka, T.,Shima, F. (deposition date: 2023-06-07, release date: 2024-06-12)

• Primary citation: Yoshikawa, Y.,Makino, Y.,Hirokazu, K.,Kawamura, T.,Matsumoto, S.,Yuki, H.,Shibaike, A.,Okamura, M.,Okada, T.,Kataoka, T.,Honma, T.,Kumasaka, T.,Koyama, H.,Shima, F.; Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers; To Be Published,

Experimental method

SOLUTION NMR