PDB: 6545 resultsInfo pagesStatus searchChemie searchBIRD

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3QGT	Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Chitnumsub, P, Yuthavong, Y. Deposit date: 2011-01-24 Release date: 2011-06-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Trypanosomal dihydrofolate reductase reveals natural antifolate resistance Acs Chem.Biol., 6, 2011
3QB8	Paramecium Chlorella Bursaria Virus1 Putative ORF A654L is a Polyamine Acetyltransferase Descriptor: A654L protein, COENZYME A, IMIDAZOLE Authors: Charlop-Powers, Z, Zhou, M.-M, Jakoncic, J, Gurnon, J, Van Etten, J. Deposit date: 2011-01-12 Release date: 2012-01-25 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Paramecium bursaria chlorella virus 1 encodes a polyamine acetyltransferase. J. Biol. Chem., 287, 2012
3QG2	Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Vanichtanankul, J, Yuvaniyama, J, Taweechai, S, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y. Deposit date: 2011-01-24 Release date: 2011-06-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Trypanosomal dihydrofolate reductase reveals natural antifolate resistance Acs Chem.Biol., 6, 2011
3RI6	A Novel Mechanism of Sulfur Transfer Catalyzed by O-Acetylhomoserine Sulfhydrylase in Methionine Biosynthetic Pathway of Wolinella succinogenes Descriptor: O-ACETYLHOMOSERINE SULFHYDRYLASE Authors: Tran, T.H, Krishnamoorthy, K, Begley, T.P, Ealick, S.E. Deposit date: 2011-04-13 Release date: 2011-08-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes. Acta Crystallogr.,Sect.D, 67, 2011
3U0E	Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with fragment 9320 Descriptor: 8-methylquinolin-4-amine, Beta-ketoacyl synthase, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-09-28 Release date: 2011-10-26 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites. Proteins, 88, 2020
3RR2	Structure of a Cysteine synthase (O-Acetylserine Sulfhydrylase (OASS)) from Mycobacterium marinum ATCC BAA-535 / M Descriptor: Cysteine synthase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-04-28 Release date: 2011-05-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
3RBM	Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH -703 Descriptor: 3-(2,2-diphosphonoethyl)-1-dodecyl-1H-imidazol-3-ium, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... Authors: Liu, Y.L, No, J.H, Oldfield, E. Deposit date: 2011-03-29 Release date: 2012-02-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc.Natl.Acad.Sci.USA, 109, 2012
3R96	Crystal structure of Microcin C7 self immunity acetyltransferase MccE in complex with Acetyl-CoA and AMP Descriptor: ACETYL COENZYME *A, ADENOSINE MONOPHOSPHATE, MccE protein Authors: Nair, S.K, Agarwal, V. Deposit date: 2011-03-24 Release date: 2011-04-20 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structural Basis for Microcin C7 Inactivation by the MccE Acetyltransferase. J.Biol.Chem., 286, 2011
3SGX	Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1100 Descriptor: 4-{3-[(biphenyl-4-ylcarbonyl)amino]phenoxy}benzene-1,2-dicarboxylic acid, Undecaprenyl pyrophosphate synthase Authors: Cao, R, Liu, Y.-L, Oldfield, E. Deposit date: 2011-06-15 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Antibacterial drug leads targeting isoprenoid biosynthesis. Proc.Natl.Acad.Sci.USA, 110, 2013
3S7Y	Crystal structure of mmNAGS in Space Group P3121 at 4.3 A resolution Descriptor: N-acetylglutamate kinase / N-acetylglutamate synthase Authors: Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. Deposit date: 2011-05-27 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (4.3077 Å) Cite: A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris. Plos One, 6, 2011
3U0F	The structure of Beta-ketoacyl synthase from Brucella melitensis bound to the fragment 7-hydroxycoumarin Descriptor: 7-hydroxy-2H-chromen-2-one, Beta-ketoacyl synthase, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-09-28 Release date: 2011-10-12 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites. Proteins, 88, 2020
3UBO	The crystal structure of adenosine kinase from Sinorhizobium meliloti Descriptor: ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, adenosine kinase Authors: Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) Deposit date: 2011-10-24 Release date: 2011-11-09 Method: X-RAY DIFFRACTION (2.601 Å) Cite: The crystal structure of adenosine kinase from Sinorhizobium meliloti To be Published
3TR1	Structure of a 3-phosphoshikimate 1-carboxyvinyltransferase (aroA) from Coxiella burnetii Descriptor: 3-phosphoshikimate 1-carboxyvinyltransferase, PHOSPHATE ION, POTASSIUM ION Authors: Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. Deposit date: 2011-09-09 Release date: 2011-09-28 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
3TTQ	Crystal structure of Leuconostoc mesenteroides NRRL B-1299 N-terminally truncated dextransucrase DSR-E in orthorhombic apo-form at 1.9 angstrom resolution Descriptor: CALCIUM ION, Dextransucrase, GLYCEROL, ... Authors: Brison, Y, Pijning, T, Fabre, E, Mourey, L, Morel, S, Potocki-Veronese, G, Monsan, P, Remaud-Simeon, M, Dijkstra, B.W, Tranier, S. Deposit date: 2011-09-15 Release date: 2012-01-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Functional and structural characterization of alpha-(1-2) branching sucrase derived from DSR-E glucansucrase J.Biol.Chem., 287, 2012
3TMS	PLASTIC ADAPTATION TOWARD MUTATIONS IN PROTEINS: STRUCTURAL COMPARISON OF THYMIDYLATE SYNTHASES Descriptor: PHOSPHATE ION, THYMIDYLATE SYNTHASE Authors: Perry, K.M, Stroud, R.M. Deposit date: 1991-09-19 Release date: 1991-10-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins, 8, 1990
3UM5	Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Vanichtanankul, J, Kamchonwongpaisan, S, Chitnumsub, P, Yuthavong, Y. Deposit date: 2011-11-12 Release date: 2012-07-18 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil. Antimicrob.Agents Chemother., 56, 2012
3UM6	Double mutant (A16V+S108T) Plasmodium falciparum DHFR-TS (T9/94) complexed with cycloguanil, NADPH and dUMP Descriptor: 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Vanichtanankul, J, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y. Deposit date: 2011-11-12 Release date: 2012-07-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil. Antimicrob.Agents Chemother., 56, 2012
3UY5	crystal structure of Eis from Mycobacterium tuberculosis Descriptor: Enhanced intracellular survival protein Authors: Kim, K.H, Suh, S.W. Deposit date: 2011-12-05 Release date: 2012-05-23 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7 Proc.Natl.Acad.Sci.USA, 2012
3UM8	Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH Descriptor: 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Vanichtanankul, J, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y. Deposit date: 2011-11-12 Release date: 2012-07-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil. Antimicrob.Agents Chemother., 56, 2012
3UR1	The structure of a ternary complex between CheA domains P4 and P5 with CheW and with a truncated fragment of TM14, a chemoreceptor analog from Thermotoga maritima. Descriptor: Chemotaxis protein CheA, Chemotaxis protein CheW, Methyl-accepting chemotaxis protein Authors: Li, X, Crane, B.R, Bilwes, A.M. Deposit date: 2011-11-21 Release date: 2012-03-07 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (4.5 Å) Cite: The structure of native bacterial chemoreceptor arrays Proc.Natl.Acad.Sci.USA, 2012

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