3UM6

Double mutant (A16V+S108T) Plasmodium falciparum DHFR-TS (T9/94) complexed with cycloguanil, NADPH and dUMP

Summary for 3UM6

• Entry DOI: 10.2210/pdb3um6/pdb
• Related: 3UM6 3UM8
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• Functional Keywords: malarial dhfr-ts, cycloguanil, antifolate, napdh, dump, oxidoreductase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 2
• Total formula weight: 146350.79

Authors

Vanichtanankul, J.,Chitnumsub, P.,Kamchonwongpaisan, S.,Yuthavong, Y. (deposition date: 2011-11-12, release date: 2012-07-18, Last modification date: 2024-03-20)

• Primary citation: Vanichtanankul, J.,Taweechai, S.,Uttamapinant, C.,Chitnumsub, P.,Vilaivan, T.,Yuthavong, Y.,Kamchonwongpaisan, S.; Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil.; Antimicrob.Agents Chemother., 56:3928-3935, 2012; PubMed: 22526319; DOI: 10.1128/AAC.00301-12

Experimental method

X-RAY DIFFRACTION (2.65 Å)