3RBM

Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH -703

Summary for 3RBM

Entry DOI	10.2210/pdb3rbm/pdb
Related	3RYW
Descriptor	Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-(2,2-diphosphonoethyl)-1-dodecyl-1H-imidazol-3-ium, ... (5 entities in total)
Functional Keywords	alpha-helices, isoprene biosynthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Plasmodium vivax
Total number of polymer chains	4
Total formula weight	187240.58
Authors	Liu, Y.L.,No, J.H.,Oldfield, E. (deposition date: 2011-03-29, release date: 2012-02-29, Last modification date: 2023-09-13)
Primary citation	No, J.H.,de Macedo Dossin, F.,Zhang, Y.,Liu, Y.L.,Zhu, W.,Feng, X.,Yoo, J.A.,Lee, E.,Wang, K.,Hui, R.,Freitas-Junior, L.H.,Oldfield, E. Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc.Natl.Acad.Sci.USA, 109:4058-4063, 2012 Cited by PubMed: 22392982 DOI: 10.1073/pnas.1118215109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation