3RBM
Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH -703
Summary for 3RBM
Entry DOI | 10.2210/pdb3rbm/pdb |
Related | 3RYW |
Descriptor | Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-(2,2-diphosphonoethyl)-1-dodecyl-1H-imidazol-3-ium, ... (5 entities in total) |
Functional Keywords | alpha-helices, isoprene biosynthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Plasmodium vivax |
Total number of polymer chains | 4 |
Total formula weight | 187240.58 |
Authors | Liu, Y.L.,No, J.H.,Oldfield, E. (deposition date: 2011-03-29, release date: 2012-02-29, Last modification date: 2023-09-13) |
Primary citation | No, J.H.,de Macedo Dossin, F.,Zhang, Y.,Liu, Y.L.,Zhu, W.,Feng, X.,Yoo, J.A.,Lee, E.,Wang, K.,Hui, R.,Freitas-Junior, L.H.,Oldfield, E. Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc.Natl.Acad.Sci.USA, 109:4058-4063, 2012 Cited by PubMed: 22392982DOI: 10.1073/pnas.1118215109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
Download full validation report