3RBM
Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH -703
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| C | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| C | 0004659 | molecular_function | prenyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| D | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| D | 0004659 | molecular_function | prenyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008299 | biological_process | isoprenoid biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| D | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1001 |
| Chain | Residue |
| A | ASP287 |
| A | HOH423 |
| A | HOH465 |
| A | HOH467 |
| A | B732001 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | HOH463 |
| A | MG1003 |
| A | B732001 |
| A | ASP126 |
| A | ASP130 |
| A | HOH407 |
| A | HOH462 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1003 |
| Chain | Residue |
| A | ASP126 |
| A | ASP130 |
| A | HOH466 |
| A | MG1002 |
| A | B732001 |
| site_id | AC4 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE B73 A 2001 |
| Chain | Residue |
| A | ALA125 |
| A | ASP126 |
| A | ASP130 |
| A | ARG135 |
| A | VAL156 |
| A | THR191 |
| A | GLN195 |
| A | LYS243 |
| A | THR244 |
| A | ASP287 |
| A | LYS301 |
| A | HOH407 |
| A | HOH423 |
| A | HOH454 |
| A | HOH462 |
| A | HOH464 |
| A | HOH465 |
| A | HOH466 |
| A | HOH467 |
| A | MG1001 |
| A | MG1002 |
| A | MG1003 |
| B | VAL153 |
| B | ASN154 |
| B | LEU157 |
| B | B732001 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3001 |
| Chain | Residue |
| A | LYS81 |
| A | GLN119 |
| A | ARG136 |
| A | HOH427 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1001 |
| Chain | Residue |
| B | ASP287 |
| B | HOH476 |
| B | HOH477 |
| B | B732001 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1002 |
| Chain | Residue |
| B | ASP126 |
| B | ASP130 |
| B | GLN195 |
| B | ASP198 |
| B | HOH478 |
| B | B732001 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1003 |
| Chain | Residue |
| B | ASP126 |
| B | ASP130 |
| B | HOH475 |
| B | B732001 |
| site_id | AC9 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE B73 B 2001 |
| Chain | Residue |
| A | VAL153 |
| A | ASN154 |
| A | LEU157 |
| A | B732001 |
| B | PHE122 |
| B | ASP126 |
| B | ASP130 |
| B | ARG135 |
| B | VAL153 |
| B | VAL156 |
| B | THR191 |
| B | GLN195 |
| B | LYS243 |
| B | THR244 |
| B | ASP287 |
| B | LYS301 |
| B | HOH405 |
| B | HOH412 |
| B | HOH475 |
| B | HOH476 |
| B | HOH478 |
| B | MG1001 |
| B | MG1002 |
| B | MG1003 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 3001 |
| Chain | Residue |
| B | GLY80 |
| B | LYS81 |
| B | GLN119 |
| B | ARG136 |
| B | HOH436 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 1001 |
| Chain | Residue |
| C | ASP287 |
| C | ASP291 |
| C | ASP305 |
| C | B732001 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG C 1002 |
| Chain | Residue |
| C | HOH452 |
| C | B732001 |
| C | ASP126 |
| C | ASP130 |
| C | GLN195 |
| C | ASP198 |
| C | HOH432 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 1003 |
| Chain | Residue |
| C | ASP126 |
| C | ASP130 |
| C | HOH451 |
| C | B732001 |
| site_id | BC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE B73 C 2001 |
| Chain | Residue |
| C | PHE122 |
| C | ALA125 |
| C | ASP126 |
| C | ASP130 |
| C | ARG135 |
| C | VAL156 |
| C | GLN195 |
| C | LYS243 |
| C | THR244 |
| C | ASP287 |
| C | LYS301 |
| C | HOH401 |
| C | HOH432 |
| C | HOH451 |
| C | HOH452 |
| C | MG1001 |
| C | MG1002 |
| C | MG1003 |
| D | VAL153 |
| D | LEU157 |
| D | B732001 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 3001 |
| Chain | Residue |
| C | GLY80 |
| C | LYS81 |
| C | GLN119 |
| C | ARG136 |
| C | HOH428 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 1001 |
| Chain | Residue |
| D | ASP287 |
| D | ASP305 |
| D | HOH448 |
| D | HOH453 |
| D | B732001 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG D 1002 |
| Chain | Residue |
| D | ASP126 |
| D | ASP130 |
| D | HOH447 |
| D | HOH450 |
| D | HOH451 |
| D | MG1003 |
| D | B732001 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 1003 |
| Chain | Residue |
| D | ASP126 |
| D | ASP130 |
| D | HOH449 |
| D | HOH452 |
| D | MG1002 |
| D | B732001 |
| site_id | CC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE B73 D 2001 |
| Chain | Residue |
| C | VAL153 |
| C | ASN154 |
| C | LEU157 |
| C | B732001 |
| D | ALA125 |
| D | ASP126 |
| D | ASP130 |
| D | ARG135 |
| D | VAL156 |
| D | GLN195 |
| D | LYS243 |
| D | THR244 |
| D | ASP287 |
| D | LYS301 |
| D | HOH447 |
| D | HOH448 |
| D | HOH449 |
| D | HOH451 |
| D | HOH452 |
| D | HOH453 |
| D | MG1001 |
| D | MG1002 |
| D | MG1003 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 3001 |
| Chain | Residue |
| D | LYS81 |
| D | GLN119 |
| D | ARG136 |
| D | HOH430 |
Functional Information from PROSITE/UniProt
| site_id | PS00444 |
| Number of Residues | 13 |
| Details | POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGeyFQIhDDYlD |
| Chain | Residue | Details |
| A | MET279-ASP291 |
