3UM5

Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP

Summary for 3UM5

Entry DOI	10.2210/pdb3um5/pdb
Related	3UM6 3UM8
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	malarial dhfr-ts, pyrimethamine, antifolate, napdh, dump, oxidoreductase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Plasmodium falciparum
Total number of polymer chains	2
Total formula weight	146344.78
Authors	Vanichtanankul, J.,Kamchonwongpaisan, S.,Chitnumsub, P.,Yuthavong, Y. (deposition date: 2011-11-12, release date: 2012-07-18, Last modification date: 2023-11-01)
Primary citation	Vanichtanankul, J.,Taweechai, S.,Uttamapinant, C.,Chitnumsub, P.,Vilaivan, T.,Yuthavong, Y.,Kamchonwongpaisan, S. Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil. Antimicrob.Agents Chemother., 56:3928-3935, 2012 Cited by PubMed: 22526319 DOI: 10.1128/AAC.00301-12 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation