3UM5
Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP
Summary for 3UM5
Entry DOI | 10.2210/pdb3um5/pdb |
Related | 3UM6 3UM8 |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | malarial dhfr-ts, pyrimethamine, antifolate, napdh, dump, oxidoreductase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 2 |
Total formula weight | 146344.78 |
Authors | Vanichtanankul, J.,Kamchonwongpaisan, S.,Chitnumsub, P.,Yuthavong, Y. (deposition date: 2011-11-12, release date: 2012-07-18, Last modification date: 2023-11-01) |
Primary citation | Vanichtanankul, J.,Taweechai, S.,Uttamapinant, C.,Chitnumsub, P.,Vilaivan, T.,Yuthavong, Y.,Kamchonwongpaisan, S. Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil. Antimicrob.Agents Chemother., 56:3928-3935, 2012 Cited by PubMed: 22526319DOI: 10.1128/AAC.00301-12 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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