PDB: 19255 resultsInfo pagesStatus searchChemie searchBIRD

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4OC3	X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with CFIBzL, a urea-based inhibitor N~2~-{[(1S)-1-carboxy-2-(furan-2-yl)ethyl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Pavlicek, J, Ptacek, J, Cerny, J, Byun, Y, Skultetyova, L, Pomper, M, Lubkowski, J, Barinka, C. Deposit date: 2014-01-08 Release date: 2014-05-21 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II. Bioorg.Med.Chem.Lett., 24, 2014
4OME	X-ray structure of human glutamate carboxypeptidase II in complex with DCCBL, a urea based inhibitor with distal carborane moiety Descriptor: (S)-2-(3-((S)-1-carboxy-5-(1,2-dicarba-closo-dodecarboranylamido) pentyl)ureido)pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Barinka, C, Ptacek, J, Novakova, Z, Byun, Y. Deposit date: 2014-01-27 Release date: 2015-02-18 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.79 Å) Cite: X-ray structure of human glutamate carboxypeptidase II in complex with DCCBL, a urea based inhibitor with distal carborane moiety To be Published
4OO3	Crystal structure of a putative oxidoreductase (PARMER_00841) from Parabacteroides merdae ATCC 43184 at 2.23 A resolution Descriptor: hypothetical protein Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2014-01-30 Release date: 2014-03-05 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Crystal structure of a hypothetical protein (PARMER_00841) from Parabacteroides merdae ATCC 43184 at 2.23 A resolution To be published
4OZ1	Crystal structure of human CAPERalpha UHM bound to SF3b155 ULM5 Descriptor: CHLORIDE ION, LYSINE, POTASSIUM ION, ... Authors: Loerch, S, Kielkopf, C.L. Deposit date: 2014-02-13 Release date: 2014-05-14 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Cancer-relevant splicing factor CAPER alpha engages the essential splicing factor SF3b155 in a specific ternary complex. J.Biol.Chem., 289, 2014
4HI4	Crystal structure of the 5-coordinate ferric heme-binding PAS domain of Aer2 from P. aeruginosa Descriptor: Aerotaxis transducer Aer2, CHLORIDE ION, GLYCEROL, ... Authors: Airola, M.V, Crane, B.R. Deposit date: 2012-10-11 Release date: 2013-01-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.304 Å) Cite: Architecture of the soluble receptor Aer2 indicates an in-line mechanism for PAS and HAMP domain signaling. J.Mol.Biol., 425, 2013
8SU8	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde). Descriptor: (6P)-6-(furan-2-yl)-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... Authors: Bruystens, J.G.H. Deposit date: 2023-05-11 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023
4HPT	Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete phosphoryl transfer of AMP-PNP onto a substrate peptide Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, cAMP-dependent protein kinase catalytic subunit alpha, ... Authors: Bastidas, A.C, Steichen, J.M, Wu, J, Taylor, S.S. Deposit date: 2012-10-24 Release date: 2013-03-20 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Phosphoryl transfer by protein kinase a is captured in a crystal lattice. J.Am.Chem.Soc., 135, 2013
4HPU	Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying partial phosphoryl transfer of AMP-PNP onto a substrate peptide Descriptor: MAGNESIUM ION, MYRISTIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Bastidas, A.C, Steichen, J.M, Wu, J, Taylor, S.S. Deposit date: 2012-10-24 Release date: 2013-03-20 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Phosphoryl transfer by protein kinase a is captured in a crystal lattice. J.Am.Chem.Soc., 135, 2013
4IAK	Low temperature X-ray structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20 Descriptor: ADENOSINE-5'-DIPHOSPHATE, CARBONATE ION, STRONTIUM ION, ... Authors: Gerlits, O, Kovalevsky, A. Deposit date: 2012-12-06 Release date: 2013-06-12 Last modified: 2013-12-18 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
4IAY	Room temperature X-ray Structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20 Descriptor: ADENOSINE-5'-DIPHOSPHATE, STRONTIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... Authors: Gerlits, O, Kovalevsky, A. Deposit date: 2012-12-07 Release date: 2013-06-12 Last modified: 2013-12-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
4IAF	Room temperature X-ray Structure OF cAMP dependent protein kinase A in complex with high Mg2+ concentration, ADP and phosphorylated peptide pSP20 Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... Authors: Gerlits, O, Kovalevsky, A. Deposit date: 2012-12-06 Release date: 2013-06-12 Last modified: 2013-12-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
6V6D	Cryo-EM structure of human pannexin 1 Descriptor: Pannexin-1 Authors: Deng, Z, He, Z, Yuan, P. Deposit date: 2019-12-05 Release date: 2020-04-01 Last modified: 2020-04-22 Method: ELECTRON MICROSCOPY (3.77 Å) Cite: Cryo-EM structures of the ATP release channel pannexin 1. Nat.Struct.Mol.Biol., 27, 2020
8T1D	Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD Descriptor: (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera Authors: Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. Deposit date: 2023-06-02 Release date: 2023-07-05 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
8T1B	Cryo-EM structure of full-length human TRPV4 in apo state Descriptor: (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, ... Authors: Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. Deposit date: 2023-06-02 Release date: 2023-07-05 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
8T1F	Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047 Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera Authors: Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. Deposit date: 2023-06-02 Release date: 2023-07-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
8T1E	Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD Descriptor: (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, ... Authors: Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. Deposit date: 2023-06-02 Release date: 2023-07-05 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
8T2U	Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids complexed with Eptifibatide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. Deposit date: 2023-06-06 Release date: 2023-07-26 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids. Nat Commun, 14, 2023
8T2V	Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. Deposit date: 2023-06-06 Release date: 2023-07-26 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids. Nat Commun, 14, 2023
4IAC	X-RAY structure of cAMP dependent protein kinase A in complex with HIGH MG2+ concentration, AMP-PCP AND pseudo-substrate peptide SP20 Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Peptide SP20, ... Authors: Gerlits, O, Kovalevsky, A. Deposit date: 2012-12-06 Release date: 2013-06-12 Last modified: 2016-09-21 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
4IAI	X-ray Structure of cAMP dependent protein kinase A in complex with high Ca2+ concentration, ADP and phosphorylated peptide pSP20 Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CARBONATE ION, ... Authors: Gerlits, O, Kovalevsky, A. Deposit date: 2012-12-06 Release date: 2013-06-12 Last modified: 2013-12-18 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
4IB3	Structure of cAMP dependent protein kinase A in complex with ADP, phosphorylated peptide pSP20, and no metal Descriptor: ADENOSINE-5'-DIPHOSPHATE, cAMP-dependent protein kinase catalytic subunit alpha, phosphorylated pseudo-substrate peptide pSP20 Authors: Gerlits, O, Kovalevsky, A. Deposit date: 2012-12-07 Release date: 2013-12-11 Last modified: 2014-05-28 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer. Biochemistry, 53, 2014
8T7V	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde) Descriptor: (7M)-7-(furan-2-yl)-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... Authors: Bruystens, J.G.H. Deposit date: 2023-06-21 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023
8T09	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-ethynyl-2-hydroxy-1-naphthaldehyde) Descriptor: 6-ethynyl-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... Authors: Bruystens, J.G.H. Deposit date: 2023-05-31 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023
4GVC	Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with phosphorylated Syndecan1 Peptide Descriptor: 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID), CHLORIDE ION, SODIUM ION, ... Authors: Liu, X, Shepherd, T.R, Murray, A.M, Xu, Z, Fuentes, E.J. Deposit date: 2012-08-30 Release date: 2013-03-13 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.54 Å) Cite: The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics. Structure, 21, 2013
4HE2	Crystal structure of human muscle fructose-1,6-bisphosphatase Q32R mutant complex with AMP Descriptor: ADENOSINE MONOPHOSPHATE, CHLORIDE ION, Fructose-1,6-bisphosphatase isozyme 2, ... Authors: Shi, R, Zhu, D.W, Lin, S.X. Deposit date: 2012-10-03 Release date: 2013-10-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway. Plos One, 8, 2013

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