PDB: 36667 resultsInfo pagesStatus searchChemie searchBIRD

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7P03	Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation without nucleotides Descriptor: Pleiotropic ABC efflux transporter of multiple drugs Authors: Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. Deposit date: 2021-06-29 Release date: 2021-11-10 Method: ELECTRON MICROSCOPY (3.45 Å) Cite: Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
7P04	Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation with ADP/ATP Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Pleiotropic ABC efflux transporter of multiple drugs Authors: Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. Deposit date: 2021-06-29 Release date: 2021-11-10 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
7P00	Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex Descriptor: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. Deposit date: 2021-06-29 Release date: 2021-12-15 Method: ELECTRON MICROSCOPY (2.71 Å) Cite: Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
7P02	Human Neurokinin 1 receptor (NK1R) substance P Gs complex Descriptor: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. Deposit date: 2021-06-29 Release date: 2021-12-15 Method: ELECTRON MICROSCOPY (2.87 Å) Cite: Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
7R9L	Crystal structure of HPK1 in complex with compound 2 Descriptor: 2-amino-N,N-dimethyl-5-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide, Hematopoietic progenitor kinase Authors: Wu, P, Lehoux, I, Wang, W. Deposit date: 2021-06-29 Release date: 2022-01-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.332 Å) Cite: Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13, 2022
7R9P	Crystal structure of HPK1 in complex with compound 14 Descriptor: 6-amino-2-fluoro-N,N-dimethyl-3-(4'-methylspiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl)benzamide, Hematopoietic progenitor kinase, SULFATE ION Authors: Wu, P, Lehoux, I, Wang, W. Deposit date: 2021-06-29 Release date: 2022-01-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13, 2022
7R9T	Crystal structure of HPK1 in complex with compound 17 Descriptor: 6-amino-3-[(1S,3R)-4'-chloro-3-hydroxy-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl]-2-fluoro-N,N-dimethylbenzamide, Hematopoietic progenitor kinase Authors: Wu, P, Lehoux, I, Wang, W. Deposit date: 2021-06-29 Release date: 2022-01-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13, 2022
7R9N	Crystal structure of HPK1 in complex with GNE1858 Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hematopoietic progenitor kinase, ... Authors: Wu, P, Lehoux, I, Wang, W. Deposit date: 2021-06-29 Release date: 2022-01-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13, 2022
7RA3	cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP Descriptor: Gastric inhibitory polypeptide, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. Deposit date: 2021-06-29 Release date: 2022-04-13 Method: ELECTRON MICROSCOPY (3.24 Å) Cite: Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
7R94	T-Plastin-F-actin complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... Authors: Mei, L, Alushin, G.M. Deposit date: 2021-06-28 Release date: 2022-07-06 Last modified: 2022-09-21 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Structural mechanism for bidirectional actin cross-linking by T-plastin. Proc.Natl.Acad.Sci.USA, 119, 2022
7R97	Crystal structure of postcleavge complex of Escherichia coli RNase III Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... Authors: Dharavath, S, Shaw, G.X, Ji, X. Deposit date: 2021-06-28 Release date: 2022-07-20 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.804 Å) Cite: Structural basis for Dicer-like function of an engineered RNase III variant and insights into the reaction trajectory of two-Mg 2+ -ion catalysis. Rna Biol., 19, 2022
7R91	cryo-EM structure of the rigor state wild type myosin-15-F-actin complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... Authors: Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. Deposit date: 2021-06-28 Release date: 2021-07-28 Last modified: 2022-08-03 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
7OZW	Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with fragment 166 at the transient P-pocket Descriptor: (1~{R},2~{R})-2-phenyl-~{N}-(1,3-thiazol-2-yl)cyclopropane-1-carboxamide, DNA (37-MER), Reverse transcriptase/ribonuclease H Authors: Singh, A.K, Das, K. Deposit date: 2021-06-28 Release date: 2021-12-08 Last modified: 2021-12-22 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - targeting P-pocket by fragment screening. Nat Commun, 12, 2021
7OZJ	CryoEM structure of human enterovirus 70 empty particle Descriptor: VP1, VP2, VP3 Authors: Fuzik, T, Plevka, P, Moravcova, J. Deposit date: 2021-06-28 Release date: 2022-07-13 Last modified: 2022-09-28 Method: ELECTRON MICROSCOPY (4.29 Å) Cite: Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds. J.Virol., 96, 2022
7OZI	CryoEM structure of human enterovirus 70 A-particle Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 Authors: Fuzik, T, Plevka, P, Moravcova, J. Deposit date: 2021-06-28 Release date: 2022-07-13 Last modified: 2022-09-28 Method: ELECTRON MICROSCOPY (3.73 Å) Cite: Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds. J.Virol., 96, 2022
7OZK	CryoEM structure of human enterovirus 70 in complex with Pleconaril Descriptor: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE, Capsid protein VP1, Capsid protein VP2, ... Authors: Fuzik, T, Plevka, P, Moravcova, J. Deposit date: 2021-06-28 Release date: 2022-07-27 Last modified: 2022-09-28 Method: ELECTRON MICROSCOPY (2.31 Å) Cite: Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds. J.Virol., 96, 2022
7OZL	CryoEM structure of human enterovirus 70 in complex with WIN51711 Descriptor: 5-(7-(4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE, Capsid protein VP1, Capsid protein VP2, ... Authors: Fuzik, T, Plevka, P, Moravcova, J. Deposit date: 2021-06-28 Release date: 2022-07-27 Last modified: 2022-09-28 Method: ELECTRON MICROSCOPY (2.74 Å) Cite: Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds. J.Virol., 96, 2022
7R8U	LOX-1 - Structural and Functional Studies of a Receptor Implicated in Atherosclerosis Descriptor: Antibody light chain, kappa, Antigen binding fragment, ... Authors: Oganesyan, V, van Dyk, N. Deposit date: 2021-06-27 Release date: 2022-06-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.901 Å) Cite: Structural and functional studies of a monoclonal antibody blocking LOX-1 Commun Med, 2023
7R8S	The crystal structure of CYP199A4 bound to 4-n-propylbenzoic acid Descriptor: 4-propylbenzoic acid, CHLORIDE ION, Cytochrome P450, ... Authors: Podgorski, M.N, Bell, S.G. Deposit date: 2021-06-27 Release date: 2022-06-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.366 Å) Cite: Exploring the Factors which Result in Cytochrome P450 Catalyzed Desaturation Versus Hydroxylation. Chem Asian J, 17, 2022
7R8T	High-resolution crystal structure of CYP199A4 bound to 4-ethylbenzoic acid Descriptor: 4-ethylbenzoic acid, CHLORIDE ION, Cytochrome P450, ... Authors: Podgorski, M.N, Bell, S.G. Deposit date: 2021-06-27 Release date: 2022-06-29 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.366 Å) Cite: High-resolution crystal structure of CYP199A4 bound to 4-ethylbenzoic acid To Be Published
7R8V	Cryo-EM structure of the ADP state actin filament Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... Authors: Gong, R, Espinosa de los Reyes, S, Reynolds, M.J, Gurel, P, Alushin, G.M. Deposit date: 2021-06-27 Release date: 2021-07-28 Last modified: 2022-08-03 Method: ELECTRON MICROSCOPY (2.82 Å) Cite: Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
7R8W	Crystal Structure of the LNK SH2 Domain in Complex with a JAK2 pY813 Phosphopeptide Descriptor: JAK2 pY813 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
7R8X	Crystal Structure of the LNK SH2 Domain in Complex with an EPOR pY454 Phosphopeptide Descriptor: EPOR pY454 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
7R8D	The structure of human ABCG1 E242Q with cholesterol Descriptor: CHOLESTEROL, Isoform 4 of ATP-binding cassette sub-family G member 1 Authors: Sun, Y, Li, X, Long, T. Deposit date: 2021-06-26 Release date: 2021-09-08 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
7R8A	The structure of human ABCG5/ABCG8 purified from mammalian cells Descriptor: 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... Authors: Sun, Y, Li, X, Long, T. Deposit date: 2021-06-26 Release date: 2021-09-08 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021

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