PDB: 957 resultsInfo pagesStatus searchChemie searchBIRD

---

4MNE	Crystal structure of the BRAF:MEK1 complex Descriptor: 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G. Deposit date: 2013-09-10 Release date: 2014-06-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8483 Å) Cite: Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling. Cancer Cell, 26, 2014
4LQW	Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin Descriptor: Capsid protein p24, E3 SUMO-protein ligase RanBP2 Authors: Price, A.J, James, L.C. Deposit date: 2013-07-19 Release date: 2013-08-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358. Retrovirology, 10, 2013
4LOQ	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate) Descriptor: 1,2-ETHANEDIOL, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, Mitogen-activated protein kinase 14, ... Authors: Chaikuad, A, DeNicola, G.F, Yue, W.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2013-07-13 Release date: 2013-08-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.319 Å) Cite: Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1. Nat.Struct.Mol.Biol., 20, 2013
4LOP	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form) Descriptor: 1,2-ETHANEDIOL, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, L(+)-TARTARIC ACID, ... Authors: Chaikuad, A, DeNicola, G.F, Krojer, T, Allerston, C.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2013-07-13 Release date: 2013-08-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.049 Å) Cite: Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1. Nat.Struct.Mol.Biol., 20, 2013
4LOO	Structural basis of autoactivation of p38 alpha induced by TAB1 (Monoclinic crystal form) Descriptor: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Authors: Chaikuad, A, DeNicola, G.F, Krojer, T, Allerston, C.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2013-07-13 Release date: 2013-08-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1. Nat.Struct.Mol.Biol., 20, 2013
4LMN	Crystal Structure of MEK1 kinase bound to GDC0973 Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Ultsch, M.H. Deposit date: 2013-07-10 Release date: 2013-08-07 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature, 501, 2013
4L8M	Human p38 MAP kinase in complex with a Dibenzoxepinone Descriptor: Mitogen-activated protein kinase 14, N-[2-fluoro-5-({9-[2-(morpholin-4-yl)ethoxy]-11-oxo-6,11-dihydrodibenzo[b,e]oxepin-3-yl}amino)phenyl]benzamide, octyl beta-D-glucopyranoside Authors: Richters, A, Mayer-Wrangowski, S.C, Gruetter, C, Rauh, D. Deposit date: 2013-06-17 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood. J.Med.Chem., 56, 2013
4KKH	The crystal structure of inhibitor-bound JNK3 Descriptor: Mitogen-activated protein kinase 10, cyclopropyl[(3R)-3-({4-[6-hydroxy-2-(naphthalen-2-yl)-1H-benzimidazol-1-yl]pyrimidin-2-yl}amino)piperidin-1-yl]methanone Authors: Han, B.G, Shim, M.B, Ahn, H.C. Deposit date: 2013-05-06 Release date: 2014-05-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: The crystal structure of AMP, apo, and inhibitor-bound JNK3 To be Published
4KKG	Crystal structure of apo and AMP-bound JNK3 Descriptor: Mitogen-activated protein kinase 10 Authors: Han, B.G, Shim, M.B, Ahn, H.C. Deposit date: 2013-05-06 Release date: 2014-05-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: crystal structure of apo and AMP-bound JNK3 To be Published
4KKE	The crystal structure of AMP-bound JNK3 Descriptor: ADENOSINE MONOPHOSPHATE, Mitogen-activated protein kinase 10 Authors: Han, B.G, Shim, M.B, Ahn, H.C. Deposit date: 2013-05-06 Release date: 2014-05-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The crystal structure of AMP-bound JNK3 To be Published
4KIQ	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with ETHYL 6-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)CARBAMOYL)-1H-INDOLE-1-CARBOXYLATE Descriptor: Mitogen-activated protein kinase 14, ethyl 6-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]carbamoyl}-1H-indole-1-carboxylate Authors: Sack, J.S, Tokarski, J.S. Deposit date: 2013-05-02 Release date: 2013-06-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode Bioorg.Med.Chem.Lett., 23, 2013
4KIP	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 2-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXAMIDE Descriptor: 2-(2-chlorophenyl)-N-[5-(cyclopropylcarbamoyl)-2-methylphenyl]-1,3-thiazole-5-carboxamide, Mitogen-activated protein kinase 14 Authors: Sack, J.S, Tokarski, J.S. Deposit date: 2013-05-02 Release date: 2013-06-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.27 Å) Cite: The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode Bioorg.Med.Chem.Lett., 23, 2013
4KIN	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE Descriptor: 5-(2-chlorophenyl)-N-[5-(cyclopropylcarbamoyl)-2-methylphenyl]thiophene-2-carboxamide, Mitogen-activated protein kinase 14 Authors: Sack, J.S, Tokarski, J.S. Deposit date: 2013-05-02 Release date: 2013-06-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.97 Å) Cite: The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode Bioorg.Med.Chem.Lett., 23, 2013
4KA3	Structure of MAP kinase in complex with a docking peptide Descriptor: Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Authors: Xin, F.J, Wu, J.W. Deposit date: 2013-04-22 Release date: 2013-06-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.707 Å) Cite: Crystal structure of the p38 alpha MAP kinase in complex with a docking peptide from TAB1 Sci China Life Sci, 56, 2013
4IZA	Structure of Dually Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain Descriptor: Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1 Authors: Mace, P.D, Robinson, H, Riedl, S.J. Deposit date: 2013-01-29 Release date: 2013-04-10 Last modified: 2013-04-24 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun, 4, 2013
4IZ7	Structure of Non-Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain Descriptor: Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1, SODIUM ION Authors: Mace, P.D, Robinson, H, Riedl, S.J. Deposit date: 2013-01-29 Release date: 2013-04-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun, 4, 2013
4IZ5	Structure of the complex between ERK2 phosphomimetic mutant and PEA-15 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1, ... Authors: Mace, P.D, Robinson, H, Riedl, S.J. Deposit date: 2013-01-29 Release date: 2013-04-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.19 Å) Cite: Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun, 4, 2013
4I5H	Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor Descriptor: Mitogen-activated protein kinase 1, N-{3-[2-(cyclopropylamino)quinazolin-6-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide Authors: Hari, S.B, Maly, D.J, Merritt, E.A. Deposit date: 2012-11-28 Release date: 2013-07-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Sequence determinants of a specific inactive protein kinase conformation. Chem.Biol., 20, 2013
4H3Q	Crystal structure of human ERK2 complexed with a MAPK docking peptide Descriptor: Dual specificity mitogen-activated protein kinase kinase 2, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Gogl, G, Toeroe, I, Remenyi, A. Deposit date: 2012-09-14 Release date: 2013-02-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase Acta Crystallogr.,Sect.D, 69, 2013
4H3P	Crystal structure of human ERK2 complexed with a MAPK docking peptide Descriptor: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1 Authors: Gogl, G, Toeroe, I, Remenyi, A. Deposit date: 2012-09-14 Release date: 2013-02-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase Acta Crystallogr.,Sect.D, 69, 2013
4H3B	Crystal Structure of JNK3 in Complex with SAB Peptide Descriptor: Mitogen-activated protein kinase 10, SH3 domain-binding protein 5 Authors: Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V. Deposit date: 2012-09-13 Release date: 2012-11-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases. Structure, 20, 2012
4H39	Crystal Structure of JNK3 in Complex with JIP1 Peptide Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 10 Authors: Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V. Deposit date: 2012-09-13 Release date: 2012-11-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.992 Å) Cite: Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases. Structure, 20, 2012
4H36	Crystal Structure of JNK3 in Complex with ATF2 Peptide Descriptor: Cyclic AMP-dependent transcription factor ATF-2, Mitogen-activated protein kinase 10 Authors: Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V. Deposit date: 2012-09-13 Release date: 2012-11-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases. Structure, 20, 2012
4GVA	ADP-bound form of the ERK2 kinase Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Mitogen-activated protein kinase 1 Authors: Pozharski, E, Zhang, J, Shapiro, P. Deposit date: 2012-08-30 Release date: 2012-09-12 Method: X-RAY DIFFRACTION (1.83 Å) Cite: ADP-bound form of the ERK2 kinase TO BE PUBLISHED
4GT3	ATP-bound form of the ERK2 kinase Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Pozharski, E, Zhang, J, Shapiro, P. Deposit date: 2012-08-28 Release date: 2012-09-12 Method: X-RAY DIFFRACTION (1.68 Å) Cite: ATP-bound form of the ERK2 kinase TO BE PUBLISHED

<17181920212223242526272829303132>