4KIP

Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 2-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXAMIDE

Summary for 4KIP

• Entry DOI: 10.2210/pdb4kip/pdb
• Related: 4KIN 4KIQ
• Descriptor: Mitogen-activated protein kinase 14, 2-(2-chlorophenyl)-N-[5-(cyclopropylcarbamoyl)-2-methylphenyl]-1,3-thiazole-5-carboxamide (3 entities in total)
• Functional Keywords: serine/threonine-protein kinase, kinase, transferase, p38 map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q16539
• Total number of polymer chains: 2
• Total formula weight: 85033.82

Authors

Sack, J.S.,Tokarski, J.S. (deposition date: 2013-05-02, release date: 2013-06-12, Last modification date: 2024-02-28)

• Primary citation: Wrobleski, S.T.,Lin, S.,Murali Dhar, T.G.,Dyckman, A.J.,Li, T.,Pitt, S.,Zhang, R.,Fan, Y.,Doweyko, A.M.,Tokarski, J.S.,Kish, K.F.,Kiefer, S.E.,Sack, J.S.,Newitt, J.A.,Witmer, M.R.,McKinnon, M.,Barrish, J.C.,Dodd, J.H.,Schieven, G.L.,Leftheris, K.; The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode; Bioorg.Med.Chem.Lett., 23:4120-4126, 2013; PubMed: 23746475; DOI: 10.1016/j.bmcl.2013.05.047

Experimental method

X-RAY DIFFRACTION (2.27 Å)