PDB: 2596 resultsInfo pagesStatus searchChemie searchBIRD

---

5X9O	Crystal structure of the BCL6 BTB domain in complex with Compound 1a Descriptor: 1,2-ETHANEDIOL, 5-[(2-chloranyl-4-nitro-phenyl)amino]-1,3-dihydrobenzimidazol-2-one, B-cell lymphoma 6 protein, ... Authors: Sogabe, S, Ida, K, Lane, W, Snell, G. Deposit date: 2017-03-08 Release date: 2017-08-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25, 2017
8JU9	Molecular mechanism of the one-component regulator RccR on bacterial metabolism and virulence Descriptor: 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 2-KETO-DEOXY-GALACTOSE, DI(HYDROXYETHYL)ETHER, ... Authors: Rui, B, Yibo, Z. Deposit date: 2023-06-25 Release date: 2024-01-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular mechanism of the one-component regulator RccR on bacterial metabolism and virulence. Nucleic Acids Res., 52, 2024
5X9P	Crystal structure of the BCL6 BTB domain in complex with Compound 5 Descriptor: 3-[[4-chloranyl-2-nitro-5-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)amino]phenyl]amino]propanoic acid, B-cell lymphoma 6 protein Authors: Sogabe, S, Ida, K, Lane, W, Snell, G. Deposit date: 2017-03-08 Release date: 2017-08-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25, 2017
4L9J	Crystal structure of S. aureus MepR in DNA-binding conformation Descriptor: MepR Authors: Birukou, I, Brennan, R.G. Deposit date: 2013-06-18 Release date: 2013-09-11 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (3.45 Å) Cite: The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus. MBio, 4, 2013
4L9V	Crystal structure of Se-Met derivative MepR F27L mutant from multidrug resistant S. aureus clinical isolate Descriptor: MepR Authors: Birukou, I, Brennan, R.G. Deposit date: 2013-06-18 Release date: 2013-09-11 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.374 Å) Cite: The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus. MBio, 4, 2013
1GXR	WD40 Region of Human Groucho/TLE1 Descriptor: CALCIUM ION, TRANSDUCIN-LIKE ENHANCER PROTEIN 1 Authors: Pearl, L.H, Roe, S.M, Pickles, L.M. Deposit date: 2002-04-10 Release date: 2002-06-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Crystal Structure of the C-Terminal Wd40 Repeat Domain of the Human Groucho/Tle1 Transcriptional Corepressor Structure, 10, 2002
1MYL	SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY Descriptor: ARC REPRESSOR Authors: Schildbach, J.F, Waldburger, C.D, Sauer, R.T. Deposit date: 1994-10-06 Release date: 1995-01-26 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Are buried salt bridges important for protein stability and conformational specificity? Nat.Struct.Biol., 2, 1995
2KC9	Structure of E. coli toxin RelE (R81A/R83A) mutant in the free state Descriptor: Toxin relE Authors: Li, G, Zhang, Y, Inouye, M, Ikura, M. Deposit date: 2008-12-17 Release date: 2009-03-17 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site. J.Biol.Chem., 284, 2009
3BR0	Crystal Structure of the Complex of Malachite Green Bound to QacR(E120Q), a Mutant of a Multidrug Binding Transcriptional Repressor Descriptor: HTH-type transcriptional regulator qacR, IMIDAZOLE, MALACHITE GREEN, ... Authors: Brooks, B.E. Deposit date: 2007-12-20 Release date: 2008-12-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Formal electrostatic interactions do not govern QacR-cation affinity To be Published
3BQZ	Crystal Structure of the Complex of Malachite Green Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor Descriptor: HTH-type transcriptional regulator qacR, IMIDAZOLE, MALACHITE GREEN, ... Authors: Brooks, B.E. Deposit date: 2007-12-20 Release date: 2008-12-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Formal electrostatic interactions do not govern QacR-cation affinity To be Published
1QTG	AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR Descriptor: Transcriptional repressor arc Authors: Cordes, M.H.J, Walsh, N.P, McKnight, C.J, Sauer, R.T. Deposit date: 1999-06-27 Release date: 1999-07-12 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Evolution of a protein fold in vitro. Science, 284, 1999
1XA7	Crystal structure of the benzylpenicillin-acylated BlaR1 sensor domain from Staphylococcus aureus Descriptor: OPEN FORM - PENICILLIN G, Regulatory protein BlaR1 Authors: Wilke, M.S, Hills, T.L, Zhang, H.Z, Chambers, H.F, Strynadka, N.C. Deposit date: 2004-08-25 Release date: 2004-09-21 Last modified: 2018-10-24 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus. J.Biol.Chem., 279, 2004
3DEU	Crystal structure of transcription regulatory protein slyA from Salmonella typhimurium in complex with salicylate ligands Descriptor: 2-HYDROXYBENZOIC ACID, Transcriptional regulator slyA Authors: Le Trong, I, Brzovic, P.S, Fang, F.C, Libby, S.J, Stenkamp, R.E. Deposit date: 2008-06-10 Release date: 2008-06-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The Evolution of SlyA/RovA Transcription Factors from Repressors to Countersilencers in Enterobacteriaceae . Mbio, 10, 2019
4IVN	The Vibrio vulnificus NanR protein complexed with ManNAc-6P Descriptor: 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-mannopyranose, Transcriptional regulator Authors: Hwang, J, Kim, M.H. Deposit date: 2013-01-23 Release date: 2013-07-17 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR Proc.Natl.Acad.Sci.USA, 110, 2013
2MD5	Structure of uninhibited ETV6 ETS domain Descriptor: Transcription factor ETV6 Authors: De, S, Mcintosh, L.P, Chan, A.C, Coyne, H.J, Okon, M, Graves, B.J, Murphy, M.E. Deposit date: 2013-08-29 Release date: 2013-12-25 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6. J.Mol.Biol., 426, 2014
1GMG	ALANINE 31 PROLINE MUTANT OF ROP PROTEIN, MONOCLINIC FORM Descriptor: REGULATORY PROTEIN ROP Authors: Glykos, N.M, Kokkinidis, M. Deposit date: 2001-09-13 Release date: 2002-09-12 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure Determination of a Small Protein Through a 23-Dimensional Molecular-Replacement Search. Acta Crystallogr.,Sect.D, 59, 2003
7RCU	Synthetic Max homodimer mimic in complex with DNA Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2-(2,5-dioxopyrrolidin-1-yl)acetamide, ACETAMIDE, ... Authors: Speltz, T, Qiao, Z, Shangguan, S, Fanning, S, Greene, J, Moellering, R. Deposit date: 2021-07-08 Release date: 2022-09-14 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat.Biotechnol., 41, 2023
2Z4J	Crystal structure of AR LBD with SHP peptide NR Box 2 Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Nuclear receptor 0B2 Authors: Jouravel, N, Fletterick, R.J. Deposit date: 2007-06-19 Release date: 2007-12-04 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Interaction between the androgen receptor and a segment of its corepressor SHP Acta Crystallogr.,Sect.D, 63, 2007
3BPX	Crystal Structure of MarR Descriptor: 2-HYDROXYBENZOIC ACID, SODIUM ION, Transcriptional regulator Authors: Saridakis, V, Shahinas, D, Xu, X, Christendat, D. Deposit date: 2007-12-19 Release date: 2008-05-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural insight on the mechanism of regulation of the MarR family of proteins: high-resolution crystal structure of a transcriptional repressor from Methanobacterium thermoautotrophicum. J.Mol.Biol., 377, 2008
4LLL	Crystal structure of S. aureus MepR-DNA complex Descriptor: MepR, Palindromized mepR operator sequence Authors: Birukou, I, Brennan, R.G. Deposit date: 2013-07-09 Release date: 2014-05-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.036 Å) Cite: Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR. Nucleic Acids Res., 42, 2014
4LLN	Crystal structure of S. aureus MepR-DNA complex Descriptor: MepR, Palindromized mepR operator sequence Authors: Birukou, I, Brennan, R.G. Deposit date: 2013-07-09 Release date: 2014-05-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.842 Å) Cite: Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR. Nucleic Acids Res., 42, 2014
4HQM	The crystal structure of QsrR-menadione complex Descriptor: 2-methylnaphthalene-1,4-diol, QsrR protein Authors: Ji, Q, Zhang, L, Jones, M.B, Sun, F, Deng, X, Liang, H, Brugarolas, P, Gao, N, Peterson, S.N, Lan, L, Bae, T, He, C. Deposit date: 2012-10-25 Release date: 2013-03-06 Last modified: 2013-05-22 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc.Natl.Acad.Sci.USA, 110, 2013
4HQE	The crystal structure of QsrR-DNA complex Descriptor: DNA (5'-D(*AP*GP*TP*AP*TP*AP*AP*TP*TP*AP*TP*TP*AP*TP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*TP*AP*AP*TP*AP*AP*TP*TP*AP*TP*AP*CP*T)-3'), Transcriptional regulator QsrR Authors: He, C, Ji, Q, Zhang, L. Deposit date: 2012-10-25 Release date: 2013-03-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.299 Å) Cite: Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc.Natl.Acad.Sci.USA, 110, 2013
1QX8	Crystal structure of a five-residue deletion mutant of the Rop protein Descriptor: Regulatory protein ROP Authors: Glykos, N.M, Vlassi, M, Papanikolaou, Y, Kotsifaki, D, Cesareni, G, Kokkinidis, M. Deposit date: 2003-09-04 Release date: 2004-09-28 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Loopless Rop: structure and dynamics of an engineered homotetrameric variant of the repressor of primer protein. Biochemistry, 45, 2006
6AZ6	Streptococcus agalactiae GntR Descriptor: GntR family transcriptional regulator Authors: Pellock, S.J, Redinbo, M.R. Deposit date: 2017-09-10 Release date: 2017-12-20 Last modified: 2019-12-04 Method: X-RAY DIFFRACTION (1.909 Å) Cite: Structural basis for the regulation of beta-glucuronidase expression by human gut Enterobacteriaceae. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

<14151617181920212223242526272829>