Structure of uninhibited ETV6 ETS domain

Summary for 2MD5

Related2LF8 2LF7 4MHG
DescriptorTranscription factor ETV6 (1 entity in total)
Functional Keywordsprotein, auto-inhibition, transcription
Biological sourceMus musculus (mouse)
Cellular locationNucleus (By similarity) P97360
Total number of polymer chains1
Total molecular weight12450.35
De, S.,Mcintosh, L.P.,Chan, A.C.,Coyne, H.J.,Okon, M.,Graves, B.J.,Murphy, M.E. (deposition date: 2013-08-29, release date: 2013-12-25, Last modification date: 2014-04-02)
Primary citation
De, S.,Chan, A.C.,Coyne, H.J.,Bhachech, N.,Hermsdorf, U.,Okon, M.,Murphy, M.E.,Graves, B.J.,McIntosh, L.P.
Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6.
J.Mol.Biol., 426:1390-1406, 2014
PubMed: 24333486 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2013.11.031
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers404.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 2md5
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Molmil generated image of 2md5
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Molmil generated image of 2md5
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