3DEG
 
 | | Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP | | Descriptor: | 30S RNA helix 14, 30S RNA helix 8, 30S ribosomal protein S12, ... | | Authors: | Connell, S.R, Topf, M, Qin, Y, Wilson, D.N, Mielke, T, Fucini, P, Nierhaus, K.H, Spahn, C.M.T. | | Deposit date: | 2008-06-10 | | Release date: | 2008-08-19 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (10.9 Å) | | Cite: | A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
Nat.Struct.Mol.Biol., 15, 2008
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3DNY
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3U6K
 | | Ef-tu (escherichia coli) in complex with nvp-ldk733 | | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Palestrant, D.J. | | Deposit date: | 2011-10-12 | | Release date: | 2012-02-08 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
J.Med.Chem., 54, 2011
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3U2Q
 | | EF-Tu (Escherichia coli) in complex with NVP-LFF571 | | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Palestrant, D.J. | | Deposit date: | 2011-10-04 | | Release date: | 2012-05-02 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Discovery of LFF571: an investigational agent for Clostridium difficile infection.
J.Med.Chem., 55, 2012
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3U6B
 | | Ef-tu (escherichia coli) in complex with nvp-ldi028 | | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Palestrant, D.J. | | Deposit date: | 2011-10-12 | | Release date: | 2012-02-08 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
J.Med.Chem., 54, 2011
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5OPD
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1SKQ
 | | The crystal structure of Sulfolobus solfataricus elongation factor 1-alpha in complex with magnesium and GDP | | Descriptor: | Elongation factor 1-alpha, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Vitagliano, L, Ruggiero, A, Masullo, M, Cantiello, P, Arcari, P, Zagari, A. | | Deposit date: | 2004-03-05 | | Release date: | 2004-07-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The crystal structure of Sulfolobus solfataricus elongation factor 1alpha in complex with magnesium and GDP.
Biochemistry, 43, 2004
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8RO0
 | | Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS') | | Descriptor: | Cell division cycle 5-like protein, Coiled-coil domain-containing protein 12, GCF C-terminal domain-containing protein, ... | | Authors: | Vorlaender, M.K, Rothe, P, Plaschka, C. | | Deposit date: | 2024-01-11 | | Release date: | 2024-08-07 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
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8RO1
 | | Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'') | | Descriptor: | CWF19-like protein 1 homolog, CWF19-like protein 2 homolog, Cell division cycle 5-like protein, ... | | Authors: | Vorlaender, M.K, Rothe, P, Plaschka, C. | | Deposit date: | 2024-01-11 | | Release date: | 2024-08-07 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
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8RO2
 | | Integrative Structure of the human intron lariat Spliceosome (ILS'') | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ATP-dependent RNA helicase DHX15, CWF19-like protein 1, ... | | Authors: | Rothe, P, Vorlaender, M.K, Plaschka, C. | | Deposit date: | 2024-01-11 | | Release date: | 2024-09-18 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
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1D8T
 | | CRYSTAL STRUCTURE OF ELONGATION FACTOR, TU (EF-TU-MGGDP) COMPLEXED WITH GE2270A, A THIAZOLYL PEPTIDE ANTIBIOTIC | | Descriptor: | ACETATE ION, ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Heffron, S.E, Jurnak, F. | | Deposit date: | 1999-10-25 | | Release date: | 2000-10-25 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure of an EF-TU Complex with a Thiazolyl Peptide Antibiotic Determined at 2.35 A Resolution: Atomic Basis for Ge2270A Inhibition of EF-TU.
Biochemistry, 39, 2000
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8RW1
 | | Structure of a yeast 48S-AUC preinitiation complex in closed conformation | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein L41-A, 40S ribosomal protein S12, ... | | Authors: | Villamayor-Belinchon, L, Sharma, P, Llacer, J.L, Hussain, T. | | Deposit date: | 2024-02-02 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structural basis of AUC codon discrimination during translation initiation in yeast.
Nucleic Acids Res., 52, 2024
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5OT7
 | | Elongation factor G-ribosome complex captures in the absence of inhibitors. | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Mace, K, Giudice, E, Chat, S, Gillet, R. | | Deposit date: | 2017-08-21 | | Release date: | 2018-02-14 | | Last modified: | 2018-04-11 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | The structure of an elongation factor G-ribosome complex captured in the absence of inhibitors.
Nucleic Acids Res., 46, 2018
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1U2R
 | | Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Elongation factor 2, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Jorgensen, R, Yates, S.P, Nilsson, J, Prentice, G.A, Teal, D.J, Merrill, A.R, Andersen, G.R. | | Deposit date: | 2004-07-20 | | Release date: | 2004-09-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae
J.Biol.Chem., 279, 2004
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6O85
 | | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic translation initiation factor 2 from Homo sapiens | | Descriptor: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, ... | | Authors: | Nguyen, H.C, Kenner, L.R, Frost, A.S. | | Deposit date: | 2019-03-08 | | Release date: | 2019-05-15 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science, 364, 2019
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6O81
 | | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation initiation factor 2 from Homo sapiens | | Descriptor: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, ... | | Authors: | Nguyen, H, Kenner, L, Frost, A. | | Deposit date: | 2019-03-08 | | Release date: | 2019-05-15 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science, 364, 2019
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6O9K
 | | 70S initiation complex | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | Authors: | Frank, J, Gonzalez Jr, R.L, kaledhonkar, S, Fu, Z, Caban, K, Li, W, Chen, B, Sun, M. | | Deposit date: | 2019-03-14 | | Release date: | 2019-05-29 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Late steps in bacterial translation initiation visualized using time-resolved cryo-EM.
Nature, 570, 2019
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1D2E
 | | CRYSTAL STRUCTURE OF MITOCHONDRIAL EF-TU IN COMPLEX WITH GDP | | Descriptor: | ELONGATION FACTOR TU (EF-TU), GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Andersen, G.R, Thirup, S, Spremulli, L.L, Nyborg, J. | | Deposit date: | 1999-09-23 | | Release date: | 1999-09-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | High resolution crystal structure of bovine mitochondrial EF-Tu in complex with GDP.
J.Mol.Biol., 297, 2000
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1TTT
 | | Phe-tRNA, elongation factoR EF-TU:GDPNP ternary complex | | Descriptor: | MAGNESIUM ION, OF ELONGATION FACTOR TU (EF-TU), PHENYLALANINE, ... | | Authors: | Nissen, P, Kjeldgaard, M, Thirup, S, Polekhina, G, Reshetnikova, L, Clark, B.F.C, Nyborg, J. | | Deposit date: | 1995-11-16 | | Release date: | 1996-12-23 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog.
Science, 270, 1995
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1TUI
 | | INTACT ELONGATION FACTOR TU IN COMPLEX WITH GDP | | Descriptor: | ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Polekhina, G, Thirup, S, Kjeldgaard, M, Nissen, P, Lippmann, C, Nyborg, J. | | Deposit date: | 1996-05-23 | | Release date: | 1997-06-05 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Helix unwinding in the effector region of elongation factor EF-Tu-GDP.
Structure, 4, 1996
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1DG1
 | | WHOLE, UNMODIFIED, EF-TU(ELONGATION FACTOR TU). | | Descriptor: | ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Abel, K, Yoder, M, Hilgenfeld, R, Jurnak, F. | | Deposit date: | 1999-11-22 | | Release date: | 1999-12-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | An alpha to beta conformational switch in EF-Tu.
Structure, 4, 1996
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1OB2
 | | E. coli elongation factor EF-Tu complexed with the antibiotic kirromycin, a GTP analog, and Phe-tRNA | | Descriptor: | ELONGATION FACTOR TU, KIRROMYCIN, MAGNESIUM ION, ... | | Authors: | Kristensen, O, Nissen, P, Nyborg, J. | | Deposit date: | 2003-01-24 | | Release date: | 2004-05-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Kirromycin Defines a Specific Domain Arrangement of Elongation Factor EF-TU
To be Published
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5O8W
 | | CRYSTAL STRUCTURE ANALYSIS OF THE YEAST ELONGATION FACTOR COMPLEX EEF1A:EEF1BA | | Descriptor: | Elongation factor 1-alpha, Elongation factor 1-beta, GLUTAMINE, ... | | Authors: | Wirth, C, Andersen, G.R, Hunte, C. | | Deposit date: | 2017-06-14 | | Release date: | 2017-08-23 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A.
J. Biol. Chem., 292, 2017
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5O9Z
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6O7K
 | | 30S initiation complex | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Frank, J, Gonzalez Jr, R.L, kaledhonkar, S, Fu, Z, Caban, K, Li, W, Chen, B, Sun, M. | | Deposit date: | 2019-03-08 | | Release date: | 2019-05-29 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Late steps in bacterial translation initiation visualized using time-resolved cryo-EM.
Nature, 570, 2019
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