3U6K

Ef-tu (escherichia coli) in complex with nvp-ldk733

Summary for 3U6K

Entry DOI	10.2210/pdb3u6k/pdb
Related	3U2Q 3U6B
Related PRD ID	PRD_001073
Descriptor	Elongation factor Tu 1, Thiocillin GE2270 analogue NVP-LDK733, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	translation factor-antibiotic complex, translation factor/antibiotic
Biological source	Escherichia coli
Cellular location	Cytoplasm: P0CE47 Secreted: Q7M0J8
Total number of polymer chains	4
Total formula weight	90471.24
Authors	Palestrant, D.J. (deposition date: 2011-10-12, release date: 2012-02-08, Last modification date: 2023-11-15)
Primary citation	LaMarche, M.J.,Leeds, J.A.,Amaral, K.,Brewer, J.T.,Bushell, S.M.,Dewhurst, J.M.,Dzink-Fox, J.,Gangl, E.,Goldovitz, J.,Jain, A.,Mullin, S.,Neckermann, G.,Osborne, C.,Palestrant, D.,Patane, M.A.,Rann, E.M.,Sachdeva, M.,Shao, J.,Tiamfook, S.,Whitehead, L.,Yu, D. Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids. J.Med.Chem., 54:8099-8109, 2011 Cited by PubMed: 21999529 DOI: 10.1021/jm200938f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation