3U2Q

EF-Tu (Escherichia coli) in complex with NVP-LFF571

Summary for 3U2Q

Entry DOI	10.2210/pdb3u2q/pdb
Related	3U6B 3U6K
Related PRD ID	PRD_001072
Descriptor	Elongation factor Tu 1, Thiocillin GE2270 analogue NVP-LFF571, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	translation factor-antibiotic complex, translation factor/antibiotic
Biological source	Escherichia coli
Cellular location	Cytoplasm: P0CE47 Secreted: Q7M0J8
Total number of polymer chains	2
Total formula weight	45335.74
Authors	Palestrant, D.J. (deposition date: 2011-10-04, release date: 2012-05-02, Last modification date: 2023-11-15)
Primary citation	LaMarche, M.J.,Leeds, J.A.,Amaral, A.,Brewer, J.T.,Bushell, S.M.,Deng, G.,Dewhurst, J.M.,Ding, J.,Dzink-Fox, J.,Gamber, G.,Jain, A.,Lee, K.,Lee, L.,Lister, T.,McKenney, D.,Mullin, S.,Osborne, C.,Palestrant, D.,Patane, M.A.,Rann, E.M.,Sachdeva, M.,Shao, J.,Tiamfook, S.,Trzasko, A.,Whitehead, L.,Yifru, A.,Yu, D.,Yan, W.,Zhu, Q. Discovery of LFF571: an investigational agent for Clostridium difficile infection. J.Med.Chem., 55:2376-2387, 2012 Cited by PubMed: 22315981 DOI: 10.1021/jm201685h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation