6RAY
| D. melanogaster CMG-DNA, State 2A | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, AT18545p, ... | Authors: | Eickhoff, P, Martino, F, Costa, A. | Deposit date: | 2019-04-08 | Release date: | 2019-09-11 | Last modified: | 2019-09-18 | Method: | ELECTRON MICROSCOPY (4.28 Å) | Cite: | Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome. Cell Rep, 28, 2019
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7W68
| human single hexameric Mcm2-7 complex | Descriptor: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | Authors: | Xu, N.N, Lin, Q.P, Liu, C.D, Tian, H.L, Xiang, Y, Zhu, G. | Deposit date: | 2021-12-01 | Release date: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | human single hexameric Mcm2-7 complex To Be Published
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7WI7
| Crystal structure of human MCM8/9 complex | Descriptor: | DNA helicase MCM8, DNA helicase MCM9, ZINC ION | Authors: | Li, J, Liu, Y. | Deposit date: | 2022-01-03 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (6.6 Å) | Cite: | Crystal structure of human MCM8/9 complex To Be Published
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6SKL
| Cryo-EM structure of the CMG Fork Protection Complex at a replication fork - Conformation 1 | Descriptor: | Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA fork, ... | Authors: | Yeeles, J, Baretic, D, Jenkyn-Bedford, M. | Deposit date: | 2019-08-16 | Release date: | 2020-05-06 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork. Mol.Cell, 78, 2020
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7W1Y
| Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (49-MER), ... | Authors: | Li, J, Dong, J, Dang, S, Zhai, Y. | Deposit date: | 2021-11-21 | Release date: | 2023-02-08 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | The human pre-replication complex is an open complex. Cell, 186, 2023
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3JC7
| Structure of the eukaryotic replicative CMG helicase and pumpjack motion | Descriptor: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | Authors: | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | Deposit date: | 2015-11-24 | Release date: | 2016-02-10 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat.Struct.Mol.Biol., 23, 2016
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6U0M
| Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (15-MER), ... | Authors: | Yuan, Z, Georgescu, R, Bai, L, Zhang, D, O'Donnell, M, Li, H. | Deposit date: | 2019-08-14 | Release date: | 2020-03-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | DNA unwinding mechanism of a eukaryotic replicative CMG helicase. Nat Commun, 11, 2020
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6SKO
| Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork - conformation 2 MCM CTD:ssDNA | Descriptor: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | Authors: | Yeeles, J, Baretic, D, Jenkyn-Bedford, M. | Deposit date: | 2019-08-16 | Release date: | 2020-05-06 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork. Mol.Cell, 78, 2020
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6WGF
| Atomic model of mutant Mcm2-7 hexamer with Mcm6 WHD truncation | Descriptor: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
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3JA8
| Cryo-EM structure of the MCM2-7 double hexamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Minichromosome Maintenance 2, Minichromosome Maintenance 3, ... | Authors: | Li, N, Zhai, Y, Zhang, Y, Li, W, Yang, M, Lei, J, Tye, B.K, Gao, N. | Deposit date: | 2015-05-09 | Release date: | 2015-08-05 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of the eukaryotic MCM complex at 3.8 angstrom Nature, 524, 2015
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3JC5
| Structure of the eukaryotic replicative CMG helicase and pumpjack motion | Descriptor: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | Authors: | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | Deposit date: | 2015-11-24 | Release date: | 2016-02-10 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat.Struct.Mol.Biol., 23, 2016
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7W8G
| Cryo-EM structure of MCM double hexamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... | Authors: | Cheng, J, Li, N, Tye, B, Zhai, Y, Gao, N. | Deposit date: | 2021-12-07 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase. Nat Commun, 13, 2022
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3JC6
| Structure of the eukaryotic replicative CMG helicase and pumpjack motion | Descriptor: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | Authors: | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | Deposit date: | 2015-11-24 | Release date: | 2016-02-10 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat.Struct.Mol.Biol., 23, 2016
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8S92
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8S94
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8S91
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7P30
| 3.0 A resolution structure of a DNA-loaded MCM double hexamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (53-MER), ... | Authors: | Greiwe, J.F, Miller, T.C.R, Martino, F, Costa, A. | Deposit date: | 2021-07-06 | Release date: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nat.Struct.Mol.Biol., 29, 2022
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8Q6P
| X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor mcm2, DNA replication licensing factor mcm4-B, ... | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | Deposit date: | 2023-08-14 | Release date: | 2023-10-18 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation. Mol.Cell, 83, 2023
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8Q6O
| X. laevis CMG dimer bound to dimeric DONSON - without ATPase | Descriptor: | Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | Deposit date: | 2023-08-14 | Release date: | 2023-10-18 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation. Mol.Cell, 83, 2023
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8OUW
| Cryo-EM structure of CMG helicase bound to TIM-1/TIPN-1 and homodimeric DNSN-1 on fork DNA (Caenorhabditis elegans) | Descriptor: | Cell division control protein 45 homolog, DNA Lagging Strand Template, DNA Leading Strand Template, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Labib, K.P.M. | Deposit date: | 2023-04-25 | Release date: | 2023-08-16 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Science, 381, 2023
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8EAI
| SsoMCM hexamer bound to Mg/ADP-BeFx and 16-mer oligo-dT. Class 2 | Descriptor: | 16-mer oligo-dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAH
| SsoMCM hexamer bound to Mg/ADP-BeFx and 16-mer oligo-dT. Class 1 | Descriptor: | 16-mer oligo-dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAJ
| SsoMCM hexamer bound to Mg/ADP-BeFx and 46-mer DNA strand. Class 1 | Descriptor: | 46-mer DNA strand, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAL
| SsoMCM hexamer bound to Mg/ADP-BeFx and DNA. Class 1. Merged particles from datasets with 3 different DNA entities | Descriptor: | DNA, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (2.34 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAF
| SsoMCM hexamer bound to Mg/ADP-BeFx and 12-mer oligo-dT. Class 1 | Descriptor: | 12-mer oligo dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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