4J8C
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4J9V
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![BU of 4j9v by Molmil](/molmil-images/mine/4j9v) | Crystal Structure of the TrkA Gating ring bound to ATP-gamma-S | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Potassium uptake protein TrkA, ... | Authors: | Huang, H, Levin, E.J, Jin, X, Cao, Y, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2013-02-17 | Release date: | 2013-04-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.051 Å) | Cite: | Gating of the TrkH ion channel by its associated RCK protein TrkA. Nature, 496, 2013
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4JBO
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![BU of 4jbo by Molmil](/molmil-images/mine/4jbo) | Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules | Descriptor: | 1-(4-{2-[(6-{4-[2-(dimethylamino)ethoxy]phenyl}furo[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea, Aurora kinase A | Authors: | Wu, J.S, Leou, J.S, Peng, Y.H, Hsueh, C.C, Hsieh, H.P, Wu, S.Y. | Deposit date: | 2013-02-20 | Release date: | 2013-06-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.493 Å) | Cite: | Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JBU
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![BU of 4jbu by Molmil](/molmil-images/mine/4jbu) | 1.65A structure of the T3SS tip protein LcrV (G28-D322, C273S) from Yersinia pestis | Descriptor: | TETRAETHYLENE GLYCOL, Virulence-associated V antigen | Authors: | Lovell, S, Chaudhury, S, Battaile, K.P, Plano, G, De Guzman, R.N. | Deposit date: | 2013-02-20 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure of the Yersinia pestis tip protein LcrV refined to 1.65A resolution Acta Crystallogr.,Sect.F, 69, 2013
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4JG0
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![BU of 4jg0 by Molmil](/molmil-images/mine/4jg0) | Structure of phosphoserine/threonine (pSTAb) scaffold bound to pSer peptide | Descriptor: | Fab heavy chain, Fab light chain, PROPANOIC ACID, ... | Authors: | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | Deposit date: | 2013-02-28 | Release date: | 2013-08-28 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Nature-inspired design of motif-specific antibody scaffolds. Nat.Biotechnol., 31, 2013
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4JD5
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![BU of 4jd5 by Molmil](/molmil-images/mine/4jd5) | Crystal Structure of Benzoylformate Decarboxylase Mutant L403E | Descriptor: | 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ... | Authors: | Novak, W.R.P, Andrews, F.H, Tom, A.R, Gunderman, P.R, McLeish, M.J. | Deposit date: | 2013-02-23 | Release date: | 2013-05-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate. Biochemistry, 52, 2013
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4JEG
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![BU of 4jeg by Molmil](/molmil-images/mine/4jeg) | Crystal Structure of Monobody CS1/SHP2 C-SH2 Domain Complex | Descriptor: | Monobody CS1, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Sha, F, Koide, S. | Deposit date: | 2013-02-26 | Release date: | 2013-08-28 | Last modified: | 2014-03-12 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc.Natl.Acad.Sci.USA, 110, 2013
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3EVS
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![BU of 3evs by Molmil](/molmil-images/mine/3evs) | Crystal structure of the GDF-5:BMP receptor IB complex. | Descriptor: | Bone morphogenetic protein receptor type-1B, Growth/differentiation factor 5 | Authors: | Kotzsch, A, Mueller, T.D. | Deposit date: | 2008-10-13 | Release date: | 2009-03-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. Embo J., 28, 2009
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3EW3
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![BU of 3ew3 by Molmil](/molmil-images/mine/3ew3) | the 1:2 complex between a Nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor | Descriptor: | Prolactin, Prolactin receptor | Authors: | Broutin, I, Jomain, J.B, England, P, Goffin, V. | Deposit date: | 2008-10-14 | Release date: | 2009-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2. J.Biol.Chem., 285, 2010
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4JN9
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![BU of 4jn9 by Molmil](/molmil-images/mine/4jn9) | Crystal structure of the DepH | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DepH, ... | Authors: | Li, J, Wang, C, Zhang, Z.M, Zhou, J.H, Cheng, E. | Deposit date: | 2013-03-14 | Release date: | 2014-04-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis. Sci Rep, 4, 2014
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3EY6
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![BU of 3ey6 by Molmil](/molmil-images/mine/3ey6) | Crystal structure of the FK506-binding domain of human FKBP38 | Descriptor: | FK506-binding protein 8 | Authors: | Parthier, C, Maestre-Martinez, M, Neumann, P, Edlich, F, Fischer, G, Luecke, C, Stubbs, M.T. | Deposit date: | 2008-10-19 | Release date: | 2009-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding. J.Mol.Recognit., 24, 2011
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4IBK
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![BU of 4ibk by Molmil](/molmil-images/mine/4ibk) | Ebola virus VP35 bound to small molecule | Descriptor: | 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | Deposit date: | 2012-12-08 | Release date: | 2014-03-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IHV
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4ICI
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4IDZ
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![BU of 4idz by Molmil](/molmil-images/mine/4idz) | Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-oxalylglycine (NOG) | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase FTO, GLYCEROL, N-OXALYLGLYCINE, ... | Authors: | Aik, W.S, McDonough, M.A, Schofield, C.J. | Deposit date: | 2012-12-13 | Release date: | 2013-04-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Structural basis for inhibition of the fat mass and obesity associated protein (FTO) J.Med.Chem., 56, 2013
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4IEB
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![BU of 4ieb by Molmil](/molmil-images/mine/4ieb) | Crystal Structure of a Gly128Met mutant of the toxoplasma CDPK, TGME49_101440 | Descriptor: | CALCIUM ION, Calmodulin-domain protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Wernimont, A.K, Artz, J.D, El Bakkouri, M, Schapira, M, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | Deposit date: | 2012-12-13 | Release date: | 2013-12-25 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal Structure of a Gly128Met mutant of the toxoplasma CDPK, TGME49_101440 To be Published
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4ILT
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![BU of 4ilt by Molmil](/molmil-images/mine/4ilt) | Structure of the dioxygenase domain of SACTE_2871, a novel dioxygenase carbohydrate-binding protein fusion from the cellulolytic bacterium Streptomyces sp. SirexAA-E | Descriptor: | CHLORIDE ION, FE (III) ION, Intradiol ring-cleavage dioxygenase | Authors: | Bianchetti, C.M, Takasuka, T.E, Bergeman, L.F, Harmann, C.H, Fox, B.G. | Deposit date: | 2012-12-31 | Release date: | 2013-05-15 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Fusion of Dioxygenase and Lignin-binding Domains in a Novel Secreted Enzyme from Cellulolytic Streptomyces sp. SirexAA-E. J.Biol.Chem., 288, 2013
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4IHP
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![BU of 4ihp by Molmil](/molmil-images/mine/4ihp) | Crystal structure of TgCDPK1 with inhibitor bound | Descriptor: | 1-tert-butyl-3-(3-chlorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1, UNKNOWN ATOM OR ION | Authors: | El Bakkouri, M, Tempel, W, Crandall, I.E, Massad, T, Loppnau, P, Graslund, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Kain, C.K, Shokat, K.M, Sibley, L.D, Hui, R, Structural Genomics Consortium (SGC) | Deposit date: | 2012-12-19 | Release date: | 2014-01-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Crystal structure of TgCDPK1 with inhibitor bound TO BE PUBLISHED
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4IJ2
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![BU of 4ij2 by Molmil](/molmil-images/mine/4ij2) | Human methemoglobin in complex with the second and third NEAT domains of IsdH from Staphylococcus aureus | Descriptor: | Hemoglobin subunit alpha, Hemoglobin subunit beta, Iron-regulated surface determinant protein H, ... | Authors: | Dickson, C.F, Jacques, D.A, Guss, J.M, Gell, D.A. | Deposit date: | 2012-12-21 | Release date: | 2013-12-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (4.24 Å) | Cite: | Structure of the Hemoglobin-IsdH Complex Reveals the Molecular Basis of Iron Capture by Staphylococcus aureus J.Biol.Chem., 289, 2014
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4IOQ
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4IBQ
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![BU of 4ibq by Molmil](/molmil-images/mine/4ibq) | Human p53 core domain with hot spot mutation R273C | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Cellular tumor antigen p53, ... | Authors: | Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. | Deposit date: | 2012-12-09 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IBC
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![BU of 4ibc by Molmil](/molmil-images/mine/4ibc) | Ebola virus VP35 bound to small molecule | Descriptor: | DIMETHYL SULFOXIDE, Polymerase cofactor VP35, {4-[(2R)-3-(2-chlorobenzoyl)-2-(2-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid | Authors: | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | Deposit date: | 2012-12-08 | Release date: | 2014-03-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.745 Å) | Cite: | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBS
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![BU of 4ibs by Molmil](/molmil-images/mine/4ibs) | Human p53 core domain with hot spot mutation R273H (form I) | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, ZINC ION | Authors: | Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. | Deposit date: | 2012-12-09 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IHH
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![BU of 4ihh by Molmil](/molmil-images/mine/4ihh) | Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4'-PHOSPHOPANTETHEINE, Acyl carrier protein, ... | Authors: | Masoudi, A, Raetz, C.R.H, Pemble, C.W. | Deposit date: | 2012-12-18 | Release date: | 2013-11-13 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.132 Å) | Cite: | Chasing acyl carrier protein through a catalytic cycle of lipid A production. Nature, 505, 2014
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4IJE
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![BU of 4ije by Molmil](/molmil-images/mine/4ije) | Crystal structure of the Zaire ebolavirus VP35 interferon inhibitory domain R312A/K319A/R322A mutant | Descriptor: | PHOSPHATE ION, POTASSIUM ION, Polymerase cofactor VP35, ... | Authors: | Binning, J.B, Wang, T, Leung, D.W, Xu, W, Borek, D, Amarasinghe, G.K. | Deposit date: | 2012-12-21 | Release date: | 2013-10-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.899 Å) | Cite: | Development of RNA Aptamers Targeting Ebola Virus VP35. Biochemistry, 52, 2013
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