4IDZ
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-oxalylglycine (NOG)
Summary for 4IDZ
Entry DOI | 10.2210/pdb4idz/pdb |
Related | 3LFM 4IE0 4IE4 4IE5 4IE6 4IE7 |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE, GLYCEROL, ... (5 entities in total) |
Functional Keywords | double-stranded beta helix, jelly-roll motif, oxidoreductase, dioxygenase, nucleic acid demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q9C0B1 |
Total number of polymer chains | 1 |
Total formula weight | 57120.92 |
Authors | Aik, W.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2012-12-13, release date: 2013-04-03, Last modification date: 2023-11-08) |
Primary citation | Aik, W.S.,Demetriades, M.,Hamdan, M.K.K.,Bagg, E.A.L.,Yeoh, K.K.,Lejeune, C.,Zhang, Z.,McDonough, M.A.,Schofield, C.J. Structural basis for inhibition of the fat mass and obesity associated protein (FTO) J.Med.Chem., 56:3680-3688, 2013 Cited by PubMed: 23547775DOI: 10.1021/jm400193d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
Download full validation report