Crystal structure of the FK506-binding domain of human FKBP38

Summary for 3EY6

Related2F2D 2AWG
DescriptorFK506-binding protein 8 (2 entities in total)
Functional Keywordsbeta half-barrel, ppiase, immunophilin, apoptosis, host-virus interaction, isomerase, membrane, mitochondrion, phosphoprotein, rotamase, tpr repeat, transmembrane
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion . Isoform 1: Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side . Isoform 3: Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side  Q14318
Total number of polymer chains1
Total molecular weight13067.96
Parthier, C.,Maestre-Martinez, M.,Neumann, P.,Edlich, F.,Fischer, G.,Luecke, C.,Stubbs, M.T. (deposition date: 2008-10-19, release date: 2009-10-27, Last modification date: 2017-10-25)
Primary citation
Maestre-Martinez, M.,Haupt, K.,Edlich, F.,Neumann, P.,Parthier, C.,Stubbs, M.T.,Fischer, G.,Luecke, C.
A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding.
J.Mol.Recognit., 24:23-34, 2011
PubMed: 20140889 (PDB entries with the same primary citation)
DOI: 10.1002/jmr.1020
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.16350 1.0% 0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-14