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8HQ6	KL2 in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Jian, L. Deposit date: 2022-12-13 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
8HQ3	KL1 in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Jian, L. Deposit date: 2022-12-13 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
8HQ4	B27 in complex with CRM1-Ran-RanBP1 Descriptor: 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... Authors: Lei, Y, Sun, Q. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.12 Å) Cite: B27 in complex with CRM1-Ran-RanBP1 To Be Published
8HQ5	G6 in complex with CRM1-Ran-RanBP1 Descriptor: 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.25 Å) Cite: F1 in complex with CRM1-Ran-RanBP1 To Be Published
5ZPU	LFS829 in complex with CRM1-Ran-RanBP1 Descriptor: (Z)-{[(3E)-4-{(R)-[3,5-bis(trifluoromethyl)phenyl]sulfinyl}but-3-en-1-yl]imino}methanethiol, CHLORIDE ION, Exportin-1,Exportin-1, ... Authors: Sun, Q, Lei, Y. Deposit date: 2018-04-16 Release date: 2019-04-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: To be published To Be Published
2GZD	Crystal Structure of Rab11 in Complex with Rab11-FIP2 Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rab11 family-interacting protein 2, ... Authors: Khan, A.R. Deposit date: 2006-05-11 Release date: 2006-08-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Crystal structure of rab11 in complex with rab11 family interacting protein 2. Structure, 14, 2006
2F9L	3D structure of inactive human Rab11b GTPase Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAB11B, ... Authors: Scapin, S.M.N, Guimaraes, B.G, Zanchin, N.I.T. Deposit date: 2005-12-06 Release date: 2006-04-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.55 Å) Cite: The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform. J.Struct.Biol., 154, 2006
6CIT	Crystal Structure of MVM NS2 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2018-02-25 Release date: 2018-06-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.027 Å) Cite: Correlation of CRM1-NES affinity with nuclear export activity. Mol. Biol. Cell, 29, 2018
4HAW	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548A)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HB4	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(537DLTVK541/GLCEQ)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
2GZH	Crystal Structure of Rab11 in Complex with Rab11-Family Interacting Protein 2 Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Khan, A.R. Deposit date: 2006-05-11 Release date: 2006-08-15 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Crystal structure of rab11 in complex with rab11 family interacting protein 2. Structure, 14, 2006
4HAZ	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(R543S,K548E,K579Q)-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAY	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548E,K579Q)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4C4P	Crystal Structure of Wild-Type Rab11 Complexed to FIP2 Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAB11 FAMILY-INTERACTING PROTEIN 2, ... Authors: Sultana, A, Khan, A.R. Deposit date: 2013-09-07 Release date: 2013-09-18 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and Functional Analysis of Fip2 Binding to the Endosome-Localised Rab25 Gtpase Biochim.Biophys.Acta, 1834, 2013
4HB3	Crystal structure of CRM1(T539S)-Ran-RanBP1 with weakly bound unmodeled Leptomycin B Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAT	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4GPT	Crystal structure of KPT251 in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, 2-(2-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}ethyl)-1,3,4-oxadiazole, CHLORIDE ION, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-08-21 Release date: 2012-09-05 Last modified: 2013-01-23 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia, 27, 2013
4HB0	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAX	Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1(K579A)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAV	Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1 Descriptor: Anguinomycin A, bound form, CHLORIDE ION, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HB2	Crystal structure of CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAU	Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
2HV8	Crystal structure of GTP-bound Rab11 in complex with FIP3 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Eathiraj, S, Mishra, A, Prekeris, R, Lambright, D.G. Deposit date: 2006-07-27 Release date: 2006-11-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structural Basis for Rab11-mediated Recruitment of FIP3 to Recycling Endosomes. J.Mol.Biol., 364, 2006
2D9C	Solution structure of the first ig-like domain of signal-regulatory protein beta-1 (SIRP-beta-1) Descriptor: Signal-regulatory protein beta-1 Authors: Nagashima, K, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-12-09 Release date: 2006-12-09 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Solution structure of the first ig-like domain of signal-regulatory protein beta-1 ( SIRP-beta-1) To be Published
2D7C	Crystal structure of human Rab11 in complex with FIP3 Rab-binding domain Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Shiba, T, Koga, H, Shin, H.W, Kawasaki, M, Kato, R, Nakayama, K, Wakatsuki, S. Deposit date: 2005-11-16 Release date: 2006-09-26 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. Proc.Natl.Acad.Sci.Usa, 103, 2006

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