4K31
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![BU of 4k31 by Molmil](/molmil-images/mine/4k31) | Crystal structure of apramycin bound to the leishmanial rRNA A-site | Descriptor: | APRAMYCIN, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*UP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') | Authors: | Shalev, M, Kondo, J, Adir, N, Baasov, T. | Deposit date: | 2013-04-10 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.415 Å) | Cite: | Identification of the molecular attributes required for aminoglycoside activity against Leishmania. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KK9
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4KGE
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![BU of 4kge by Molmil](/molmil-images/mine/4kge) | Crystal structure of near-infrared fluorescent protein with an extended stokes shift, pH 4.5 | Descriptor: | CHLORIDE ION, TagRFP675, red fluorescent protein | Authors: | Malashkevich, V.N, Piatkevich, K, Almo, S.C, Verkhusha, V, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2013-04-29 | Release date: | 2013-05-08 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Extended Stokes shift in fluorescent proteins: chromophore-protein interactions in a near-infrared TagRFP675 variant. Sci Rep, 3, 2013
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4K3C
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![BU of 4k3c by Molmil](/molmil-images/mine/4k3c) | The crystal structure of BamA from Haemophilus ducreyi lacking POTRA domains 1-3 | Descriptor: | Outer membrane protein assembly factor BamA | Authors: | Noinaj, N, Lukacik, P, Chang, H, Easley, N, Buchanan, S.K. | Deposit date: | 2013-04-10 | Release date: | 2013-09-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.913 Å) | Cite: | Structural insight into the biogenesis of beta-barrel membrane proteins. Nature, 501, 2013
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4LCV
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![BU of 4lcv by Molmil](/molmil-images/mine/4lcv) | Crystal Structure of DOC2B C2A domain | Descriptor: | BETA-MERCAPTOETHANOL, CALCIUM ION, CITRATE ANION, ... | Authors: | Giladi, M, Almagor, L, Hirsch, J.A. | Deposit date: | 2013-06-23 | Release date: | 2013-09-11 | Last modified: | 2013-11-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The C2B Domain Is the Primary Ca(2+) Sensor in DOC2B: A Structural and Functional Analysis. J.Mol.Biol., 425, 2013
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4LIL
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![BU of 4lil by Molmil](/molmil-images/mine/4lil) | Crystal structure of the catalytic subunit of human primase bound to UTP and Mn | Descriptor: | DNA primase small subunit, MANGANESE (II) ION, URIDINE 5'-TRIPHOSPHATE, ... | Authors: | Vaithiyalingam, S, Eichman, B.F, Chazin, W.J. | Deposit date: | 2013-07-02 | Release date: | 2013-12-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase. J.Mol.Biol., 426, 2014
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4LK9
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![BU of 4lk9 by Molmil](/molmil-images/mine/4lk9) | Crystal Structure of MOZ double PHD finger histone H3 tail complex | Descriptor: | Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION | Authors: | Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. | Deposit date: | 2013-07-07 | Release date: | 2013-10-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
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4LLY
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![BU of 4lly by Molmil](/molmil-images/mine/4lly) | Crystal structure of Pertuzumab Clambda Fab with variable and constant domain redesigns (VRD2 and CRD2) at 1.6A | Descriptor: | GLYCEROL, MAGNESIUM ION, light chain Clambda, ... | Authors: | Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S. | Deposit date: | 2013-07-09 | Release date: | 2014-01-29 | Last modified: | 2019-06-26 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat.Biotechnol., 32, 2014
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4K5C
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4KMN
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![BU of 4kmn by Molmil](/molmil-images/mine/4kmn) | Structure of cIAP1-BIR3 and inhibitor | Descriptor: | (2S)-N-{(2R)-1-[(2R,4S)-2-{[6,6'-difluoro-3'-({(2R,4S)-4-hydroxy-1-[(2S)-2-{[(2S)-2-(methylamino)propanoyl]amino}butanoyl]pyrrolidin-2-yl}methyl)-1H,1'H-2,2'-biindol-3-yl]methyl}-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl}-2-(methylamino)propanamide, Baculoviral IAP repeat-containing protein 2, PHOSPHATE ION, ... | Authors: | Li, X, Wang, J, Condon, S.M, Shi, Y. | Deposit date: | 2013-05-08 | Release date: | 2014-05-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.523 Å) | Cite: | Structure of cIAP1-BIR3 and inhibitor To be Published
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4KPU
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![BU of 4kpu by Molmil](/molmil-images/mine/4kpu) | Electron transferring flavoprotein of Acidaminococcus fermentans: Towards a mechanism of flavin-based electron bifurcation | Descriptor: | CHLORIDE ION, Electron transfer flavoprotein alpha subunit, Electron transfer flavoprotein alpha/beta-subunit, ... | Authors: | Mowafy, A.M, Chowdhury, N.P, Demmer, J, Upadhyay, V, Kolzer, S, Jayamani, E, Kahnt, J, Demmer, U, Ermler, U, Buckel, W. | Deposit date: | 2013-05-14 | Release date: | 2014-01-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Studies on the Mechanism of Electron Bifurcation Catalyzed by Electron Transferring Flavoprotein (Etf) and Butyryl-CoA Dehydrogenase (Bcd) of Acidaminococcus fermentans. J.Biol.Chem., 289, 2014
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4KQT
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4KJQ
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4KK5
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4KK8
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4LOU
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4LXR
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![BU of 4lxr by Molmil](/molmil-images/mine/4lxr) | Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Stelter, M, Parthier, C, Breithaupt, C, Stubbs, M.T. | Deposit date: | 2013-07-30 | Release date: | 2014-04-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity. Proc.Natl.Acad.Sci.USA, 111, 2014
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4M1Y
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![BU of 4m1y by Molmil](/molmil-images/mine/4m1y) | Crystal Structure of small molecule vinylsulfonamide 15 covalently bound to K-Ras G12C | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[N-(5,7-dichloro-2,1,3-benzothiadiazol-4-yl)glycyl]piperidin-4-yl}ethanesulfonamide | Authors: | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | Deposit date: | 2013-08-04 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.491 Å) | Cite: | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4KKC
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4KKB
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4KHO
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4LOP
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![BU of 4lop by Molmil](/molmil-images/mine/4lop) | Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form) | Descriptor: | 1,2-ETHANEDIOL, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, L(+)-TARTARIC ACID, ... | Authors: | Chaikuad, A, DeNicola, G.F, Krojer, T, Allerston, C.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2013-07-13 | Release date: | 2013-08-21 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1. Nat.Struct.Mol.Biol., 20, 2013
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4HZ6
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![BU of 4hz6 by Molmil](/molmil-images/mine/4hz6) | crystal structure of BglB | Descriptor: | Beta-glucosidase, GLYCEROL | Authors: | Hwang, K.Y, Nam, K.H. | Deposit date: | 2012-11-14 | Release date: | 2012-12-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural insights into the substrate recognition properties of beta-glucosidase. Biochem.Biophys.Res.Commun., 391, 2010
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4I5L
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![BU of 4i5l by Molmil](/molmil-images/mine/4i5l) | Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, MALONATE ION, ... | Authors: | Wlodarchak, N, Satyshur, K.A, Guo, F, Xing, Y. | Deposit date: | 2012-11-28 | Release date: | 2013-05-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation. Cell Res., 23, 2013
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4IDI
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![BU of 4idi by Molmil](/molmil-images/mine/4idi) | Crystal Structure of Rurm1-related protein from Plasmodium Yoelii, PY06420 | Descriptor: | GLYCEROL, Oryza sativa Rurm1-related | Authors: | Wernimont, A.K, Tempel, W, Lew, J, Walker, J, Arrowsmith, C.H, Edwards, A.M, Schapira, M, Bountra, C, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) | Deposit date: | 2012-12-12 | Release date: | 2013-12-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of Rurm1-related protein from Plasmodium Yoelii, PY06420 To be Published
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