4K31

Crystal structure of apramycin bound to the leishmanial rRNA A-site

Summary for 4K31

• Entry DOI: 10.2210/pdb4k31/pdb
• Related: 4K32
• Descriptor: RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*UP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3'), APRAMYCIN (3 entities in total)
• Functional Keywords: rrna duplex, ribosomal a-site, aminoglycoside, ribosome, rna, rna-antibiotic complex, rna/antibiotic
• Biological source: Leishmania
• Total number of polymer chains: 2
• Total formula weight: 16871.09

Authors

Shalev, M.,Kondo, J.,Adir, N.,Baasov, T. (deposition date: 2013-04-10, release date: 2013-07-31, Last modification date: 2023-09-20)

• Primary citation: Shalev, M.,Kondo, J.,Kopelyanskiy, D.,Jaffe, C.L.,Adir, N.,Baasov, T.; Identification of the molecular attributes required for aminoglycoside activity against Leishmania.; Proc.Natl.Acad.Sci.USA, 110:13333-13338, 2013; PubMed: 23898171; DOI: 10.1073/pnas.1307365110

Experimental method

X-RAY DIFFRACTION (1.415 Å)