8GF8
| Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, ... | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2023-03-07 | Release date: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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8GF9
| Cryo-EM structure of human TRPV1 in cNW11 nanodisc and POPC:POPE:POPG lipids | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, ... | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2023-03-07 | Release date: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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7RQV
| Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an intermediate-closed state, class II | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | Authors: | Kwon, D.H, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-08-08 | Release date: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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8GFA
| Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791 | Descriptor: | (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2023-03-07 | Release date: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.29 Å) | Cite: | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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1FTA
| FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE, 1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, FRUCTOSE-1,6-BISPHOSPHATASE | Authors: | Zhang, Y, Liang, J.-Y, Huang, S, Lipscomb, W.N. | Deposit date: | 1993-09-27 | Release date: | 1995-11-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The allosteric site of human liver fructose-1,6-bisphosphatase. Analysis of six AMP site mutants based on the crystal structure. J.Biol.Chem., 269, 1994
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8BQW
| Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy | Descriptor: | Alpha-synuclein, Unknown protein | Authors: | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | Deposit date: | 2023-01-18 | Release date: | 2023-02-22 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145, 2023
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8BQV
| Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy | Descriptor: | Alpha-synuclein, Unknown protein | Authors: | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | Deposit date: | 2023-01-18 | Release date: | 2023-02-22 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2 Å) | Cite: | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145, 2023
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8GCR
| HPV16 E6-E6AP-p53 complex | Descriptor: | Cellular tumor antigen p53, Maltose/maltodextrin-binding periplasmic protein,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Bratkowski, M.A, Wang, J.C.K, Hao, Q, Nile, A.H. | Deposit date: | 2023-03-02 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structure of the p53 degradation complex from HPV16. Nat Commun, 15, 2024
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3QZT
| Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II | Descriptor: | GLYCEROL, Histone H4, Nucleosome-remodeling factor subunit BPTF | Authors: | Li, H, Ruthenburg, A.J, Patel, D.J. | Deposit date: | 2011-03-07 | Release date: | 2011-06-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
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8CDG
| Crystal structure of human IL-17A cytokine in complex with macrocycle | Descriptor: | (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid, Interleukin-17A | Authors: | Schulze, M.-S. | Deposit date: | 2023-01-30 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism. Chem Sci, 14, 2023
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8A4L
| Lipidic alpha-synuclein fibril - polymorph L2A | Descriptor: | Alpha-synuclein | Authors: | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | Deposit date: | 2022-06-12 | Release date: | 2022-08-17 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022
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3K44
| Crystal Structure of Drosophila melanogaster Pur-alpha | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Purine-rich binding protein-alpha, ... | Authors: | Graebsch, A, Roche, S, Niessing, D. | Deposit date: | 2009-10-05 | Release date: | 2009-10-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | X-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-acid binding surface Proc.Natl.Acad.Sci.USA, 106, 2009
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8CHW
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8CE7
| Type1 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein | Descriptor: | Alpha-synuclein | Authors: | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | Deposit date: | 2023-02-01 | Release date: | 2023-03-01 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145, 2023
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8CEB
| Type2 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein | Descriptor: | Alpha-synuclein | Authors: | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Sew, P.C, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | Deposit date: | 2023-02-01 | Release date: | 2023-03-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145, 2023
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6JXD
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4NFT
| Crystal structure of human lnkH2B-h2A.Z-Anp32e | Descriptor: | Acidic leucine-rich nuclear phosphoprotein 32 family member E, Histone H2B type 2-E, Histone H2A.Z | Authors: | Shan, S, Pan, L, Mao, Z, Wang, W, Sun, J, Dong, Q, Liang, X, Ding, X, Chen, S, Dai, L, Zhang, Z, Zhu, B, Zhou, Z. | Deposit date: | 2013-11-01 | Release date: | 2014-04-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z Cell Res., 24, 2014
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4DFY
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5YK3
| human Ragulator complex | Descriptor: | Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... | Authors: | Wu, G, Mu, Z. | Deposit date: | 2017-10-12 | Release date: | 2019-01-23 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane Cell Discov, 3, 2017
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6UIB
| Crystal structure of IL23 bound to peptide 23-652 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ... | Authors: | Durbin, J.D, Wang, J, Afshar, S. | Deposit date: | 2019-09-30 | Release date: | 2020-07-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage. Plos One, 15, 2020
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2XPN
| Crystal structure of a Spt6-Iws1(Spn1) complex from Encephalitozoon cuniculi, Form I | Descriptor: | BROMIDE ION, CHROMATIN STRUCTURE MODULATOR, IWS1 | Authors: | Diebold, M.-L, Koch, M, Cura, V, Cavarelli, J, Romier, C. | Deposit date: | 2010-08-27 | Release date: | 2010-11-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The Structure of an Iws1/Spt6 Complex Reveals an Interaction Domain Conserved in Tfiis, Elongin a and Med26 Embo J., 29, 2010
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5YK5
| structure of the human Lamtor4-Lamtor5 complex | Descriptor: | Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5 | Authors: | Wu, G, Mu, Z. | Deposit date: | 2017-10-12 | Release date: | 2018-12-12 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane Cell Discov, 3, 2017
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1TIV
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2XPP
| Crystal structure of a Spt6-Iws1(Spn1) complex from Encephalitozoon cuniculi, Form III | Descriptor: | CHROMATIN STRUCTURE MODULATOR, IWS1 | Authors: | Diebold, M.-L, Koch, M, Cura, V, Cavarelli, J, Romier, C. | Deposit date: | 2010-08-27 | Release date: | 2010-11-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | The Structure of an Iws1/Spt6 Complex Reveals an Interaction Domain Conserved in Tfiis, Elongin a and Med26 Embo J., 29, 2010
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7ZAN
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