4PBY
| Structure of the human RbAp48-MTA1(656-686) complex | Descriptor: | Histone-binding protein RBBP4, ISOPROPYL ALCOHOL, Metastasis-associated protein MTA1 | Authors: | Murthy, A, Lejon, S, Alqarni, S.S.M, Silva, A.P.G, Watson, A.A, Mackay, J.P, Laue, E.D. | Deposit date: | 2014-04-14 | Release date: | 2014-06-11 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex. J.Biol.Chem., 289, 2014
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4PC0
| Structure of the human RbAp48-MTA1(670-711) complex | Descriptor: | CALCIUM ION, GLYCEROL, Histone-binding protein RBBP4, ... | Authors: | Alqarni, S.S.M, Silva, A.P.G, Mackay, J.P, Laue, E.D. | Deposit date: | 2014-04-14 | Release date: | 2014-06-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex. J.Biol.Chem., 289, 2014
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4PSW
| Crystal structure of histone acetyltransferase complex | Descriptor: | COENZYME A, Histone H4 type VIII, Histone acetyltransferase type B catalytic subunit, ... | Authors: | Yang, M, Li, Y. | Deposit date: | 2014-03-08 | Release date: | 2014-07-09 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex Genes Dev., 28, 2014
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4R7A
| Crystal Structure of RBBP4 bound to PHF6 peptide | Descriptor: | GLYCEROL, Histone-binding protein RBBP4, PHD finger protein 6 | Authors: | Liu, Z, Li, F, Zhang, B, Li, S, Wu, J, Shi, Y. | Deposit date: | 2014-08-27 | Release date: | 2015-01-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by the Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex J.Biol.Chem., 290, 2015
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2OVQ
| Structure of the Skp1-Fbw7-CyclinEdegC complex | Descriptor: | F-box/WD repeat protein 7, S-phase kinase-associated protein 1A, SULFATE ION, ... | Authors: | Hao, B, Oehlmann, S, Sowa, M.E, Harper, J.W, Pavletich, N.P. | Deposit date: | 2007-02-14 | Release date: | 2007-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases Mol.Cell, 26, 2007
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2OVP
| Structure of the Skp1-Fbw7 complex | Descriptor: | F-box/WD repeat protein 7, S-phase kinase-associated protein 1A | Authors: | Hao, B, Oehlmann, S, Sowa, M.E, Harper, J.W, Pavletich, N.P. | Deposit date: | 2007-02-14 | Release date: | 2007-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases Mol.Cell, 26, 2007
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2PBI
| The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure | Descriptor: | GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9 | Authors: | Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J. | Deposit date: | 2007-03-28 | Release date: | 2008-01-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat.Struct.Mol.Biol., 15, 2008
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2OVR
| Structure of the Skp1-Fbw7-CyclinEdegN complex | Descriptor: | F-box/WD repeat protein 7, S-phase kinase-associated protein 1A, SULFATE ION, ... | Authors: | Hao, B, Oehlmann, S, Sowa, M.E, Harper, J.W, Pavletich, N.P. | Deposit date: | 2007-02-14 | Release date: | 2007-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases Mol.Cell, 26, 2007
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2PM7
| Crystal structure of yeast Sec13/31 edge element of the COPII vesicular coat, selenomethionine version | Descriptor: | Protein transport protein SEC13, Protein transport protein SEC31 | Authors: | Goldberg, J, Fath, S, Mancias, J.D, Bi, X. | Deposit date: | 2007-04-20 | Release date: | 2007-07-03 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure and Organization of Coat Proteins in the COPII Cage. Cell(Cambridge,Mass.), 129, 2007
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2PM6
| Crystal Structure of yeast Sec13/31 edge element of the COPII vesicular coat, native version | Descriptor: | Protein transport protein SEC13, Protein transport protein SEC31 | Authors: | Goldberg, J, Fath, S, Mancias, J.D, Bi, X. | Deposit date: | 2007-04-20 | Release date: | 2007-07-03 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structure and Organization of Coat Proteins in the COPII Cage. Cell(Cambridge,Mass.), 129, 2007
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2QXV
| Structural basis of EZH2 recognition by EED | Descriptor: | Embryonic ectoderm development, Enhancer of zeste homolog 2 | Authors: | Han, Z. | Deposit date: | 2007-08-13 | Release date: | 2007-08-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structural basis of EZH2 recognition by EED Structure, 15, 2007
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2TRC
| PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX | Descriptor: | GADOLINIUM ATOM, PHOSDUCIN, TRANSDUCIN | Authors: | Gaudet, R, Bohm, A, Sigler, P.B. | Deposit date: | 1997-01-06 | Release date: | 1997-06-05 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell(Cambridge,Mass.), 87, 1996
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3MZL
| Sec13/Sec31 edge element, loop deletion mutant | Descriptor: | Protein transport protein SEC13, Protein transport protein SEC31 | Authors: | Whittle, J.R, Schwartz, T.U. | Deposit date: | 2010-05-12 | Release date: | 2010-08-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat. J.Cell Biol., 190, 2010
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4W2R
| Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | Descriptor: | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of zeste 2 polycomb repressive complex 2 subunit, Polycomb protein EED, ... | Authors: | Gajiwala, K.S, Brooun, A, Liu, W, Deng, Y, Stewart, A.E. | Deposit date: | 2017-09-25 | Release date: | 2017-12-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J. Med. Chem., 61, 2018
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4WJV
| Crystal structure of Rsa4 in complex with the Nsa2 binding peptide | Descriptor: | Maltose-binding periplasmic protein, Ribosome assembly protein 4, Ribosome biogenesis protein NSA2, ... | Authors: | Holdermann, I, Paternoga, H, Bassler, J, Hurt, E, Sinning, I. | Deposit date: | 2014-10-01 | Release date: | 2014-11-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J.Cell Biol., 207, 2014
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4WJU
| Crystal structure of Rsa4 from Saccharomyces cerevisiae | Descriptor: | GLYCEROL, Ribosome assembly protein 4 | Authors: | Holdermann, I, Bassler, J, Hurt, E, Sinning, I. | Deposit date: | 2014-10-01 | Release date: | 2014-11-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J.Cell Biol., 207, 2014
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4X63
| Crystal structure of PRMT5:MEP50 with EPZ015666 and SAH | Descriptor: | Methylosome protein 50, N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide, Protein arginine N-methyltransferase 5, ... | Authors: | Boriack-Sjodin, P.A. | Deposit date: | 2014-12-06 | Release date: | 2015-04-22 | Last modified: | 2015-05-27 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 11, 2015
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4X60
| Crystal structure of PRMT5:MEP50 with EPZ015666 and sinefungin | Descriptor: | GLYCEROL, Methylosome protein 50, N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide, ... | Authors: | Boriack-Sjodin, P.A. | Deposit date: | 2014-12-06 | Release date: | 2015-04-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 11, 2015
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4X61
| Crystal structure of PRMT5:MEP50 with EPZ015666 and SAM | Descriptor: | GLYCEROL, Methylosome protein 50, N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide, ... | Authors: | Boriack-Sjodin, P.A. | Deposit date: | 2014-12-06 | Release date: | 2015-04-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 11, 2015
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4XMN
| Structure of the yeast coat nucleoporin complex, space group P212121 | Descriptor: | Antibody 87 heavy chain, Antibody 87 light chain, Nucleoporin NUP120, ... | Authors: | Stuwe, T, Correia, A.R, Lin, D.H, Paduch, M, Lu, V.T, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2015-01-14 | Release date: | 2015-03-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (7.6 Å) | Cite: | Nuclear pores. Architecture of the nuclear pore complex coat. Science, 347, 2015
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4XMM
| Structure of the yeast coat nucleoporin complex, space group C2 | Descriptor: | Antibody 57 heavy chain, Antibody 57 light chain, Nucleoporin NUP120, ... | Authors: | Stuwe, T, Correia, A.R, Lin, D.H, Paduch, M, Lu, V.T, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2015-01-14 | Release date: | 2015-03-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (7.384 Å) | Cite: | Nuclear pores. Architecture of the nuclear pore complex coat. Science, 347, 2015
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3SFZ
| Crystal structure of full-length murine Apaf-1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Apoptotic peptidase activating factor 1, GAMMA-BUTYROLACTONE | Authors: | Eschenburg, S, Reubold, T.F. | Deposit date: | 2011-06-14 | Release date: | 2011-08-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis. Structure, 19, 2011
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3SHF
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3C99
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3C9C
| Structural Basis of Histone H4 Recognition by p55 | Descriptor: | CADMIUM ION, Chromatin assembly factor 1 p55 subunit, Histone H4, ... | Authors: | Song, J.J, Garlick, J.D, Kingston, R.E. | Deposit date: | 2008-02-15 | Release date: | 2008-05-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of histone H4 recognition by p55. Genes Dev., 22, 2008
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