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2PZA
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BU of 2pza by Molmil
NAD+ Synthetase from Bacillus anthracis with AMP + PPi and Mg2+
Descriptor: ADENOSINE MONOPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:McDonald, H.M, Pruett, P.S, Deivanayagam, C, Protasevich, I.I, Carson, W.M, DeLucas, L.J, Brouillette, W.J, Brouillette, C.G.
Deposit date:2007-05-17
Release date:2007-07-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD(+) synthetase from Bacillus anthracis.
Acta Crystallogr.,Sect.D, 63, 2007
5X0K
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BU of 5x0k by Molmil
Free serine kinase (E30Q mutant) in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Free serine kinase
Authors:Nagata, R, Fujihashi, M, Miki, K.
Deposit date:2017-01-20
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Study on the Reaction Mechanism of a Free Serine Kinase Involved in Cysteine Biosynthesis
ACS Chem. Biol., 12, 2017
5X0B
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BU of 5x0b by Molmil
Free serine kinase in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Free serine kinase
Authors:Nagata, R, Fujihashi, M, Miki, K.
Deposit date:2017-01-20
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Study on the Reaction Mechanism of a Free Serine Kinase Involved in Cysteine Biosynthesis
ACS Chem. Biol., 12, 2017
5X0E
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BU of 5x0e by Molmil
Free serine kinase (E30A mutant) in complex with phosphoserine and AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Free serine kinase, MAGNESIUM ION, ...
Authors:Nagata, R, Fujihashi, M, Miki, K.
Deposit date:2017-01-20
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Study on the Reaction Mechanism of a Free Serine Kinase Involved in Cysteine Biosynthesis
ACS Chem. Biol., 12, 2017
2MNG
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BU of 2mng by Molmil
Apo Structure of human HCN4 CNBD solved by NMR
Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Akimoto, M, Zhang, Z, Boulton, S, Selvaratnam, R, VanSchouwen, B, Gloyd, M, Accili, E.A, Lange, O.F, Melacini, G.
Deposit date:2014-04-03
Release date:2014-06-04
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.
J.Biol.Chem., 289, 2014
6EP5
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BU of 6ep5 by Molmil
Enterococcus faecalis FIC protein in complex with ADP.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Fic family protein
Authors:Veyron, S, Cherfils, J.
Deposit date:2017-10-10
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.928 Å)
Cite:A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins.
Nat Commun, 10, 2019
6EP2
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BU of 6ep2 by Molmil
Enterococcus faecalis FIC protein in complex with ADP and calcium ion.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Fic family protein
Authors:Veyron, S, Cherfils, J.
Deposit date:2017-10-10
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins.
Nat Commun, 10, 2019
6ER8
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BU of 6er8 by Molmil
Enterococcus faecalis FIC protein in complex with phosphate.
Descriptor: ACETATE ION, Fic family protein, PHOSPHATE ION
Authors:Veyron, S, Cherfils, J.
Deposit date:2017-10-17
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins.
Nat Commun, 10, 2019
4INI
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BU of 4ini by Molmil
Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP
Descriptor: 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Maize, K.M, Wagner, C.R, Finzel, B.C.
Deposit date:2013-01-04
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.
Febs J., 280, 2013
3LUD
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BU of 3lud by Molmil
Crystal structure of MID domain from hAGO2 in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Protein argonaute-2
Authors:Frank, F, Sonenberg, N, Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
6ZZA
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BU of 6zza by Molmil
Crystal structure of CbpB in complex with c-di-AMP
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CBS domain-containing protein, SULFATE ION
Authors:Mechaly, A.E, Covaleda-Cortes, G, Kaminski, P.A.
Deposit date:2020-08-04
Release date:2021-08-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.491 Å)
Cite:Crystal structure of CbpB in complex with c-di-AMP
To Be Published
6NT5
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BU of 6nt5 by Molmil
Cryo-EM structure of full-length human STING in the apo state
Descriptor: Stimulator of interferon protein
Authors:Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 567, 2019
8IY2
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BU of 8iy2 by Molmil
Structure of Acb2 complexed with 3',3'-cGAMP and cAAA
Descriptor: 1,2-ETHANEDIOL, GUANOSINE-3'-MONOPHOSPHATE, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, ...
Authors:Cao, X.L, Xiao, Y, Feng, Y.
Deposit date:2023-04-03
Release date:2024-02-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.
Mol.Cell, 84, 2024
3IM4
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BU of 3im4 by Molmil
Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2
Descriptor: Dual specificity A kinase-anchoring protein 2, ZINC ION, cAMP-dependent protein kinase type I-alpha regulatory subunit
Authors:Sarma, G.N, Kinderman, F.S, Kim, C, von Daake, S, Taylor, S.S.
Deposit date:2009-08-09
Release date:2010-02-02
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity
Structure, 18, 2010
6NT6
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BU of 6nt6 by Molmil
Cryo-EM structure of full-length chicken STING in the apo state
Descriptor: Stimulator of interferon genes protein
Authors:Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 567, 2019
2RIH
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BU of 2rih by Molmil
CBS domain protein PAE2072 from Pyrobaculum aerophilum
Descriptor: ACETIC ACID, Conserved protein with 2 CBS domains, SULFATE ION
Authors:Lee, T.M, King, N.P, Sawaya, M.R, Cascio, D, Yeates, T.O.
Deposit date:2007-10-10
Release date:2008-06-17
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures and Functional Implications of an AMP-Binding Cystathionine beta-Synthase Domain Protein from a Hyperthermophilic Archaeon
J.Mol.Biol., 380, 2008
6CJU
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BU of 6cju by Molmil
Structure of the SthK cyclic nucleotide-gated potassium channel in complex with cAMP
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK cyclic nucleotide-gated potassium channel
Authors:Nimigean, C.M, Rheinberger, J.
Deposit date:2018-02-26
Release date:2018-08-01
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.
Elife, 7, 2018
3X2U
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BU of 3x2u by Molmil
Michaelis-like initial complex of cAMP-dependent Protein Kinase Catalytic Subunit.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Substrate Peptide, ...
Authors:Das, A, Langan, P, Gerlits, O, Kovalevsky, A.Y, Heller, W.T.
Deposit date:2015-01-02
Release date:2015-12-16
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation.
Structure, 23, 2015
2PTQ
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BU of 2ptq by Molmil
Crystal structure of Escherichia coli adenylosuccinate lyase mutant H171N with bound AMP and fumarate
Descriptor: ADENOSINE MONOPHOSPHATE, Adenylosuccinate lyase, FUMARIC ACID
Authors:Tsai, M, Howell, P.L.
Deposit date:2007-05-08
Release date:2007-07-03
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Substrate and Product Complexes of Escherichia coli Adenylosuccinate Lyase Provide New Insights into the Enzymatic Mechanism.
J.Mol.Biol., 370, 2007
8OFO
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BU of 8ofo by Molmil
Structure of Enterococcus faecium CdaA
Descriptor: 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Diadenylate cyclase
Authors:Garbers, T.B, Neumann, P, Ficner, R.
Deposit date:2023-03-16
Release date:2023-06-21
Last modified:2025-05-14
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystallographic fragment screen of the c-di-AMP-synthesizing enzyme CdaA from Bacillus subtilis.
Acta Crystallogr.,Sect.F, 80, 2024
7AUR
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BU of 7aur by Molmil
Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with AMP-PNP
Descriptor: CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase DDP1, MAGNESIUM ION, ...
Authors:Marquez-Monino, M.A, Gonzalez, B.
Deposit date:2020-11-03
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Multiple substrate recognition by yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase through phosphate clamping.
Sci Adv, 7, 2021
1ZN8
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BU of 1zn8 by Molmil
Human Adenine Phosphoribosyltransferase Complexed with AMP, in Space Group P1 at 1.76 A Resolution
Descriptor: ADENOSINE MONOPHOSPHATE, Adenine phosphoribosyltransferase, CHLORIDE ION
Authors:Iulek, J, Silva, M, Tomich, C.H.T.P, Thiemann, O.H.
Deposit date:2005-05-11
Release date:2006-04-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Complexes of Human Adenine Phosphoribosyltransferase Reveal Novel Features of the APRT Catalytic Mechanism
J.Biomol.Struct.Dyn., 25, 2008
8OFH
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BU of 8ofh by Molmil
Streptococcus pneumoniae CdaA
Descriptor: Diadenylate cyclase
Authors:Garbers, T.B, Neumann, P, Ficner, R.
Deposit date:2023-03-15
Release date:2023-06-21
Last modified:2025-05-14
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystallographic fragment screen of the c-di-AMP-synthesizing enzyme CdaA from Bacillus subtilis.
Acta Crystallogr.,Sect.F, 80, 2024
2BZK
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BU of 2bzk by Molmil
CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AMPPNP AND PIMTIDE
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PIMTIDE, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1
Authors:Debreczeni, J.E, Bullock, A, Knapp, S, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A.
Deposit date:2005-08-18
Release date:2005-11-03
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of the Human Pim1 in Complex with Amppnp and Pimtide
To be Published
6ESA
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BU of 6esa by Molmil
Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and AMP
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, beta-D-ribopyranose, ...
Authors:Mueller, J.M, Heine, A, Klebe, G.
Deposit date:2017-10-19
Release date:2018-10-31
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.307 Å)
Cite:Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage
Acs Omega, 2019

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