9B5K
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3L1Z
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6ZHU
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![BU of 6zhu by Molmil](/molmil-images/mine/6zhu) | Yeast Uba1 in complex with Ubc3 and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ubiquitin-activating enzyme E1 1, ... | Authors: | Misra, M, Schindelin, H. | Deposit date: | 2020-06-23 | Release date: | 2022-01-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | ATP induced conformational changes facilitate E1-E2 disulfide bridging in the ubiquitin system To Be Published
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9B5O
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6W9D
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8SE9
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![BU of 8se9 by Molmil](/molmil-images/mine/8se9) | Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 2) | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | Authors: | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | Deposit date: | 2023-04-08 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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8SMX
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![BU of 8smx by Molmil](/molmil-images/mine/8smx) | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 2) | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-04-26 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SMY
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![BU of 8smy by Molmil](/molmil-images/mine/8smy) | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 3) | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-04-26 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SMZ
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![BU of 8smz by Molmil](/molmil-images/mine/8smz) | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (Class 4) | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-04-26 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN0
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![BU of 8sn0 by Molmil](/molmil-images/mine/8sn0) | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 5) | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-04-26 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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5ZBU
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8BTL
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![BU of 8btl by Molmil](/molmil-images/mine/8btl) | Crystal structure of a complex between the E2 conjugating enzyme UBE2A and the E3 ligase module from UBR4 | Descriptor: | Ubiquitin conjugating enzyme E2 A, ZINC ION, cDNA FLJ12511 fis, ... | Authors: | Virdee, S, Mabbitt, P.D, Barnsby-Greer, L. | Deposit date: | 2022-11-29 | Release date: | 2023-12-13 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4. Nat.Struct.Mol.Biol., 31, 2024
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8UPF
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![BU of 8upf by Molmil](/molmil-images/mine/8upf) | Cryo-EM structure of the human nucleosome core particle in complex with RNF168-UbcH5c | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-10-22 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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7W75
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8E2K
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![BU of 8e2k by Molmil](/molmil-images/mine/8e2k) | Cryo-EM structure of BIRC6/HtrA2-S306A | Descriptor: | Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial | Authors: | Hunkeler, M, Fischer, E.S. | Deposit date: | 2022-08-15 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Science, 379, 2023
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9B55
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4BWF
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![BU of 4bwf by Molmil](/molmil-images/mine/4bwf) | Pex4p-Pex22p disulphide bond mutant | Descriptor: | 1,2-ETHANEDIOL, PEROXISOME ASSEMBLY PROTEIN 22, UBIQUITIN-CONJUGATING ENZYME E2-21 KDA | Authors: | Williams, C, van den Berg, M, Stanley, W.A, Wilmanns, M, Distel, B. | Deposit date: | 2013-07-01 | Release date: | 2013-07-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | A Disulphide Bond in the E2 Enzyme Pex4P Modulates Ubiquitin-Conjugating Activity Sci.Rep., 3, 2013
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8SEB
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![BU of 8seb by Molmil](/molmil-images/mine/8seb) | Cryo-EM structure of a single loaded human UBA7-UBE2L6-ISG15 adenylate complex | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | Authors: | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | Deposit date: | 2023-04-08 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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5UDH
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![BU of 5udh by Molmil](/molmil-images/mine/5udh) | HHARI/ARIH1-UBCH7~Ubiquitin | Descriptor: | E3 ubiquitin-protein ligase ARIH1, Ubiquitin C variant, Ubiquitin-conjugating enzyme E2 L3, ... | Authors: | Miller, D.J, Schulman, B.A. | Deposit date: | 2016-12-27 | Release date: | 2017-06-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | Structural Studies of HHARI/UbcH7Ub Reveal Unique E2Ub Conformational Restriction by RBR RING1. Structure, 25, 2017
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2Y9P
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![BU of 2y9p by Molmil](/molmil-images/mine/2y9p) | Pex4p-Pex22p mutant II structure | Descriptor: | PEROXISOME ASSEMBLY PROTEIN 22, UBIQUITIN-CONJUGATING ENZYME E2-21 KDA | Authors: | Williams, C, van den Berg, M, Panjikar, S, Distel, B, Wilmanns, M. | Deposit date: | 2011-02-16 | Release date: | 2012-02-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Pex4P-Pex22P Structure To be Published
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3SY2
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7YW1
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![BU of 7yw1 by Molmil](/molmil-images/mine/7yw1) | crystal structure of UBE2O | Descriptor: | (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O | Authors: | Fu, Z, Zhu, W, Huang, H. | Deposit date: | 2022-08-20 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.27 Å) | Cite: | crystal structure of UBE2O To Be Published
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7LYB
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![BU of 7lyb by Molmil](/molmil-images/mine/7lyb) | Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c | Descriptor: | BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. | Deposit date: | 2021-03-06 | Release date: | 2021-07-28 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature, 596, 2021
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4R8P
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![BU of 4r8p by Molmil](/molmil-images/mine/4r8p) | Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle | Descriptor: | DNA (147-mer), E3 ubiquitin-protein ligase RING2, Ubiquitin-conjugating enzyme E2 D3, ... | Authors: | McGinty, R.K, Henrici, R.C, Tan, S. | Deposit date: | 2014-09-02 | Release date: | 2014-11-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2846 Å) | Cite: | Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. Nature, 514, 2014
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4DDG
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![BU of 4ddg by Molmil](/molmil-images/mine/4ddg) | Crystal structure of human OTUB1/UbcH5b~Ub/Ub | Descriptor: | Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1 | Authors: | Juang, Y.C, Sanches, M, Sicheri, F. | Deposit date: | 2012-01-18 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2987 Å) | Cite: | OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function. Mol.Cell, 45, 2012
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