4NN5
| Cytokine receptor complex - Crystal form 1A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Cytokine receptor-like factor 2, ... | Authors: | Verstraete, K, van Schie, L, Savvides, S.N. | Deposit date: | 2013-11-16 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat.Struct.Mol.Biol., 21, 2014
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4NN6
| Cytokine receptor complex - Crystal form 1B | Descriptor: | Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, Thymic stromal lymphopoietin | Authors: | Verstraete, K, van Schie, L, Savvides, S.N. | Deposit date: | 2013-11-16 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.545 Å) | Cite: | Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat.Struct.Mol.Biol., 21, 2014
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4NN7
| Cytokine receptor complex - Crystal form 2 | Descriptor: | Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, Thymic stromal lymphopoietin | Authors: | Verstraete, K, van Schie, L, Savvides, S.N. | Deposit date: | 2013-11-16 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.775 Å) | Cite: | Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat.Struct.Mol.Biol., 21, 2014
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5N47
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7XGD
| Cryo-EM structure of Apo-IGF1R map 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor 1 receptor | Authors: | Zhang, X, Wu, C. | Deposit date: | 2022-04-04 | Release date: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structure of Apo-IGF1R To Be Published
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7XLC
| conformation II of apo-IGF1R states | Descriptor: | Insulin-like growth factor 1 receptor | Authors: | Xi, Z, Cang, W. | Deposit date: | 2022-04-21 | Release date: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | conformation II of apo-IGF1R states To Be Published
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5N48
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6P67
| Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-IL-7R 2B8 Fab heavy chain, ... | Authors: | Walsh, S.T.R, Kashi, L, Kohnhorst, C.L. | Deposit date: | 2019-06-03 | Release date: | 2019-09-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models. Leukemia, 34, 2020
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6P50
| Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-7 receptor subunit alpha, anti-IL-7R 4A10 Fab heavy chain, ... | Authors: | Walsh, S.T.R, Kashi, L, Kohnhorst, C.L. | Deposit date: | 2019-05-29 | Release date: | 2019-09-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models. Leukemia, 34, 2020
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7SL7
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7SL1
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7SL4
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7SL3
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7SL2
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7SL6
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8QY5
| Structure of interleukin 6. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... | Authors: | Gardner, S, Bubeck, D, Jin, Y. | Deposit date: | 2023-10-25 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of interleukin 6. To Be Published
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8QY6
| Structure of interleukin 6 (gp130 P496L mutant). | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... | Authors: | Gardner, S, Bubeck, D, Jin, Y. | Deposit date: | 2023-10-25 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structure of interleukin 6 (gp130 P496L mutant). To Be Published
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7S8V
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7S0Q
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4K0V
| Structural basis for angiopoietin-1 mediated signaling initiation | Descriptor: | Angiopoietin-1, TEK tyrosine kinase variant | Authors: | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | Deposit date: | 2013-04-04 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4.51 Å) | Cite: | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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6POL
| Crystal structure of the human NELL1 EGF1-3-Robo3 FN1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Wang, J, Pak, J.S, Ozkan, E. | Deposit date: | 2019-07-04 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance. Nat Commun, 11, 2020
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8TAN
| CryoEM structure of MFRV-VILP bound to IGF1Rzip | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor, ... | Authors: | Kirk, N.S. | Deposit date: | 2023-06-27 | Release date: | 2024-01-17 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression. Mol Metab, 80, 2024
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6POG
| Crystal structure of the NELL2 EGF1-6-Robo3 FN1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Wang, J, Pak, J.S, Ozkan, E. | Deposit date: | 2019-07-03 | Release date: | 2020-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.755 Å) | Cite: | NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance. Nat Commun, 11, 2020
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6PXV
| Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region. | Descriptor: | Insulin, Insulin receptor | Authors: | Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. | Deposit date: | 2019-07-27 | Release date: | 2019-09-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
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6PYH
| Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved. | Descriptor: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | Authors: | Li, J, Choi, E, Yu, H.T, Bai, X.C. | Deposit date: | 2019-07-29 | Release date: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis of the activation of type 1 insulin-like growth factor receptor. Nat Commun, 10, 2019
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