PDB: 2435 resultsInfo pagesStatus searchChemie searchBIRD

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6UHY	WDR5 in complex with Myc site fragment inhibitor Descriptor: 1-cyclohexyl-1H-benzimidazole-5-carboxylic acid, WDR5 Authors: Wang, F, Fesik, S.W. Deposit date: 2019-09-29 Release date: 2020-04-15 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UHZ	WDR5 in complex with Myc site fragment inhibitor Descriptor: 1-cyclohexyl-1H-benzotriazole-5-carboxylic acid, WDR5 Authors: Wang, F, Fesik, S.w. Deposit date: 2019-09-29 Release date: 2020-04-15 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.258 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6PG7	WDR5delta32 bound to (2-(3-methoxy-3-phenylpropyl)-1H-imidazol-4-yl)methanol Descriptor: DI(HYDROXYETHYL)ETHER, WD repeat-containing protein 5, {2-[(3S)-3-methoxy-3-phenylpropyl]-1H-imidazol-4-yl}methanol Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGD	WDR5delta32 bound to peptidomimetic Descriptor: N-acetyl-L-alanyl-5-[5-(hydroxymethyl)-1H-imidazol-2-yl]-L-norvalyl-L-valinamide, SULFATE ION, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGC	WDR5delta32 bound to methyl benzyl(4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate Descriptor: SULFATE ION, WD repeat-containing protein 5, methyl benzyl{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG6	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acetamide Descriptor: CHLORIDE ION, N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}acetamide, SULFATE ION, ... Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PBG	Crystal structure of WD-repeat domain of human coatomer subunit Alpha (COPA) Descriptor: Coatomer subunit alpha, L(+)-TARTARIC ACID, UNKNOWN ATOM OR ION Authors: Halabelian, L, Zeng, H, Dong, A, Loppnau, P, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) Deposit date: 2019-06-13 Release date: 2019-06-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Crystal structure of W repeat domain of human coatomer subunit Alpha (COPA) to be published
6PG3	WDR5delta23 bound to (2-butyl-1H-imidazol-4-yl)methanol Descriptor: (2-butyl-1H-imidazol-4-yl)methanol, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGF	WDR5delta32 bound to N-(4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acrylamide Descriptor: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}prop-2-enamide, SULFATE ION, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG8	WDR5delta23 bound to (2-(3-phenylpropyl)-1H-imidazol-4-yl)methanol Descriptor: CHLORIDE ION, SULFATE ION, WD repeat-containing protein 5, ... Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG5	WDR5delta32 bound to benzyl (4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate Descriptor: SULFATE ION, WD repeat-containing protein 5, benzyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGB	WDR5delta32 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)-2-phenylacetamide Descriptor: N-{4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}-2-phenylacetamide, SULFATE ION, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG4	WDR5delta32 bound to (2-methyl-1H-imidazol-4-yl)methanol Descriptor: (2-methyl-1H-imidazol-4-yl)methanol, SULFATE ION, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG9	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)benzamide Descriptor: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}benzamide, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGA	WDR5delta32 bound to methyl (4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate Descriptor: SULFATE ION, WD repeat-containing protein 5, methyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6UOZ	Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction Descriptor: 5-bromo-3-chloro-N-[1-cyclopentyl-2-(methylsulfonyl)-1H-imidazol-4-yl]-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5 Authors: Zhao, B. Deposit date: 2019-10-16 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.532 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6V3X	Crystal structure of EED in complex with PALI1-K1241me3 peptide Descriptor: PALI1 peptide, Polycomb protein EED Authors: Zhang, Q, Davidovich, C. Deposit date: 2019-11-26 Release date: 2021-05-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.7 Å) Cite: PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis. Nat Commun, 12, 2021
6V3Y	Crystal structure of EED in complex with PALI1-K1219me3 peptide Descriptor: PALI1 peptide, Polycomb protein EED Authors: Zhang, Q, Davidovich, C. Deposit date: 2019-11-26 Release date: 2021-05-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.63 Å) Cite: PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis. Nat Commun, 12, 2021
6OI3	Crystal structure of human WDR5 in complex with monomethyl H3R2 peptide Descriptor: GLYCEROL, Monomethyl H3R2 peptide, SULFATE ION, ... Authors: Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. Deposit date: 2019-04-08 Release date: 2020-04-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.66 Å) Cite: A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
6OFZ	Crystal structure of human WDR5 Descriptor: WD repeat-containing protein 5 Authors: Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. Deposit date: 2019-04-01 Release date: 2020-04-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.85 Å) Cite: A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
6OI1	Crystal structure of human WDR5 in complex with monomethyl L-arginine Descriptor: (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, GLYCEROL, SULFATE ION, ... Authors: Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. Deposit date: 2019-04-08 Release date: 2020-04-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.68 Å) Cite: A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
6OI2	Crystal structure of human WDR5 in complex with symmetric dimethyl-L-arginine Descriptor: GLYCEROL, N3, N4-DIMETHYLARGININE, ... Authors: Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. Deposit date: 2019-04-08 Release date: 2020-04-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.68 Å) Cite: A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
6W7G	Structure of EED bound to inhibitor 1056 Descriptor: 8-(2,6-dimethylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine, FORMIC ACID, Polycomb protein EED, ... Authors: Petrunak, E.M, Stuckey, J.A. Deposit date: 2020-03-19 Release date: 2020-07-08 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.85 Å) Cite: EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development. J.Med.Chem., 63, 2020
6W7F	Structure of EED bound to inhibitor 5285 Descriptor: 8-(6-cyclopropylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine, GLYCEROL, Polycomb protein EED Authors: Petrunak, E.M, Stuckey, J.A. Deposit date: 2020-03-19 Release date: 2020-07-08 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development. J.Med.Chem., 63, 2020
6QTS	Crystal structure of a mutant Arabidopsis WD40 domain in complex with a photoreceptor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.11 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019

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